Plasma Cell Granuloma of the Lung in Children

Monzon, Carlos M.; Gilchrist, Gerald S.; Burgert, E. Omer; O’Connell, Edward J.; Telander, Robert L.; Hoffman, Alan D.; Li, Chin‐Yang

doi:10.1542/peds.70.2.268

Cited by 50 publications

(10 citation statements)

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“…Radiologic findings of IMT of the lung in children have been described in previously published studies. [4][5][6][7]17,18,21 However, our study was conducted using cases from a study period encompassing the modern pathologic definition of "inflammatory myofibroblastic tumor," ensuring a pure population of well-vetted tumors fitting this category. This sets our study apart from many of the previously published studies on pediatric IMT and may explain some of the differences in imaging findings.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the results of our study, which focused on thoracic MDCT findings, with the largest pediatric patient population at the present time, provide new, more specific information on the characteristic MDCT attributes of IMT of the lung in children, many of which differ from the findings of previously published studies obtained with either single-detector CT, mixed pediatric and adult population, or overall smaller patient population size. [4][5][6][7]17,18,[21][22][23][24]31,32 First, a previously published study by Agrons et al 6 consisting of both pediatric and adult patients stated that IMT of the lung has an anatomic bias for the lower lobes. In contrast, the results of our study show that there is no significant lobar preference in pediatric patients with IMT of the lung.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Currently, published descriptions of the imaging findings of IMT of the lung in children have been limited to case reports and small studies. 4,5,[11][12][13][17][18][19][20][21][22][23][24] Furthermore, to our knowledge, no large study specifically investigating the characteristic thoracic MDCT features of IMT of the lung has been published since the advent of MDCT, which can provide improved characterization of lung masses with high temporal and spatial resolution and contrast enhancement pattern. Therefore, the purpose of this study is to investigate the characteristic thoracic MDCT findings of pathologically proven IMT of the lung in children in the era of modern understanding based on refined pathologic diagnosis.…”

mentioning

confidence: 99%

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Thoracic Multidetector Computed Tomography Evaluation of Inflammatory Myofibroblastic Tumor of the Lung in Pediatric Patients in the Era of Modern Diagnosis

Lee¹,

Vargas

Park³

et al. 2021

Journal of Thoracic Imaging

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Purpose: The purpose of this study was to investigate the characteristic thoracic multidetector computed tomography (MDCT) findings of pathologically proven inflammatory myofibroblastic tumor (IMT) of the lung in children in the era of modern understanding based on refined pathologic diagnosis.Materials and Methods: All pediatric patients (age 18 y and above) with a known pathologic diagnosis of IMT of the lung who underwent thoracic MDCT studies from May 2008 to December 2020 were included. Two pediatric radiologists independently evaluated thoracic MDCT studies for the presence of abnormalities in the lung (nodule, mass, cyst, ground-glass opacity, consolidation), pleura (pleural effusion, pneumothorax), and mediastinum and hilum (lymphadenopathy). When a lung abnormality was present, the number, size, composition (solid, cystic, or combination of both), location (laterality, lobar distribution, and intraparenchymal vs. pleural-based), borders (well-circumscribed vs. ill-defined), the presence and type of associated calcification (punctate, dense, curvilinear, or flocculent), the presence of associated cavitation, contrast enhancement pattern (homogeneous, heterogenous, central, or peripheral), and other associated findings (neural foramen involvement, anomalous vessels, mass effect, and invasion of adjacent thoracic structures) were also evaluated. Interobserver agreement between 2 independent reviewers was evaluated with κ statistics.Results: In all, 12 thoracic MDCT studies from 12 individual pediatric patients (5 males [42%] and 7 females [58%]; mean age: 9.9 y; SD: 4.4 y; range: 2 to 16 y) comprised the final study population. All 12 thoracic MDCT studies (100%) were performed with intravenous contrast. The most frequent MDCT finding of IMT of the lung in children is a solitary (92%), pleural-based (83%), wellcircumscribed (100%), solid (92%) mass with heterogenous contrast enhancement (100%), often with dense calcification (50%), which occurred in both lungs and all lobes with similar frequency. No pleural abnormality (pleural effusion, pneumothorax) or mediastinal abnormality (lymphadenopathy) was detected. In addition, although mass effect on adjacent thoracic structures was frequently seen (42%), no invasion, neural foramen involvement, or associated anomalous vessels was identified. There was excellent interobserver κ agreement between 2 independent reviewers for detecting abnormalities on thoracic MDCT studies (κ > 0.95).Conclusions: IMT of the lung in children typically presents as a solitary, pleural-based, well-circumscribed, solid mass with heterogenous contrast enhancement, often with dense calcification, without significant laterality or lobar preference. In addition, pleural or mediastinal abnormalities are characteristically absent. These notable MDCT attributes of IMT of the lung are an important and novel finding, with great potential to help differentiate pediatric IMT of the lung from other thoracic masses in children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Thoracic Multidetector Computed Tomography Evaluation of Inflammatory Myofibroblastic Tumor of the Lung in Pediatric Patients in the Era of Modern Diagnosis

Lee¹,

Vargas

Park³

et al. 2021

Journal of Thoracic Imaging

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“…Approximately 25 % of patients will present with a coin lesion (4). The tumor size may range from 0.5 to 36 cm (5,6). The pulmonary mass can grow quite large, occupying entire lung.…”

Section: Ijri 16:1 February 2006mentioning

confidence: 99%

“…Calcification was present in 2 cases, both of there were children. Monzon et al; in reporting 28 children with inflammatory pseudotumor, described calcification in 4 children (6). Berardi and colleagues reviewed 181 of inflammatory pseudotumor and found 8 instances of calcification.…”

Section: Ijri 16:1 February 2006mentioning

confidence: 99%