Plasma catecholamines, pH, and blood pressure during cardiac arrest in pigs

Lathers, Claire M.; Tümer, Nihal; Schoffstall, John M.

doi:10.1016/0300-9572(89)90113-5

Cited by 16 publications

(2 citation statements)

References 34 publications

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“…Studies of the pharmacokinetics of IOI show it to be comparable with IV administration both in maximal concentration and speed achieved after identical dosing. 3,[7][8][9][10][11][12][13][14] The November 2005 AHA guidelines 4 even compare it with central venous administration stating that "Intraosseous (IO) cannulation provides access to a noncollapsible venous plexus, enabling drug delivery similar to that achieved by central venous access".…”

mentioning

confidence: 99%

The Use of a Powered Device for Intraosseous Drug and Fluid Administration in a National EMS: A 4-Year Experience

Schwartz

Amir

Dichter

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

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mentioning

confidence: 99%

The Use of a Powered Device for Intraosseous Drug and Fluid Administration in a National EMS: A 4-Year Experience

Schwartz

Amir

Dichter

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

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“…In other studies, pressure effects similar to these have been observed 14-18 . It is important to highlight that blood concentration of endogenous epinephrine and vasopressin increases during CPR 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Experimental Cardiac Arrest Treatment with Adrenaline, Vasopressin, or Placebo

Palácio¹,

Paiva²,

Azevedo³

et al. 2013

Arquivos Brasileiros De Cardiologia

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BackgroundThe effect of vasoconstrictors in prolonged cardiopulmonary resuscitation (CPR) has not been fully clarified.ObjectivesTo evaluate adrenaline and vasopressin pressure effect, and observe the return of spontaneous circulation (ROSC).MethodsA prospective, randomized, blinded, and placebo-controlled study. After seven minutes of untreated ventricular fibrillation, pigs received two minutes cycles of CPR. Defibrillation was attempted (4 J/kg) once at 9 minutes, and after every cycle if a shockable rhythm was present, after what CPR was immediately resumed. At 9 minutes and every five minutes intervals, 0.02 mg/kg (n = 12 pigs) adrenaline, or 0.4 U/kg (n = 12) vasopressin, or 0.2 mL/kg (n = 8) 0.9% saline solution was administered. CPR continued for 30 minutes or until the ROSC.ResultsCoronary perfusion pressure increased to about 20 mmHg in the three groups. Following vasoconstrictors doses, pressure level reached 35 mmHg versus 15 mmHg with placebo (p < 0.001). Vasopressin effect remained at 15-20 mmHg after three doses versus zero with adrenaline or placebo. ROSC rate differed (p = 0.031) among adrenaline (10/12), vasopressin (6/12), and placebo (2/8). Time-to-ROSC did not differ (16 minutes), nor the number of doses previously received (one or two). There was no difference between vasoconstrictors, but against placebo, only adrenaline significantly increased the ROSC rate (p = 0.019).ConclusionThe vasoconstrictors initial pressure effect was equivalent and vasopressin maintained a late effect at prolonged resuscitation. Nevertheless, when compared with placebo, only adrenaline significantly increased the ROSC rate.

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