Plasma cell granuloma of the stomach.A report of a case and review of the literature

Sakata, Jun; Saito, Kenkichi; Suzuki, Norihiro; Sakai, Tetsuro

doi:10.1002/1097-0142(197003)25:3<618::aid-cncr2820250317>3.0.co;2-r

Cited by 79 publications

(16 citation statements)

References 9 publications

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“…Few such cases, however, have appeared in the literature and most of them have been in the lung and upper respiratory tract (Ash, Beck, and Wilkes, 1964). The only cases reported from the abdomen were one in the liver described by Pack and Baker (1953) and recently a gastric lesion reported by Soga, Saito, Suzuki, and Sakai (1970). This paper reports two cases observed in the abdomen.…”

mentioning

confidence: 75%

Inflammatory pseudo-tumours of the abdomen: plasma cell granulomas

Wu¹,

Yunis²,

Fetterman³

et al. 1973

J Clin Pathol

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mentioning

confidence: 75%

Inflammatory pseudo-tumours of the abdomen: plasma cell granulomas

Wu¹,

Yunis²,

Fetterman³

et al. 1973

J Clin Pathol

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“…The histological features of plasma cell granuloma are mature plasma cells without mitosis scattered throughout the lesions, and spindleshaped cells. 1,6 On the other hand, malignant plasma cell tumors are characterized by the pleomorphism of plasma cells and by the presence of marked mitosis. The best criterion for evaluation is the immunohistochemical analysis of clonal constitutions.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning the alimentary tract, plasma cell granuloma has been reported in the esophagus, [9][10][11] stomach, [6][7][8][12][13][14][15][16][17] and colon. 18 The lesions ranged in size from 4.2 to 10 cm in the stomach and a lesion of 0.8 cm was reported in the cecum, but none, apart from the lesion in our patient, had extended to induce gastrointestinal obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact pathogenesis of plasma cell granuloma remains uncertain, it is considered to be inflammatory in nature. 1 It has been reported that gastric plasma cell granulomas were often associated with mucosal ulceration; 6,8,12 however, the ulcer may be a secondary phenomenon, since some patients were free from ulcers, and plasma cell granulomas are very rare compared to gastric ulcers. It seems that mucosal ulceration probably represented the underlying cause of the reactive process and resulted in the formation of plasma cell granuloma.…”

Section: Discussionmentioning

confidence: 99%

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Colonic obstruction induced by plasma cell granuloma of the transverse colon: Report of a case

et al. 1998

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Plasma cell granuloma is mainly composed of reactive plasma cell proliferation, the origin of which is uncertain. Immunohistochemically, the plasma cells are characterized by a polyclonal nature, and must be distinguished from plasmacytoma which displays a monoclonal nature. This tumor is most commonly found in the lung and bronchus, but has rarely been described in the alimentary tract. We report herein a case of plasma cell granuloma of the transverse colon. A 71-year-old woman was admitted for lower abdominal pain with severe inflammation and anemia. Ultrasound examination and computed tomography showed an abdominal tumor. Barium enema revealed the tumor to be located in the transverse colon causing colonic obstruction. The resected tumor was spherical and mainly spread in the submucosal layer. Microscopically, the tumor consisted of severe infiltration of mature plasma cells within the spindle-shaped myofibroblasts. Immunohistochemical studies showed IgA, IgG, IgM, and kappa and lambda chains, and revealed a polyclonal nature of the plasma cells. Thus, a pathological diagnosis of plasma cell granuloma affecting the transverse colon was made. To the best of our knowledge, this is the first report of successful surgical resection of plasma cell granuloma of the colon.

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“…It primarily occurs in the lungs [2]. It is also seen to occur in the brain [3], kidney [4], stomach [5] and heart [6].…”

Section: Introductionmentioning

confidence: 99%

Value of Immunohistochemistry in Diagnosing a Rare Case of Maxillofacial Plasma Cell Granuloma Masquerading as a Gingival Epulis

Jeyaraj

Bandyopadhyay

Naresh

et al. 2013

J. Maxillofac. Oral Surg.

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Background Plasma cell granuloma is a non-neoplastic lesion rather uncommonly seen in the maxillofacial region. Its etiology, biological behavior, ideal treatment and prognosis are still unclear and rather controversial. Study A detailed histopathological examination and immunohistochemical study of the excised specimen was carried out, both for making a confirmatory diagnosis as well as to determine the etiopathology, biological behavior and prognosis of the lesion. Results Light microscopy revealed a hyperplastic stratified squamous epithelial lining, overlying a densely fibrocellular granulation tissue containing a rich proliferation of mononuclear inflammatory cells, among which there was a predominance of plasma cells with their typical eccentric, cartwheel shaped, ''clock-faced'' nuclei. Strong immunohistochemical positivity was observed for CD-138 by numerous cells of the connective tissue of the lesion, thus confirming them to indeed be plasma cells. Further, immunohistochemistry (IH) analysis also demonstrated the expression of both, the lambda and kappa light chain immunoglobulins by the plasma cell population, thus confirming them to be polyclonal and of an inflammatory, non-neoplastic origin. Summary and ConclusionAs a plasma cell granuloma is rarely encountered in the oral and maxillofacial region, its diagnosis could have been very easily missed, had it not been for the detection of the large numbers of plasma cells by light microscopy, which was further confirmed by IH. IH also helped in establishing the likely etiopathology of the lesion and confirmed it to be of a non-neoplastic reactive/inflammatory origin.

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Plasma cell granuloma of the stomach.A report of a case and review of the literature

Cited by 79 publications

References 9 publications

Inflammatory pseudo-tumours of the abdomen: plasma cell granulomas

Inflammatory pseudo-tumours of the abdomen: plasma cell granulomas

Colonic obstruction induced by plasma cell granuloma of the transverse colon: Report of a case

Value of Immunohistochemistry in Diagnosing a Rare Case of Maxillofacial Plasma Cell Granuloma Masquerading as a Gingival Epulis

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