Plasma Catecholamine Responses to Tracheal Intubation

Abstract

Plasma adrenaline and noradrenaline concentrations were measured in 24 patients during the induction of anaesthesia and the subsequent tracheal intubation. The patients received either suxamethonium 1 mg kg-1 or pancuronium 0.1 mg kg-1 to facilitate tracheal intubation. Mean arterial pressure (MAP) increased in both groups following laryngoscopy and tracheal intubation and there were concomitant increases in the plasma catecholamine concentrations, the changes being more marked in the suxamethonium group. There was a significant correlation between MAP and plasma catecholamine concentrations in the suxamethonium group. Measurement of plasma catecholamine concentrations in samples obtained simultaneously from central venous, peripheral venous and arterial sites were in broad agreement; the greatest changes occurred in central venous samples.

Attenuation of the catecholamine response to tracheal intubation with oral clonidine in children

“…has been shown to provide sedation resulting in or from inhibition of CA release in conscious adults, 2~ it is unlikely that oral diazepam (10 mg) premedication attenuates CA changes following intubation in adults. [3][4][5] Thiamylal is a thiobarbiturate which is very similar to thiopentone in chemical structures and 1.1 times as potent as thiopentone. 2] Since two large-scale blinded studies found no difference between these drugs, ~ the difference in potency seems to be too small to achieve no clinical importance.…”

Stress response to tracheal intubation: direct laryngoscopy compared with blind oral intubation

“…Blood samples for the determination of hormonal stress response were taken from a separate intravenous cannula placed in the antecubital fossa after discarding 5 m l of blood at each timepoint. Derbyshire [3] demonstrated that central venous catheterisation is unnecessary when large changes in the catecholamine concentrations are expected and that sampling of blood from a large peripheral vein is acceptable .…”

Effects of propofol on intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism undergoing parathyroidectomy: a randomized control trial

“…8 Mean PTH concentrations in our patients increased in response to anesthetic induction ( Table 2). The catecholamine surge that occurs in response to tracheal intubation 9,10 has been shown to stimulate the PTH secretion. 11 Mahajna et al 11 reported a large increase in serum PTH in patients with normal parathyroid function; however, only female patients with primary HPT experienced a modest albeit statistically significant increase in serum PTH, while this increase was not significant in patients with secondary HPT.…”