Plasma cAMP in Normal and Abnormal Human Pregnancy

Göser, R.; Jaschonek, K.; Kindler, Dean D.; Keller, Elizabeth A.; Schindler, A. E.

doi:10.1159/000299847

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Plasma cAMP levels slightly decreased at the onset of labor in these 3 labor groups. The present finding is consistent with the results of Goser et al [18] who measured plasma cAMP during PGF2a infusion for in itiation of labor in 3 patients and reported a decrease of plasma cAMP 1 h after the be ginning of the infusion of PGF2«. They stated that it was obvious from their results that plasma cAMP levels reflected the endo crine state at various stages of labor.…”

Section: Discussionsupporting

confidence: 93%

“…Weiss et al [20] mea sured high amniotic fluid cAMP in PGF2"-induced midtrimester abortion, assuming a correlation of cAMP level and fetal distress. The observation of Goser et al [18] sup ported this assumption.…”

Section: Discussionmentioning

confidence: 93%

“…The mean ± SEM were reported as 15.89 ± 0.57 pg/ml in 21-42 weeks of preg nancy [23], 38.8 ± 1.7 pg/ml in term preg nancy [24], and 22.5 ± 2.4 pmol/ml in 33-36 weeks of pregnancy [18], Although there was no significant correlation between the changing patterns of plasma concentrations of cAMP and cGMP, cGMP concentrations were also generally high in the stage of crowning of the fetal head, which may ex plain some intervention of cGMP in various hormonal activities in mother and fetus at that time.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F2α and Prostaglandin E2

Nagata

Furuya²,

Imaizumi³

et al. 1988

Gynecol Obstet Invest

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To investigate the response of cyclic nucleotides to the oxytocic agents administered for induction of labor, plasma concentrations of cyclic AMP (cAMP) and cyclic GMP (cGMP) were determined by radioimmunoassay during spontaneous labor and labor induced by oxytocin (OT), prostaglandin F_2Α (PGF_2Α), or PGE₂ (PGE₂). Subjects were 7 Japanese women in each labor group. Plasma cAMP levels significantly rose at the time of crowning of the fetal head in all 4 groups. They did not increase until that time in the 3 labor groups (spontaneous, OT-induced, and PGF_2Α-induced labor groups). In the PGE₂-induced labor group, plasma cAMP levels were significantly higher at labor onset (mean ± SEM =16.5 ± 1.3 pg/ml) when compared to the pretreatment values (13.7 ± 1.0 pg/ml), and increased thereafter gradually toward the time of crowning of the head (26.3 ± 2.0 pg/ml). Plasma cGMP levels in the OT-induced group significantly rose after the onset of labor and remained at a high level until expulsion of the fetus. Plasma cGMP levels in the other groups did not change significantly throughout labor. These results suggest that cAMP may be involved in the labor process induced by PGE₂, and that cGMP may be in that induced by OT.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F2α and Prostaglandin E2

Nagata

Furuya²,

Imaizumi³

et al. 1988

Gynecol Obstet Invest

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“…These experimental results indicate that maintenance of endometrial cAMP may be a requirement for maintenance of pregnancy. Patients that suffer from recurrent miscarriage exhibit reduced plasma and endometrial concentrations of cAMP [176-178]. Patients with this pregnancy phenotype also exhibit reduced plasma steroid hormone levels and reduced serum levels of hCG [179].…”

Section: Exogenous Relaxin Administration In a Non-human Primate Modementioning

confidence: 99%

Biology of primate relaxin: A paracrine signal in early pregnancy?

