Plasma Cell Granuloma of the Lung

Mehta, Jayant B.; Desphande, SS; Stauffer, John; Stanford, Ray E.; Fernandez, Enrique Fabian

doi:10.1097/00007611-198009000-00009

Cited by 27 publications

(3 citation statements)

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“…[ 24 ] reported an unusual case of a 71 year-old with severe COPD treated with 18 Gy in 9 fractions following local recurrence from bronchoscopic resection. A Further 30 Gy in 10 fractions was given six months later due to persistent disease on bronchoscopic examination [ 24 ]. Two years on patient continued to have stable disease [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…A Further 30 Gy in 10 fractions was given six months later due to persistent disease on bronchoscopic examination [ 24 ]. Two years on patient continued to have stable disease [ 24 ]. Had the patient received radical dose upfront, patient may have developed better disease control, however this was an unusual case presenting in a 71 year-old with fitness precluding radical treatment.…”

Section: Discussionmentioning

confidence: 99%

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Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

Tong,

Chisholm,

Madden

et al. 2024

J Med Case Reports

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Background Pulmonary inflammatory myofibroblastic tumour (IMT) is a rare condition that usually presents in young individuals and is associated with anaplastic lymphoma kinase (ALK)-translocation. Case presentation We report a case of an 18-year-old Caucasian man with ALK-translocated pulmonary IMT treated with multimodality therapy. The patient presented with breathlessness and was found to have a collapsed left lung. Further investigations revealed an ALK-translocated pulmonary IMT. This is usually treated with an ALK-inhibitor but patient declined after discussing potential side-effects and had repeated rigid bronchoscopic interventions for local disease control. Due to persistent local recurrence, patient received radical external beam radiotherapy (EBRT) with pulse steroids, and one year later started on Ibuprofen, a non-steroidal anti-inflammatory agent (NSAID). Following multimodality treatment, he developed a complete response. He remains treatment-free for the past seven years. Eleven years on from his diagnosis, he remains in remission with a ECOG performance status of zero. Conclusions Achieving long-term local control in pulmonary IMT can be challenging. Multimodality treatment is sometimes needed but the overall outlook remains good.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

Tong,

Chisholm,

Madden

et al. 2024

J Med Case Reports

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“…Russell bodies, indicating the accumulation of plasma cell secretory product, have been frequently noted (2,19). Immunohistochemical stains can dem- (18) esop hagus (16), steroids (21,22), radiation (7,23,24), cyclosporine (25), liver transplantation (26), and nonsteroidal antiinflammatory drugs (27) has been reported. The efficacy of these treatments is difficult to assess given the frequent spontaneous regression seen in the absence of adjuvant therapy (28,29).…”

Section: Fig 2 Section From Stomach Wall Shows Interdigitating Fascic...mentioning

confidence: 99%

Gastric Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor) in Infancy

Riedel,

Wong,

1994

J. pediatr. gastroenterol. nutr.

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Treatment of plasma cell granuloma of the lung with radiation therapy. A report of two cases and a review of the literature

Imperato

Folkman

Sagerman

et al. 1986

Cancer

112

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Plasma cell granuloma is a rare, benign tumor that affects people at all ages and most frequently involves the lung, gastrointestinal tract, and salivary gland. They are the most common, isolated, primary lesion of the lung in children less than 16 years of age, and usually present as circumscribed, peripheral, parenchymal tumors, which may be static or increase slowly in size without causing symptoms. Whereas surgical excision is the treatment of choice, there are situations in which the lesion cannot be resected without significant morbidity because of direct extension into the mediastinum or lymph nodes. In these circumstances, radiation therapy may be a better therapeutic option. Two cases of plasma cell granuloma that could not be completely resected are described. The patients were treated with radiation therapy consisting of 4320 rad in 4.5 weeks and 4500 rads in 4.5 weeks, respectively, and both have been cured. Although surgery as the primary treatment for most patients is still recommended, especially in the young so the potential side effects of radiation therapy can be avoided, the authors believe that in rare cases where the lesion is locally aggressive and surgically unresectable or resectable only with major morbidity, radiation therapy can be an effective alternative. Currently, the recommended treatment is 4000 to 4500 rad given in 180 to 200 rad fractions, with the fields being carefully tailored to tumor volume in order to minimize the dose to the surrounding normal tissue.

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Plasma Cell Granuloma of the Lung

Cited by 27 publications

References 0 publications

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

Gastric Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor) in Infancy

Treatment of plasma cell granuloma of the lung with radiation therapy. A report of two cases and a review of the literature

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