Plasma chemerin level in metabolic syndrome

Abstract

ABSTRACT. To investigate the chemerin level in the ChineseHan population with metabolic syndrome and its relationship with each metabolic syndrome component [body mass index (BMI), blood pressure, blood lipids, and blood glucose], we selected 30 patients with metabolic syndrome and 30 healthy control subjects. The chemerin level was measured by enzyme immunoassay in these 2 groups. The subjects' weight, blood pressure, BMI, waist circumference, fasting blood glucose, fasting insulin, lipids, and glycated hemoglobin were simultaneously detected. The t-test, correlation analysis, and multiple regression analysis were used to perform statistical analysis. We found that plasma chemerin level was higher in the metabolic syndrome group than that in the control group (97.61 ± 6.49 vs 70.26 ± 6.97, t = 15.73, P < 0.05). The plasma chemerin level was positively correlated with systolic blood pressure, waist circumference, BMI, waist-to-hip ratio, fasting blood glucose, fasting insulin, and glycated hemoglobin (r = 0.548, 0.442, 0.359, 0.556, 0.613, 0.581, and 0.572, respectively; all P < 0.05). However, it was negatively correlated with high-density lipoprotein cholesterol (r = -0.378, P < 0.05). Therefore, we concluded that plasma chemerin level was correlated with obesity, blood pressure, and high-density lipoprotein cholesterol, suggesting that it may play a role in the

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

“…High blood pressure could be a potential link given that it contributes both to metabolic syndrome and is a major risk factor for cardiovascular disease. Circulating chemerin concentration positively correlates with both systolic and diastolic blood pressure in a range of patient populations, particularly those with obesity, metabolic syndrome, type 2 diabetes mellitus, and type 2 diabetes mellitus with hypertension, and these patient groups are at higher risk of developing cardiovascular disease. Our data show, for the first time, that chemerin causes concentration‐dependent contraction of human blood vessels and has a direct effect on blood pressure in rats by binding to CMKLR1 on the smooth muscle layer.…”

Serum chemerin and high-sensitivity C reactive protein as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes

“…Dysregulation of these pro-inflammatory and anti-inflammatory substances in obesity may serve as a link between obesity, insulin resistance and cardiovascular disease (CVD) [Roh et al 2007]. Chemerin is a one of the adipokines that regulates fat formation and metabolism and affects the metabolism of fat-cell differentiation and adipose-tissue inflammatory response through the paracrine and autocrine systems [Wang et al 2013].…”

“…On the other hand, chemerin was identified for its role in inducing insulin resistance from studies on human skeletal muscles [Wang et al 2013]. It has three types of receptors: chemokine-like receptor 1 (CMKLR1), serpentine chemokine (CC motif) receptor-like 2 (CCRL2), and G protein-coupled receptor 1 (GPR1).…”

The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension

“…Potency and efficacy of Chemerin-9, NE, and ACh in aortic rings from male and female WT and KO rats 10.6 7.11 6 0.06* 113.5 6 3.6* 6 16. 6 0.18 40.7 6 7.6 † 6.79 6 0.18* 59.5 6 7.8* , † NE 7.65 6 0.16 143.1 6 2.3 7.67 6 0.16 170.1 6 27.0 8.32 6 0.16 159.9 6 0.12 18.91 6 5.2 † 7.34 6 0.04 16.0 6 1.00 †…”