Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein

Green, Gary M.; Levan, Van H.; Liddle, Roger A.

doi:10.1152/ajpgi.1986.251.1.g160-r

Cited by 9 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Green et al (1986), cholecystokinin is involved in the pancreatic protease adaptation to dietary protein in the rat. It is known that cholecystokinin is released in the intestine by food substances and their hydrolysis products.…”

Section: E C H a N I S M S O F P A N C R E A T I C A D A P T A T I O Nmentioning

confidence: 99%

Nutritional Regulation of Pancreatic and Biliary Secretions

1989

View full text Add to dashboard Cite

show abstract

Section: E C H a N I S M S O F P A N C R E A T I C A D A P T A T I O Nmentioning

confidence: 99%

Nutritional Regulation of Pancreatic and Biliary Secretions

1989

View full text Add to dashboard Cite

show abstract

“…For instance, milk-borne large proteins per se, which require digestion by pancreatic enzymes for intestinal absorption, might be involved in the developmental processes of pancreatic digestive functions in infants. In adults, dietary protein can act as a critical factor to stimulate the secretion and synthesis of pancreatic digestive enzymes at least in rats and perhaps in humans as well (13,14,34). Although there have been few studies on the physiological importance of large protein intake in infancy, there is a report that insufficient pancreatic digestive functions were observed in rats fed an amino acid diet with milk from dams during the weaning period (28).…”

mentioning

confidence: 99%

Large molecule protein feeding during the suckling period is required for the development of pancreatic digestive functions in rats

Kinouchi

Koyama

Harada

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Kinouchi T, Koyama S, Harada E, Yajima T. Large molecule protein feeding during the suckling period is required for the development of pancreatic digestive functions in rats. Am J Physiol Regul Integr Comp Physiol 303: R1268 -R1276, 2012. First published October 24, 2012 doi:10.1152/ajpregu.00064.2012.-We examined if large molecule protein feeding during the suckling period is prerequisite for the proper development of pancreatic digestive functions. Most amino acids in breast milk exist as the constituent of large proteins and not as oligopeptides or free amino acids. Accumulating evidence indicates the nutritional importance of large protein feeding for suckling infants; however, evidence on the physiological significance remains small. We thus artificially reared rat pups on a standard rat formula with milk protein or a formula with milk protein hydrolysate from 7 to 21 days of age, and thereafter, fed a standard solid diet until 42 days of age. Pancreas weight and the stock of pancreatic digestive enzymes in the hydrolysate-fed rats were significantly lower than those in the protein-fed rats during and also after the suckling period. Plasma insulin, a stimulator of amylase synthesis, was also significantly low in the hydrolysate-fed rats compared with the protein-fed rats. At 28 days of age, we evaluated the pancreatic secretory ability in response to dietary protein and cholecystokinin (CCK) by means of pancreatic duct cannulation. Pancreatic secretion stimulated by dietary protein in the hydrolysate-fed rats was significantly weaker than that in the protein-fed rats. No significant difference was observed in the increasing rate of pancreatic enzyme secretion in response to CCK between the two groups. These results suggest that the presence of large proteins in breast milk is significant for the development of pancreatic digestive functions and the outcomes could remain even later on in life. cholecystokinin; breast milk; protein hydrolysate formula; insulin MOST AMINO ACIDS in breast milk exist as the constituent of large molecule proteins. In human milk, for instance, about 95% of all amino acids constitute ␣-lactalbumin

show abstract

“…Rat studies of high protein feeding have most often used 5 or 10% protein as the control or low protein to maximize the effect of the high protein. In rats on 5% protein the body weight failed to increase over the 14 day experimental period and the pancreas weight decreased slightly (41).…”

Section: High Protein Dietmentioning

confidence: 92%

“…Switching from a 5-10% casein diet to one containing 70-75% casein caused an increase in pancreatic weight, protein and DNA content reaching a plateau in 7-14 days (40,41,91). This was accompanied by a transient increase in plasma CCK and the growth response could be partially blocked with a CCK antagonist (41,91). Protein is a primary stimulus for CCK release in the rat with casein being the most potent protein tested after trypsin inhibitor (71).…”

Section: High Protein Dietmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of Normal and Adaptive Pancreatic Growth

Williams¹

Pancreapedia: Exocrine Pancreas Knowledge Base

View full text Add to dashboard Cite

Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein

Cited by 9 publications

References 0 publications

Nutritional Regulation of Pancreatic and Biliary Secretions

Nutritional Regulation of Pancreatic and Biliary Secretions

Large molecule protein feeding during the suckling period is required for the development of pancreatic digestive functions in rats

Regulation of Normal and Adaptive Pancreatic Growth

Contact Info

Product

Resources

About