Plasma cholecystokinin concentrations in 3-day-old lambs: effect of the duration of fasting preceding a sucking bout

Nowak, Raymond; Orgeur, P.; Piketty, Vincent; Alster, Pawel; Andersson, Roland; Uvnäs‐Moberg, Kerstin

doi:10.1051/rnd:19970506

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…In addition, OT levels may also be elevated through the effect of endocrine factors such as the secretion of the gastrointestinal hormone CCK. This could well be the case in the lamb since CCK is released after suckling ( 30 , 33 ) and it is known, in the rat, that both CCK and gastric distension activate the oxytocinergic system in the hypothalamus, and trigger the release of OT in the plasma ( 71 , 72 ). Preliminary data from Experiment 2 demonstrate that OT concentrations also rise in the cerebrospinal fluid after bottle-feeding, and that the phenomenon is quite repeatable.…”

Section: Discussionmentioning

confidence: 99%

“…It appears that ingesting colostrum in the hours after birth is a key factor for the development of a preference for the mother ( 31 , 32 ). The neonatal suckling activity triggers the release of cholecystokinin (CCK) in the blood, a gastrointestinal hormone which activates vagal afferent fibres and the brain stem ( 33 , 34 ). Blocking the cholecystokininergic system with a specific antagonist that binds to peripheral receptors at birth prevents the development of a preference for the mother ( 35 – 37 ).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Suckling, Oxytocin, and Early Infant Attachment to the Mother

et al. 2021

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The neuropeptide oxytocin (OT) promotes maternal care and social affiliation in adults but its importance in infant attachment still remains unknown. True animal models of infant attachment are extremely rare, and the sheep (in complement to non-human primates) is one of the few that provides the opportunity to investigate its neuroendocrinological basis. In the lamb, access to the udder has strong rewarding properties for the establishment of a preferential relationship with the mother. Therefore, the present study explored the possible involvement of OT through its release during close social contacts with the mother. The first experiment revealed that lambs having free access to the udder from birth onward developed, by 12 h of age, a clear preference for their mothers over another maternal ewe. Delaying access to the udder for six, four or even only 2 h starting at birth, by covering the ewe’s udder, resulted in the lack of such a preference without affecting general activity. These effects persisted in most cases at 24 h but by 72 h of age a bond with the mother was clearly expressed. Experiment two showed that social interactions with the mother were followed by a release of OT in the plasma when lambs had the possibility to suckle. Non-nutritive interactions were without effects. Preliminary data on two subjects suggested that OT might also increase in the cerebrospinal fluid after suckling. Finally, in the third experiment, oral administration of a non-peptide OT receptor antagonist (L-368-899, Merck) over the first 4 h after birth led to decreased exploration of the mother’s body compared to lambs receiving saline, and impaired the expression of a preference for the mother at 24 h. The effects were no longer observed at 48 h. Our findings demonstrate that both delayed access to the mother’s udder and OT receptor antagonist alter the onset of mother preference in newborn lambs. This suggests that central OT facilitates the development of filial attachment through its release during suckling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neonatal Suckling, Oxytocin, and Early Infant Attachment to the Mother

et al. 2021

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“…Plasma concentrations of ghrelin in fasting humans, rats and ruminants are higher than non-fasting humans and animals (Kojima & Kangawa 2005;Wertz-Lutz et al 2006). In addition, plasma CCK levels of fasting rats (Kanayama & Liddle 1991), 3-day-old lambs (Nowak et al 1997) and humans (Ohgo et al 1988) were low. Therefore, basal plasma ghrelin and CCK levels between fasting conditions and non-fasting conditions are different.…”

Section: Introductionmentioning

confidence: 97%

“…2006). In addition, plasma CCK levels of fasting rats (Kanayama & Liddle 1991), 3‐day‐old lambs (Nowak et al . 1997) and humans (Ohgo et al .…”

Section: Introductionmentioning

confidence: 99%

Sulfated cholecystokinin‐8 increases ghrelin secretion but does not affect oxyntomodulin in Holstein steers

Yannaing

ThidarMyint

Zhao

et al. 2012

Animal Science Journal

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The effect of appetite regulatory hormone cholecystokinin (CCK) on the secretions of oxyntomodulin (OXM) and ghrelin, and the effect of ghrelin on the secretions of CCK and OXM were studied in ruminants. Eight Holstein steers, 7 months old, 243 ± 7 kg body weight (BW), were arranged in an incomplete Latin square design (8 animals × 4 treatments × 4 days of sampling). Steers were intravenously injected with 10 µg of sulfated CCK-8/kg BW, 20 µg of acyl ghrelin/kg BW, 100 µg of des-acyl ghrelin/kg BW or vehicle. Blood samples were collected from -60 min to 120 min relative to time of injection. Plasma concentrations of ghrelin, sulfated CCK and OXM were measured by double-antibody radioimmunoassay. Plasma acyl ghrelin was increased to peak level (428.3 ± 6 pg/mL) at 60 min after injection of CCK compared with pre-injected levels (203.3 ± 1 pg/mL). These results showed for the first time, that intravenous bolus injection of CCK increased ghrelin secretion in ruminants. In contrast, injection of ghrelin did not change CCK secretion. Administration of ghrelin or CCK has no effect on plasma OXM concentrations. In conclusion, our results show that administration of CCK increased ghrelin secretion but did not affect OXM release in ruminants. Ghrelin did not affect the secretions of CCK and OXM.

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“…By the age of 24 hr, lambs show a strong preference for their mothers over alien ewes (Nowak, 1990), an ability depending mainly on experiencing the first suckling interactions, in addition to visual and auditory cues (Nowak, 1991; Nowak, Murphy, et al, 1997). Nowak, Orgeur, et al (1997) showed that suckling was followed by a significant increase of plasma CCK levels over the 20–50-min period assessed postsuckling. Furthermore, only lambs whose CCK plasma levels increased in the first 6 postnatal hours displayed a preference for their mothers at 24 hr (Nowak, Murphy, et al, 1997).…”

mentioning

confidence: 96%

Mother-Infant Interactions in Rats Lacking CCKA Receptors.

Lavi-Avnon¹,

Malkesman²,

Hurwitz³

et al. 2004

Behavioral Neuroscience

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Mediation of mother-infant interactions by the brain-gut peptide cholecystokinin (CCK) was examined by observing behavior of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which lack functional CCKA receptors because of a genetic abnormality. OLETF (n = 10) and control (Long-Evans Tokushima Otsuka [LETO] n = 10) dams interacted with 1 pup of each line on Postpartum Days 6-9. OLETF pups received more body and anogenital licking and emitted substantially more ultrasonic vocalizations than LETO pups. OLETF dams carried pups less frequently and showed a nursing position more frequently than LETO dams. No significant Pup X Dam Line interactions or line differences in dams' activity were detected. The results provide convergent validity to previous pharmacological studies implicating CCK mediation of both infant and maternal behavior.

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Plasma cholecystokinin concentrations in 3-day-old lambs: effect of the duration of fasting preceding a sucking bout

Cited by 10 publications

References 21 publications

Neonatal Suckling, Oxytocin, and Early Infant Attachment to the Mother

Neonatal Suckling, Oxytocin, and Early Infant Attachment to the Mother

Sulfated cholecystokinin‐8 increases ghrelin secretion but does not affect oxyntomodulin in Holstein steers

Mother-Infant Interactions in Rats Lacking CCKA Receptors.

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