Plasma Catecholamines during Sustained Isometric Exercise

Kozłowski, S; Brzezińska, Z; Nazar, K; Kowalski, Wojciech; Franczyk, M.

doi:10.1042/cs0450723

Cited by 69 publications

(31 citation statements)

References 7 publications

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“…The results we obtained were similar to other studies carried out by three other authors; Kozlowski, Petro and Nutter. 14,15,10 Hence our study showed a certain rise in HR during sustained static exercise in both first and second trimesters and then return to steady state in the third trimester, whereas, the BP also showed elevated levels with sustained static exercise though at rest in the first trimester there was fall in BP and in second it was even less. Thus demonstrating a Bi-phasic hemodynamic response during pregnancy in accordance with Kuo's study.…”

Section: Discussionmentioning

confidence: 87%

Blood Pressure and Heart Rate Responses to Sustained Static (Isometric) Contractions by Handgrip Dynamometry in Three Trimesters of Pregnancy

Sarath

Rani

2012

Int Jour of Biomed Res

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Title: Blood pressure and heart rate responses to sustained static (isometric) contractions by handgrip dynamometry in three trimesters of pregnancy. Objective: To measure the blood pressure and heart rate responses at various intensities, in three trimesters of pregnancy to the sustained isometric exercises, by handgrip dynamometry and comparing the results with the controls. Materials and methods: subjects -20 healthy pregnant women, Controls -20 non-pregnant healthy women. Subjects were followed for three trimesters. Blood pressure and heart rate were evaluated with handgrip dynamometer at Rest, 20% and 30% intensities of maximum voluntary contraction and Post Exercise. Blood pressure and Heart rate were recorded with the help of Sphygmomanometer, Stethoscope, and ECG machine. Results: Blood pressure and heart rate increased more during sustained handgrip exercise in Subjects than the Controls. At rest and during static exercise blood pressure reduced in First, Second and increased in Third trimesters, compared to controls. At rest and during static exercise heart rate increased in First, Second trimesters and Third trimester displayed steady levels when compared to the controls. Maximum voluntary contraction in the Controls was higher than the Subjects. Conclusion: Sustained isometric exercise produces an increase in hemodynamics during different trimesters of pregnancy.

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Section: Discussionmentioning

confidence: 87%

Blood Pressure and Heart Rate Responses to Sustained Static (Isometric) Contractions by Handgrip Dynamometry in Three Trimesters of Pregnancy

Sarath

Rani

2012

Int Jour of Biomed Res

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“…3). Other potential sources for this augmented Vo include an increased 02 cost of ventilatory and cardiac muscular work, metabolic stimulation arising from greatly increased catecholamine levels (Kozlowski, Brzezinska, Nazar, Kowalski & Franczyk, 1973), and also the stimulatory effect of hypocapnic alkalaemia on Vo (Cain, 1970;Karetzky & Cain, 1970).…”

Section: Discussionmentioning

confidence: 99%

Control of blood‐gas and acid‐base status during isometric exercise in humans.

Poole¹,

Ward²,

Whipp³

1988

The Journal of Physiology

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SUMMARY 1. At a given level of pulmonary gas exchange, ventilation (VE) is appreciably higher during isometric exercise than during isotonic exercise. It is presently not clear whether the resultant hypocapnia represents a compensatory hyperventilation for an arterial metabolic acidaemia or whether it might reflect a primary respiratory alkalaemia.2. To resolve this issue, five subjects performed isometric leg exercise designed to induce exhaustion in ca. 5 min and, on a separate occasion, ca. 8 min. VE, CO2 output (VCO), 02 uptake (VO ) and end-tidal gas tensions (PET,CO,, PET,O2) were measured breath-by-breath during exercise and recovery; arterialized venous blood (drawn from the dorsum of the heated hand) was sampled frequently and analysed for Pco, PO2, pH, bicarbonate and lactate. These response profiles were compared with those resulting from exhausting bouts of isotonic leg exercise (cycle ergometry) of similar duration.3. The isotonic exercise induced a metabolic (lactic) acidaemia with partial respiratory compensation. In contrast, isometric exercise consistently resulted in a respiratory alkalaemia, with little or no increase of blood [lactate]. At the end of the isometric exercise, VE fell abruptly and then rose again after a short interval (20 s, on average). This secondary stimulation presumably reflected the acid-base consequences of the increased blood [lactate] (3-5 mm, on average) which occurred in the recovery phase.4. We therefore conclude that a primary respiratory alkalaemia occurs during isometric exercise, and that this results from ventilatory stimulation at a time when the 'exercise' metabolites are trapped within the contracting muscles as a consequence of impeded blood flow. The initial rapid reduction of ventilation which occurred at the cessation of the isometric exercise is consistent with a washing-out of 'hyperpnoea-inducing' metabolites from the muscles. Allowing for transit to the central circulation, the reduced ventilation is subsequently supplemented by a powerful humoral drive to breathe which results in a further hyperpnoea and secondary hypocapnia. Because of its latency, we hypothesize that this secondary hypocapnia is of peripheral chemoreceptor origin.5.

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“…This response also occurred after beta-adrenergic blockade, suggesting increased alpha-adrenergic drive or responsiveness as the mechanism involved. Weidman et al (1980) have reported increased cardiovascular reactivity to infused norepinephrine in borderline hypertensive patients and postulated exaggerated peripheral vascular alpha-adrenergic receptor sensitivity as the possible mediator.Indeed, greater alphaadrenergic receptor sensitivity in certain borderline hypertensive patients could contribute to a larger pressor response to static contraction, since this type of circulatory stress is known to evoke increases in plasma norepinephrine levels (Kozlowski et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular response to static contraction in borderline hypertension

et al. 1985

Clinical Cardiology

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Summary: Nine young males with borderline hypertension (BH) (mean agef SD, 25 f5 yr) and 13 young male normotensive controls (NT) (24f3 yr) were studied to determine their cardiovascular responses to small and large muscle static contractions. The subjects performed onearm handgrip and two-leg extension in a randomly assigned order for 3 min at 30 % of maximal voluntary contraction. Mean intra-arterial blood pressure (MABP), heart rate (HR), and tension were measured throughout the contractions. Borderline hypertensive patients had a higher MABP at rest (p<0.005) and at the end of both types of static contractions (p <0.05). The average increases in MABP from rest to the end of exercise (AMABP) were slightly greater for the BH patients (6 mmHg), but these differences were not significant (p > 0.1). However, a greater percentage of BH patients were hyperreactive to handgrip (ABP > 35 mmHg) and leg extension (ABP >40 mmHg) when compared to controls. These data indicate that, in general, young men with borderline hypertension demonstrate normal cardiovascular regulation in response to static contraction, but that a portion of this population may be hyperreactive to this type of circulatory stress.

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Plasma Catecholamines during Sustained Isometric Exercise

Cited by 69 publications

References 7 publications

Blood Pressure and Heart Rate Responses to Sustained Static (Isometric) Contractions by Handgrip Dynamometry in Three Trimesters of Pregnancy

Blood Pressure and Heart Rate Responses to Sustained Static (Isometric) Contractions by Handgrip Dynamometry in Three Trimesters of Pregnancy

Control of blood‐gas and acid‐base status during isometric exercise in humans.

Cardiovascular response to static contraction in borderline hypertension

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