Hayes

2004

Reprod Biol Endocrinol

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Relaxin is a peptide hormone that exerts numerous effects in a variety of tissues across a broad range of species. Although first identified more than 75 years ago interest in relaxin biology has waxed and waned over the years consistent with peaks and troughs of new experimental data on its wide-ranging biological effects and advances in relaxin enabling technologies. Recent insights into species-dependent differences in relaxin biology during pregnancy have once again stimulated a relative surge of interest in the study of relaxin's reproductive biology. Identification and pharmacological characterization of orphaned relaxin receptors and exploration of its paracrine effects on pregnancy using genomic and proteomic technologies have succeeded in fueling current interest in relaxin research. Primates and non-primate vertebrates exhibit very disparate profiles of relaxin genomics, proteomics and functional biology. Non-human primates appear to exhibit a very close similarity to humans with respect to relaxin reproductive biology but the similarities and subtle differences are only just beginning to be understood. We, and others, have shown that relaxin produces significant changes to the non-human primate endometrium during the peri-implantation period that are consistent with relaxin's long perceived role as a paracrine modulator of pregnancy. The purpose of this review is to summarize the reproductive biology of relaxin in non-human primates with a specific emphasis on the paracrine role of ovarian and endometrial relaxin during embryo implantation and early pregnancy.

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Gap Junction Regulation of Vascular Tone: Implications of Modulatory Intercellular Communication During Gestation

Ampey

Morschauser

Lampe

et al. 2014

Advances in Experimental Medicine and Biology

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In the vasculature, gap junctions (GJ) play a multifaceted role by serving as direct conduits for cell–cell intercellular communication via the facilitated diffusion of signaling molecules. GJs are essential for the control of gene expression and coordinated vascular development in addition to vascular function. The coupling of endothelial cells to each other, as well as with vascular smooth muscle cells via GJs, plays a relevant role in the control of vasomotor tone, tissue perfusion and arterial blood pressure. The regulation of cell-signaling is paramount to cardiovascular adaptations of pregnancy. Pregnancy requires highly developed cell-to-cell coupling, which is affected partly through the formation of intercellular GJs by Cx43, a gap junction protein, within adjacent cell membranes to help facilitate the increase of uterine blood flow (UBF) in order to ensure adequate perfusion for nutrient and oxygen delivery to the placenta and thus the fetus. One mode of communication that plays a critical role in regulating Cx43 is the release of endothelial-derived vasodilators such as prostacyclin (PGI2) and nitric oxide (NO) and their respective signaling mechanisms involving second messengers (cAMP and cGMP, respectively) that are likely to be important in maintaining UBF. Therefore, the assertion we present in this review is that GJs play an integral if not a central role in maintaining UBF by controlling rises in vasodilators (PGI2 and NO) via cyclic nucleotides. In this review, we discuss: (1) GJ structure and regulation; (2) second messenger regulation of GJ phosphorylation and formation; (3) pregnancy-induced changes in cell-signaling; and (4) the role of uterine arterial endothelial GJs during gestation. These topics integrate the current knowledge of this scientific field with interpretations and hypotheses regarding the vascular effects that are mediated by GJs and their relationship with vasodilatory vascular adaptations required for modulating the dramatic physiological rises in uteroplacental perfusion and blood flow observed during normal pregnancy.

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Plasma cAMP in Normal and Abnormal Human Pregnancy

Cited by 4 publications

References 19 publications

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>α</sub> and Prostaglandin E<sub>2</sub>

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>α</sub> and Prostaglandin E<sub>2</sub>

Biology of primate relaxin: A paracrine signal in early pregnancy?

Gap Junction Regulation of Vascular Tone: Implications of Modulatory Intercellular Communication During Gestation

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Plasma cAMP in Normal and Abnormal Human Pregnancy

Cited by 4 publications

References 19 publications

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>&alpha;</sub> and Prostaglandin E<sub>2</sub>

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>&alpha;</sub> and Prostaglandin E<sub>2</sub>

Biology of primate relaxin: A paracrine signal in early pregnancy?

Gap Junction Regulation of Vascular Tone: Implications of Modulatory Intercellular Communication During Gestation

Contact Info

Product

Resources

About

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>α</sub> and Prostaglandin E<sub>2</sub>

Changes in Plasma Cyclic AMP and Cyclic GMP during Spontaneous Labor and Labor Induced by Oxytocin, Prostaglandin F<sub>2</sub><sub>α</sub> and Prostaglandin E<sub>2</sub>