Plasma carnitine levels in preterm infants with respiratory distress syndrome

Korkmaz, Ayşe; Tekinalp, Gülsevin; Coşkun, Turgay; Yiğit, Şule; Yurdakök, Murat

doi:10.1111/j.1442-200x.2005.01998.x

Cited by 10 publications

(12 citation statements)

References 15 publications

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“…These results were concordant with those of previous studies that investigated serum L-carnitine levels in patients with or without RDS (2,3). In the present study, serum carnitine levels on day 1 were not associated with the gender of the patients, but did show a negative correlation with birth weight and a positive correlation with Apgar scores.…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies have demonstrated that carnitine is crucially involved in the development of RDS and the carnitine status of patients with RDS (2,3,19). The results of the present study indicated that the duration of mechanical ventilation and the requirement for surfactant therapy was significantly reduced in the groups that received L-carnitine treatment, as compared with the control groups.…”

Section: Discussionsupporting

confidence: 72%

“…This may due to the increased requirement for surfactant synthesis in low birth weight infants as compared with infants with high Apgar scores that exhibit a healthy respiratory pattern. In two previous studies (2,3), no significant differences were reported between L-carnitine levels and gender, birth weight and Apgar scores. Patients with RDS treated with L-carnitine did not exhibit higher serum carnitine levels on day 7 compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Two previous studies have demonstrated that free carnitine levels were reduced in infants with RDS compared with healthy controls (2,3). It has previously been demonstrated that, L-carnitine-betamethasone combination therapies significantly increase the dipalmitoyl phosphatidylcholine content of the foetal lungs and significant reduce the incidence of RDS and mortality in premature newborns, as compared with betamethasone alone (6,9).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous causes of RDS have been identified, and the factors suspected to be involved in the pathogenesis of RDS are numerous (2). In recent years, studies have identified the presence of low serum carnitine levels in preterm newborns with RDS (2,3).…”

Section: Introductionmentioning

confidence: 99%

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Effects of L-carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial

Öztürk

Kardaş²,

Kardaş

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the efficacy of L-carnitine therapy on the occurrence and prognosis of respiratory distress syndrome (RDS). A single blind, randomized controlled trial study was conducted on 130 infants with gestational ages of 28-36 weeks. Infants were assigned to experimental groups (groups 1 and 2) and control groups (groups 3 and 4). Groups 1 and 3 consisted of infants with RDS, and groups 2 and 4 groups were composed of infants without RDS. The experimental groups were treated with carnitine. No statistically significant differences in serum carnitine levels were detected between the study and the control groups on day 1 of treatment (P=0.06). However, on day 7 of treatment, serum carnitine levels in the experimental groups were significantly increased (P= 0.02), as compared with the control groups. The surfactant requirement value, which is how many rounds of surfactant therapy were required, was 1.56±0.97 in group 1, and 2.12±0.99 in group 3 (P<0.001). The mean duration of mechanical ventilation required was 3.04±3.60 days in group 1, and 4.73±5.63 days in group 3 (P<0.001). The present results indicate that carnitine supplementation in premature infants with RDS may help to increase carnitine levels, thus decreasing the duration of mechanical ventilation and surfactant requirement.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of L-carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial

Öztürk

Kardaş²,

Kardaş

et al. 2015

Experimental and Therapeutic Medicine

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Analysis of genetic mutations in Chinese patients with systemic primary carnitine deficiency

Han

Wang

et al. 2014

European Journal of Medical Genetics

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A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Jääskeläinen

Kärkkäinen

Jokkala

et al. 2018

Sci Rep

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Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolomics to determine whether the metabolic profile of plasma from umbilical cord differs between infants born to PE and non-PE pregnancies in the FINNPEC study. Cord plasma was available from 42 newborns born from PE and 53 from non-PE pregnancies. 133 molecular features differed between PE and non-PE newborns after correction for multiple testing. Decreased levels of 4-pyridoxic acid were observed in the cord plasma samples of PE newborns when compared to non-PE newborns. Compounds representing following areas of metabolism were increased in the cord plasma of PE newborns: urea and creatine metabolism; carnitine biosynthesis and acylcarnitines; putrescine metabolites; tryptophan metabolism and phosphatidylcholines. To our knowledge, this study is the first one to apply LC-MS based metabolomics in cord plasma of PE newborns. We demonstrate that this strategy provides a global picture of the widespread metabolic alterations associated with PE and particularly the elevated levels of carnitine precursors and trimethylated compounds appear to be associated with PE at birth.

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Plasma carnitine levels in preterm infants with respiratory distress syndrome

Cited by 10 publications

References 15 publications

Effects of L-carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial

Effects of L-carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial

Analysis of genetic mutations in Chinese patients with systemic primary carnitine deficiency

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

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