Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology

Inazu, Akihiro

doi:10.1016/b978-0-12-382171-3.10003-8

Cited by 3 publications

(2 citation statements)

References 124 publications

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“…regulation of cholesterol esterification" refers to cholesterol esterification, a critical step in reverse cholesterol transport, the process in which excess cholesterol is sent to the liver to be removed from the body [15,25]. Furthermore, Cholesteryl Ester Transfer Protein (CETP) is a key enzyme involved in this process and is highly expressed in liver cells, and variants of CETP are associated with increased risk of atherosclerosis [31,15]. The fifth most significant term, "lipoprotein remodeling" is part of the two aforementioned processes.…”

Section: Analysis Of Key Genesmentioning

confidence: 99%

Supervised Adversarial Alignment of Single-Cell RNA-seq Data

Wang²,

Alavi³

et al. 2020

Preprint

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Dimensionality reduction is an important first step in the analysis of single cell RNA-seq (scRNA-seq) data. In addition to enabling the visualization of the profiled cells, such representations are used by many downstream analyses methods ranging from pseudo-time reconstruction to clustering to alignment of scRNA-seq data from different experiments, platforms, and labs. Both supervised and unsupervised methods have been proposed to reduce the dimension of scRNA-seq. However, all methods to date are sensitive to batch effects. When batches correlate with cell types, as is often the case, their impact can lead to representations that are batch rather than cell type specific. To overcome this we developed a domain adversarial neural network model for learning a reduced dimension representation of scRNA-seq data. The adversarial model tries to simultaneously optimize two objectives. The first is the accuracy of cell type assignment and the second is the inability to distinguish the batch (domain). We tested the method by using the resulting representation to align several different datasets. As we show, by overcoming batch effects our method was able to correctly separate cell types, improving on several prior methods suggested for this task. Analysis of the top features used by the network indicates that by taking the batch impact into account, the reduced representation is much better able to focus on key genes for each cell type.

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Section: Analysis Of Key Genesmentioning

confidence: 99%

Supervised Adversarial Alignment of Single-Cell RNA-seq Data

Wang²,

Alavi³

et al. 2020

Preprint

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“…Serum TC and triglyceride (TG) were determined by enzymatic methods. Cholestest®N HDL (Sekisui Medical, Tokyo, Japan) was used for measurement of HDL-C, and Friedewald calculation was used for LDL-C estimation because a direct method for LDL-C has not been validated in CETP deficiency [7,11]. Serum apolipoprotein concentrations were determined by immunoassay.…”

Section: Biochemical Analysesmentioning

confidence: 99%

Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects

Ohtani

Inazu

Noji

et al. 2012

Clinica Chimica Acta

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Background: The half of hyperalphalipoproteinemia (HALP) in Japan is caused by CETP gene mutations. Other than two prevalent mutations (D442G and Intron 14 splicing donor site +1 G>A), some rare CETP mutations are found in Japanese HALP subjects.Methods: CETP gene analysis of genomic DNA from subjects was performed by restriction fragment length polymorphism (RFLP) and sequencing analysis. Mutations which were suspected to cause a splicing defect or a protein secretion defect were investigated in COS-1 cells transfected with a CETP minigene construct or a cDNA expression vector.Results: Each of three subjects was identified as a carrier of CETP gene mutation of a compound heterozygote of c.653_654delGGinsAAAC and Intron 14 splicing donor site +1 G>A, a heterozygote of c.658G>A or a homozygote of L261R. The c.658G>A mutation was located at the last nucleotide of exon 7, and it was confirmed to cause splicing abnormality revealed by the CETP minigene analysis. The L261R CETP was not secreted to conditioned media of the cells.Conclusions: Three novel CETP gene mutations are responsible for HALP by CETP deficiency. It is predicted that there are more rare CETP gene mutations in Japanese, and these multiple rare mutations alone or a combination with each of prevalent mutations responsible for mild-to-moderate or marked HALP, respectively.3

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Supervised Adversarial Alignment of Single-Cell RNA-seq Data

Wang

Alavi

et al. 2020

Lecture Notes in Computer Science

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Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology

Cited by 3 publications

References 124 publications

Supervised Adversarial Alignment of Single-Cell RNA-seq Data

Supervised Adversarial Alignment of Single-Cell RNA-seq Data

Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects

Supervised Adversarial Alignment of Single-Cell RNA-seq Data

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