1980
DOI: 10.1111/j.1365-2044.1980.tb03800.x
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Plasma cholinesterase variants and the anaesthetist

Abstract: SummaryBiochemical properties of plasma cholinesterase of significance to the anaesthetisr are resiewed.The role of the genetic ciariants of the enzyme in suxamethonium sensiticity and hyperthermia are ~liscirssed with emphasis on the pregnant patient. Alteredgene frequencies of the enzyme trariants in some nieritul disorders is connnented upon.

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Cited by 227 publications
(96 citation statements)
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“…Another important role of BChE activity is as a marker to predict the prognosis of diseases. When the activity of the enzyme is low, subjects are at high risk of death (Whittaker, 1980). This idea is reinforced by the fact that in our study no rat died due to infection up to day 30 p.i.…”
Section: Discussionsupporting
confidence: 52%
“…Another important role of BChE activity is as a marker to predict the prognosis of diseases. When the activity of the enzyme is low, subjects are at high risk of death (Whittaker, 1980). This idea is reinforced by the fact that in our study no rat died due to infection up to day 30 p.i.…”
Section: Discussionsupporting
confidence: 52%
“…19 We encountered five patients, occurring in all groups. Their ChE concentration ranged from 180 to 1700 u. L -1 and flaeir dibucaine numbers from 8 to 56.9%.…”
Section: Discussionmentioning
confidence: 99%
“…The homozygotes and double heterozygote in the various combinations involving E1 a, E1 f, and E1S (6 in all) invariably exhibit moderate to severe SCC hypersensitivity. Other rare genes designated as EI~, E1 k, C1 d, E1 ale have also been reported in the heterozygous condition (Whittaker, 1980). The first instance of PsChE anomaly in Japan was discovered by us in 1967 in a 62 yr-old male patient with hypertension and encephalomalacia (Shibata et al, 1967).…”
Section: Genetics Of Psche and Case Reportsmentioning
confidence: 99%
“…Many competitive and denaturing agents have been introduced as suitable inhibitors for PsChE phenotyping (Whittaker, 1980), such as dibucaine (D), sodium fluoride (F), sodium chloride (C1), butanol (Alc), pancronium (P), scoline (= suxamethonium) (S), urea (U), sodium bromide (Br), Rosche's agent of and propranolol (Pr). Of the inhibitors aforelisted, the first two substances (D, F) are the main subtyping agents based on the structural aberrancy of the PsChE molecule, since they interact with the substrate at the anionic and ester sites of the enzyme molecule, respectively.…”
mentioning
confidence: 99%