Plasma Cell Gingivitis: Treatment with Chlorpheniramine Maleate

Ranganathan, Aravindhan T; Chandran, Chitraa R; Prabhakar, Priya; Lakshmiganthan, Mahalingam; Parthasaradhi, Thakkalapati

doi:10.11607/prd.2111

Cited by 6 publications

(2 citation statements)

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“…The published literature showed 43 reported cases of PCG from 1971 to 2020 [ Supplementary Table 1 ]. [ 1 4 5 6 7 9 11 15 16 17 18 19 20 21 22 23 24 25 27 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 ]…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Mishra

Gupta

Kaur

et al. 2022

Journal of Indian Society of Periodontology

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Background: This study aims to describe the demographics and clinicopathological characteristics of the cases of plasma cell gingivitis (PCG) reported in our institute, supported by a review of pertinent literature. Further, we investigated the role of the cluster of differentiation CD138, Ki67, CD56, and CD117 immunoexpression in the differential diagnosis of PCG from plasma cell dyscrasias. Materials and Methods: All histopathologically confirmed cases of PCG, whose relevant details could be obtained, were included in this study. They were subjected to panel of immunohistochemical markers to exclude plasma cell malignancies. Further, published English literature for PCG since 1970–2020 was reviewed. Results: Nine histopathologically confirmed cases of PCG, were retrieved from the archives of our department. The cases comprised 3 males and 6 females with their ages ranging between 14 and 82 years. The plasma cells exhibited equivocal reactivity for kappa and lambda; and immunonegativity for CD56, CD117 with low Ki67 proliferation index. Published literature in English showed 43 cases of PCG were predominantly female; the diffuse involvement of maxilla and mandible was a common finding. Conclusion: In addition to kappa lambda reactivity, an immunoprofile of CD138, Ki67, CD56, and CD117 may be used as a diagnostic adjunct to exclude malignant plasma cell lesions in confusing cases.

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Section: Resultsmentioning

confidence: 99%

Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Mishra

Gupta

Kaur

et al. 2022

Journal of Indian Society of Periodontology

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“…Identification of the potential irritant (herbal toothpaste, chewing-gum, spicy foods, or dental bacterial plaque) during anamnestic collection represents the first essential step of the therapeutic strategy. As indicated in numerous cases, when the etiological factor is identified, the treatment consists of the removal of the same, which is often followed by resolution [ 18 , 20 , 32 , 33 ]. However, this does not always occur and, therefore, it is possible to resort to the use of surgical or pharmacological strategies at a later stage [ 17 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pitfalls and Challenges in Oral Plasma Cell Mucositis: A Systematic Review

Coppola

Cantile

Canfora

et al. 2022

JCM

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Plasma cell mucositis (PCM) is an unusual idiopathic disorder characterized by dense infiltrates of plasma cells in submucosa. Clinical phenotypes of oral plasma cell mucositis (o-PMC) are heterogenous. A systematic review has been conducted, aiming to synthesize the available evidence on o-PCM. Literature search, study design, and data analysis were performed following PRISMA guidelines. The SPIDER and the PICO tools were used to structure the research question. In all, 79 case reports and 19 case series on a total of 158 patients (85 females and 73 males; average age: 44.1 years) were identified. Among oral sites involved, gingiva (65.82%) was the most frequent site. The main clinical phenotype was erythema (99.37%). In relation to symptoms, pain (60.76%) was the most reported. On histological examination, all samples showed a dense inflammatory infiltration with predominant plasma cells. The treatment regimens of o-PCM were summarized in six groups: irritant removal; topical/systemic corticosteroids; topical/systemic immunosuppressants/immunomodulators; surgery and similar treatments; radiotherapy and chemotherapy; other therapies, such as antifungals, antibiotics, and antivirals drugs. This is the first systematic review aimed to synthesize the findings of studies on o-PCM. The lack of universally shared information on etiological factors and the absence of international consensus of pharmacological protocols make o-PCM a diagnostic and therapeutic challenge.

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