Plasma cell granuloma of lower lip: A rare case entity

Abstract

Plasma cell granuloma is a benign non-neoplastic lesion which is described under the pseudo-inflammatory tumor category. The etiologies of this lesion are complex and still remain unclear. It occurs primarily in lungs, but also been reported in other extrapulmonary sites. In oral cavity, plasma cell granuloma is exceedingly rare and present as a rapidly growing mass which show aggressive behavior and mimic a malignant tumor, posing a diagnostic dilemma. Histologically, it is composed of polyclonal plasma cells with variable components of fibroblast and myofibroblast, owing to microscopic diversity and thus inconsistent nomenclature. Simple excision plasma cell granuloma is curative with no evidence of recurrence. This is a case report of plasma cell granuloma of lower lip in a 62 years old female patient which was initially diagnosed as carcinoma of lip because of its clinical ulceroproliferative form. However, detailed radiographic and histological investigation diagnosed it to be plasma cell granuloma of lower lip.

Clinicopathological Study of Oral Plasma Cell Granuloma

“…Mostly, they have been recorded as single case reports. Oral plasma cell granuloma has been represented in the tongue, 5 lip, 6 oral mucosa, 1 and gingiva. 7,16 The demographic data analysis of the current study groups of OPCG revealed that the ages were found to range from 11 to 73 years with a mean of 42.40 years.…”

“…3 The occurrence of PCG in the head and neck region is also rare. Oral plasma cell granuloma has been reported to be rarely seen in the oral cavity, as a single unilateral swelling seen primarily on the periodontal tissue, mainly the gingiva, 4 followed by the tongue, 5 lips, 6 buccal and oral mucosa. 1 These lesions have been observed to have no gender predilection and might occur at any age.…”