Plasma cholesterol and the plasma copper/zinc ratio in young children

Shapcott, Dennis; Vobecký, J; Demers, P-P

doi:10.1016/0048-9697(85)90021-x

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…In most studies including adult patients, no relationship between blood zinc and cholesterol has been found [26][27][28][29]. However, patients with marked hypercholesterolemia (8.92 ± 0.92 mmol/1 cholesterol) have been reported to have low zinc levels, a result not found in patients with milder hypercholesterolemia (7.18 ± 0.35 mmol/1) [30].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

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Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and beta-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, beta-carotene, and copper, but had lower plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. The study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis.

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Section: Discussionmentioning

confidence: 99%

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

View full text Add to dashboard Cite

show abstract

“…Laitinen and colleagues observed lower serum copper levels were associated with higher levels of cholesterol and triglyceride in adolescents [42]. However there is some evidence for there being no relationship between serum zinc and copper concentrations in hyperlipidemia; although zinc and copper supplementation was reported to improve some aspects of lipid metabolism [43]. An increased serum copper was observed in patients with severe coronary heart disease although it may be a consequence rather than cause [44].…”

Section: Trace Elements and Lipid Metabolismmentioning

confidence: 99%