Plasma catalase activity and malondialdehyde level in patients with cataract

Ateş, Nurcan Aras; Yıldırım, Özlem; Tamer, Lülüfer; Ünlü, Ali; Ercan, Bahadır; Muşlu, Necati; Kanık, Arzu; Hatungil, Rezan; Atik, Uğur

doi:10.1038/sj.eye.6700718

Cited by 30 publications

(26 citation statements)

References 12 publications

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“…Earlier studies have reported increased levels of the lipid peroxidation product, MDA, in the cataract subjects as compared to those in the controls, which was in accordance with our findings [5,[10][11][12][13]. The high levels of TBARS in the cataractous lenses may, in turn, be the result of the lipid peroxidation of the lens cell membrane, which is produced locally or they may be the consequence of the migration of the products from the retina [14][15][16].…”

Section: Resultssupporting

confidence: 83%

Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Katta

Katkam²,

Geetha³

2013

JCDR

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Background: Cataract is one of the major causes of a visual impairment, which eventually leads to blindness. An oxidative damage to the lens proteins is a major factor which leads to cataract formation. Therefore, we intended to study the relationship between the biochemical markers of oxidative stress and various forms of cataracts. Methods:We examined the lenses and the sera of 120 subjects who were aged 50 to 80 years, who were distributed in two groups, viz. the study group (90 patients) and the control group (30 subjects). The oxidative stress was assessed by estimating the lipid peroxidation product in the form of thiobarbituric acid reactive substances (TBARS), the antioxidant status by measuring the levels of vitamin E and the total antioxidant capacity (TAC). The study group patients were further divided into those with nuclear cataracts (30 patients), cortical cataracts (30 patients), and diabetic cataracts (30 patients).Results: In this study, it was found that the levels of TBARS in the study group were significantly high (p<0.001), whereas the TAC (p<0.001) and the vitamin E (p<0.001) levels were significantly low, both in the lenses and the blood of the study group as compared to those of the control group.

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Section: Resultssupporting

confidence: 83%

Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Katta

Katkam²,

Geetha³

2013

JCDR

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“…31 In the study of Katta AV et al, serum MDA (nmol/ml) values of Mean with SD was significantly higher in 60 patients of senile cataract with 30 cases of nuclear (5.14±1.0) and 30 cases of cortical (3.95±0.71) when compared with 30 normal controls (2.92±0.50). 32 Present study and the above studies showed that the increase in the level of serum MDA is directly related to the progression of the senile cataract.…”

Section: Discussionmentioning

confidence: 99%

Estimation of serum MDA (Malondialdehyde) in various morphological types and clinical stages of age related (senile cataract)

Angirekula

Atti

2018

Int J Adv Med

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Background: The aim was to estimate the Serum Malondialdehyde (MDA) in the various morphological types and clinical stages of Age Related (Senile) Cataract, a common cause of curable blindness, especially in India.Methods: This was a study of estimation of serum Malondialdehyde (MDA) in 100 patients of Age Related (Senile) cataract with 80 cases of Senile Cortical type (40 cases of Posterior subcapsular and 40 cases of Mature) and 20 cases of Senile Nuclear type (10 cases of early Grades of I and II and 10 cases of Advanced Grades of III and IV) and in 20 cases of normal controls in the age group of 45 to 70 years.Results: Serum MDA (nmol/ml) values of the Mean with SD were 3.34±0.93 (Range 2.02-4.65) in normal controls, 4.38±1.01 (Range 2.4 - 6.7) in senile cataract, 4.39±1.02 ((Range 2.4-6.7) in Senile Cortical Cataract with 3.82±0.73 (Range 2.4-5.1) in its Posterior Subcapsular stage and 4.96 ± 0.88 (Range 3.3-6.7) in its mature stage and 4.3±0.99 (Range 2.4-6.2) in Senile Nuclear cataract with 3.68±0.66 (Range 2.4-4.7) in its early Grades of I and II and 4.86±0.94 (Range 3.8-6.2) in its Advanced Grades of III and IV.Conclusions: The present study showed a significant increased concentration of Serum MDA in Senile cataract especially in the advanced later clinical stages or grades of maturity than in the earlier clinical stages or grades of immaturity of senile cortical or nuclear compared to normal controls. And there was no statistically significant difference between the morphological types of Age related (Senile) cataract i.e. Cortical Cataract compared to Nuclear Cataract.

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“…Previous case-control studies were, however, inconclusive about the enrollment of systemic oxidative stress (6,10), and the possible reasons of the disturbed oxidant/antioxidant balance in SC (5,7,8,9,11). It has to be noted that the genesis of SC is of multiple origin, and some etiological risk factors, like visible and UV light exposure, have long-lasting but mostly local effects.…”

Section: Discussionmentioning

confidence: 99%

“…The systemic oxidative stress in SC was previously associated with the decreased activities of superoxide dismutase (7), catalase (8), paraoxonase (9) and GST (11). The majority of blood hydroperoxides are, however, reduced by plasma GPx, and their efficient removal would thus diminish plasma MDA levels as well, as indicated in our study by the significant inverse correlations between plasma GPx, hydroperoxides and MDA.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting light scattering and lens opacification generally resemble the changes seen in human SC (2). Some other oxidants like LPO adducts, including organic hydroperoxides and ma londialdehyde (MDA), also have significant cataractogenic potential (1), and although they can be pre sent in systemic circulation at micromolar le vels and act as toxic messengers, the reports regarding the blood oxidative stress markers in patients with SC are largely inconsistent (5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens Variables

Mirić¹,

Kisic²,

Zoric³

et al. 2012

Journal of Medical Biochemistry

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The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens VariablesOxidative stress is implicated in senile cataract (SC) genesis, although the impact of SC maturity on blood oxidative stress markers is unclear. Total hydroperoxides, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST) were measured in the blood and lens samples of patients having either immature (n=31) or mature SC (n=50), and in 22 blood samples from noncataract controls. Compared to controls, SC patients had higher plasma MDA and serum GST, and decreased plasma GR and GSH levels. Plasma GPx as well as hydroperoxides differed from control values only in patients with mature SC. The multivariate logistic regression analysis showed that the fall of plasma GR activity (OR 5.14; CI 1.82-14.51;p=0.0020), as well as serum GST activity (OR 3.84; CI 1.36-10.83;p=0.0108) were independently associated with the maturity of SC. Lens hydroperoxides, MDA and GST, showed no correlation with correspondent blood values, in contrast to GPx (r=0.715; p<0.001) and GR (r=0.703; p<0.001). This study showed that the severity of SC is associated with increased systemic oxidative stress, which could be due to the fall of GSH-dependent antioxidant enzymes activities.

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Plasma catalase activity and malondialdehyde level in patients with cataract

Cited by 30 publications

References 12 publications

Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Estimation of serum MDA (Malondialdehyde) in various morphological types and clinical stages of age related (senile cataract)

The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens Variables

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