Plasma Cell Precursors: Long-Distance Travelers Looking for a Home

Luther, Sanjiv A.

doi:10.1016/j.immuni.2010.07.010

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Fooksman et al (28) have described the persistent linear tracks of PBs in the LN T zone followed by the slower and much more confined migration of PBs/PCs once they have reached MCs (37). We confirm these findings, and propose that the different migration strategy can be explained at least in part by PBs/PCs being physically guided initially by the TRC and later by the MedRC network, similar to the reported naive lymphocyte migration along TRCs and FDCs (17).…”

Section: Discussionsupporting

confidence: 86%

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Huang

Rivas-Caicedo

Renevey

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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104

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Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. The early PCs are retained within the reactive lymphoid organ where their localization and homeostasis rely on extrinsic factors, presumably produced by local niche cells. While myeloid cells have been proposed to form those niches, the contribution by colocalizing stromal cells has remained unclear. Here, we characterized a subset of fibroblastic reticular cells (FRCs) that forms a dense meshwork throughout medullary cords of lymph nodes (LNs) where PCs reside. This medullary FRC type is shown to be anatomically, phenotypically, and functionally distinct from T zone FRCs, both in mice and humans. By using static and dynamic imaging approaches, we provide evidence that medullary FRCs are the main cell type in contact with PCs guiding them in their migration. Medullary FRCs also represent a major local source of the PC survival factors IL-6, BAFF, and CXCL12, besides also producing APRIL. In vitro, medullary FRCs alone or in combination with macrophages promote PC survival while other LN cell types do not have this property. Thus, we propose that this FRC subset, together with medullary macrophages, forms PC survival niches within the LN medulla, and thereby helps in promoting the rapid development of humoral immunity, which is critical in limiting early pathogen spread.

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Section: Discussionsupporting

confidence: 86%

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Huang

Rivas-Caicedo

Renevey

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

104

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“…The current identification of Ig-producing prePBs, lacking CD20 and CD38, would allow for the precise location and traffic of these prePBs, compared with CD38 + PBs and then CD38 + CD138 + plasma cells. PrePBs also express LFA-1 (ITGAL/ ITGB2) and VLA-4 (ITGA4/ITGB1) integrins that could drive plasma cell motility within lymph node through ICAM1/2 or VCAM-1 gradient (10,38).…”

Section: Cd8amentioning

confidence: 99%

Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation

Jourdan

Caraux

Caron

et al. 2011

The Journal of Immunology

131

171

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The early steps of differentiation of human B cells into plasma cells are poorly known. We report a transitional population of CD20low/−CD38− preplasmablasts along differentiation of human memory B cells into plasma cells in vitro. Preplasmablasts lack documented B cell or plasma cell (CD20, CD38, and CD138) markers, express CD30 and IL-6R, and secrete Igs at a weaker level than do plasmablasts or plasma cells. These preplasmablasts further differentiate into CD20−CD38highCD138− plasmablasts and then CD20−CD38highCD138+ plasma cells. Preplasmablasts were fully characterized in terms of whole genome transcriptome profiling and phenotype. Preplasmablasts coexpress B and plasma cell transcription factors, but at a reduced level compared with B cells, plasmablasts, or plasma cells. They express the unspliced form of XBP1 mRNA mainly, whereas plasmablasts and plasma cells express essentially the spliced form. An in vivo counterpart (CD19+CD20low/−CD38−IL-6R+ cells) of in vitro-generated preplasmablasts could be detected in human lymph nodes (0.06% of CD19+ cells) and tonsils (0.05% of CD19+ cells). An open access “B to Plasma Cell Atlas,” which makes it possible to interrogate gene expression in the process of B cell to plasma cell differentiation, is provided. Taken together, our findings show the existence of a transitional preplasmablast population using an in vitro model of plasma cell generation and of its in vivo counterpart in various lymphoid tissues.

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“…Here, GCs undergo a reaction to increase Ig affinity with the help of T cells to produce either memory B cells or affinitymatured long-lived PCs, (Figure 2) which migrate to specialized niches in the bone marrow that help maintain survival. 21 PCs can be divided into two subsets, namely short-and longlived PCs, according to their life spans. 22,23 Both short-and long-lived PCs have critical humoral immunity roles in the defense against foreign pathogens.…”

Section: Pc Differentiation: the Importance Of T Cells Cytokines Andmentioning

confidence: 99%

IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation

Deng

Wei

2014

Cell Mol Immunol

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Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.

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Plasma Cell Precursors: Long-Distance Travelers Looking for a Home

Abstract: Little is known about the migration of plasma cell precursors to the lymph node medulla. In this issue of Immunity, Fooksman et al. (2010) propose that this migration is largely independent of chemotactic cues but follows a long linear walk of random orientation.

Cited by 4 publications

References 10 publications

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation

IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation

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