Plasma Catecholamine Responses to Exogenous Histamine in Normal Man

Dalton, N.; Boyce, M. J.; Clancy, Andrew N.; Toseland, P. A.

doi:10.1042/cs061046pb

Cited by 5 publications

(3 citation statements)

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“…Therefore subjects were studied whilst seated in this experiment. We included measurements of plasma adrenaline with the subjects supine to confirm this difference and to test reproducibility with a previous study (Dalton et al, 1981).…”

Section: Methodsmentioning

confidence: 99%

“…Plasma adrenaline was measured at rest and in response to histamine infusion before and after a 2 week course of oral salbutamol. Histamine by infusion was used since it has been suggested that it is preferable to other methods of stimulating the adrenal medulla (Dalton et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

“…Histamine by infusion was used since it has been suggested that it is preferable to other methods of stimulating the adrenal medulla (Dalton et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

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Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Warren¹,

Dalton²,

Turner³

1983

Brit J Clinical Pharma

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1 The adrenal medullary response to intravenous histamine infusions (0.1 and 0.4 micrograms kg‐1 min‐1 histamine base) was studied in six normal subjects. 2 After a 2 week course of oral salbutamol (8 mg slow release twice daily) plasma adrenaline levels, thought to reflect adrenomedullary function, were unchanged both at rest and in response to histamine infusion. 3 The present study does not support our original hypothesis that salbutamol may be capable of suppressing the adrenal medulla in normal subjects.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Warren¹,

Dalton²,

Turner³

1983

Brit J Clinical Pharma

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Administration of H₁ and H₂ Antagonists for Chemoprophylaxis: A Double‐Blind, Placebo‐Controlled Study in Healthy Volunteers

Doenicke

Moss

Toledano

et al. 1997

The Journal of Clinical Pharma

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A double-blind, placebo-controlled trial was performed to establish the duration of action of antihistamines and their ability to attenuate the adverse affects associated with histamine release. Thirty volunteers were assigned randomly to receive either placebo or a combination of the H1 blocker dimetindene maleate (0.1 mg/kg) and the H2 blocker cimetidine (5 mg/kg). A bolus dose of histamine (450 ng/kg) was given 15 minutes after antihistamine or placebo treatment and repeated after 2, 4, and 6 hours. Cardiovascular variables, plasma histamine levels, cutaneous manifestations, and objective and subjective signs and symptoms associated with histamine release were determined before and after each histamine injection. Although many of the signs of histamine release, including erythema and metallic taste, could be attenuated effectively for 6 hours with antihistamine treatment, the protection against histamine-induced flush and headache diminished after 2 hours. Statistically significant protection against histamine-mediated tachycardia persisted for only 2 hours. Antihistamine treatment significantly reduced the increase in plasma histamine levels after the first histamine injection but did not alter the levels after subsequent histamine injections. The currently recommended administration regimen for prophylaxis with antihistamines is insufficient to prevent histamine-mediated side effects, and additional doses may be required after 4 hours to achieve appropriate chemoprophylaxis.

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Pharmacological characterisation of cardiovascular histamine receptors in man in vivo

Boyce¹

1982

Klin Wochenschr

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Data from pharmacological studies carried out in healthy subjects using systemic histamine or impromidine and their antagonists are reviewed. Exogenous histamine by rapid injection appears to stimulate only H1-receptors. Chlorpheniramine alone antagonised the responses to histamine. The effects of cardiovascular H2-receptor stimulation are demonstrated best by a sustained and large dose of histamine given by infusion. If it be considered desirable to antagonise all the cardiovascular responses to endogenous histamine, the available pharmacological data in man suggest this would be achieved best by a combination of an H1-and H2-receptor antagonist.

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Plasma Catecholamine Responses to Exogenous Histamine in Normal Man

Cited by 5 publications

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Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Administration of H₁ and H₂ Antagonists for Chemoprophylaxis: A Double‐Blind, Placebo‐Controlled Study in Healthy Volunteers

Pharmacological characterisation of cardiovascular histamine receptors in man in vivo

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Plasma Catecholamine Responses to Exogenous Histamine in Normal Man

Cited by 5 publications

References 0 publications

Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Effect of a 2 week course of oral salbutamol on adrenomedullary function in normal subjects.

Administration of H1 and H2 Antagonists for Chemoprophylaxis: A Double‐Blind, Placebo‐Controlled Study in Healthy Volunteers

Pharmacological characterisation of cardiovascular histamine receptors in man in vivo

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Administration of H₁ and H₂ Antagonists for Chemoprophylaxis: A Double‐Blind, Placebo‐Controlled Study in Healthy Volunteers