Plasma chemerin levels in rheumatoid arthritis are correlated with disease activity rather than obesity

Ha, You Jung; Kang, Eun Jin; Song, Jung Soo; Park, Yong Bum; Lee, Soo Kon; Choi, Sang Tae

doi:10.1016/j.jbspin.2013.07.013

Cited by 31 publications

(30 citation statements)

References 9 publications

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“…Chemerin was recently isolated and is considered to be a new member of the adipocytokine family [13,14]. Circulating chemerin levels are higher in patients with metabolic syndrome, obesity, gestational diabetes mellitus, type 2 diabetes mellitus with hypertension, rheumatoid arthritis, and chronic pancreatitis [22–26]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns

et al. 2014

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BackgroundChemerin is a novel adipokine that plays a role in inflammation and atherosclerosis. Although there are several correlations between hypertension and the inflammatory system, there is still insufficient information about the relationship between blood pressure variability and inflammatory markers. In this study, we aimed to determine whether chemerin levels are elevated in non-dipper patients compared with dippers and healthy controls.Material/MethodsThis study was composed of a group of 90 patients: 60 hypertensive patients and 30 healthy control subjects (12 males, mean age 53.2±15.4 years). Ambulatory blood pressure monitoring devices (ABPM) were connected to all patients. Using data from the ABPM, hypertensive patients were divided into 2 groups: 30 dipper patients (12 males, mean age 52.5±15.1 years) and 30 non-dipper patients (11 males, mean age 54.6±13.0 years). Complete blood count and biochemistry were measured by standard methods and plasma chemerin concentrations were quantified by ELISA.ResultsNon-dipper patients demonstrated higher chemerin levels compared to dippers and normotensives (219.7±16.3 vs. 182.4±21.4 ng/ml; 219.7±16.3 vs. 85.4±38.1 ng/ml, respectively, p<0.001 for both comparisons). A receiver operating characteristic curve analysis revealed that the optimal cut-off value for chemerin to predict a non-dipping pattern was 201.4, with 90% sensitivity and 90% specificity. There was a positive correlation between chemerin levels and all ambulatory blood pressure values in all hypertensive patients.ConclusionsChemerin, which plays a role in inflammation and atherosclerosis, was higher in non-dippers compared to dippers and normotensives. Additionally, chemerin shows positive correlations with blood pressure.

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Section: Discussionmentioning

confidence: 99%

Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns

et al. 2014

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“…Compared to osteoarthritis, chemerin and ChemR23 are highly expressed in RA synovial fluid with high production by local fibroblasts [59] and could be used as a biomarker of RA [60]. Because of the wide variety of other pathologies that may increase serum chemerin, its use as a biomarker for RA is not practical, but the chemerin expansion beyond the synovial fluid indicates chemerin may be involved in the global recruitment of the immune cells.…”

Section: - Pathophysiologymentioning

confidence: 99%

Chemerin: A comprehensive review elucidating the need for cardiovascular research

Ferland

Watts

2015

Pharmacological Research

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When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influence capable of regulating chemotactic, adipokine, autocrine/paracrine, adipogenic, angiogenic, and reproductive functions. These individual abilities of chemerin are important for understanding its basic pharmacology and physiology, but application of these principles to human pathology relies on the ability of scientists and physicians to view this protein from a much wider, all-encompassing angle. A global participant in the action of chemerin is the cardiovascular system (CVS). Although the CVS may not have as many direct interactions (e.g. smooth muscle in endothelium) with chemerin as it does indirect (e.g. chemerin activation in the lumen by proteases), our basic understanding of the CVS and its relation to chemerin is necessary to form a proper grasp of its individual actions and make the applications to pathology. This review provides a fundamental, yet comprehensive review of chemerin that inherently identifies the CVS as a necessary link between chemerin and its associated pathologies, but also calls for basic cardiovascular research as the solution to this chasm between knowledge and application.

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“…Therefore, these observations indicate that chemerin may be involved in the enhancement of local pro-inflammatory cytokine and chemokine production by RA FLSs, leading to persistent amplification of inflammation in the RA synovium, possibly in an autocrine or paracrine manner. Recently, Ha et al found that chemerin levels directly correlate with disease activity in RA (73). However, it is not yet completely clear whether the circulating levels of chemerin in patients with RA are more associated with systemic inflammation or AT itself, but it is confirmed its role as a biomarker of disease activity.…”

Section: Pedf and Chemerin As Inflammatory Adipokines In Obese Patienmentioning

confidence: 99%

Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases)

et al. 2014

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The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research. The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases. We will discuss the main relevant evidences on the role of the AT on immune and inflammatory networks and the more recent evidences regarding the effects of obesity on the incidence and outcomes of the major autoimmune chronic inflammatory diseases.

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Plasma chemerin levels in rheumatoid arthritis are correlated with disease activity rather than obesity

Cited by 31 publications

References 9 publications

Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns

Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns

Chemerin: A comprehensive review elucidating the need for cardiovascular research

Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases)

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