Plasma circulating fibrinogen stability and moderate beer consumption

Gorinstein, Shela; Caspi, Abraham; Zemser, Marina; Libman, Imanuel; Goshev, Ivan; Trakhtenberg, Simon

doi:10.1016/j.jnutbio.2003.09.002

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…A series of studies using animal models and human being have shown that beer provides plasma with significant protection from oxidative stress and improves lipid metabolism, and suppresses atherosclerosis (Gorinstein et al 1997(Gorinstein et al , 2003Cepicka and Karabin 2002;Vinson et al 2003;Kondo 2004).…”

Section: Discussionmentioning

confidence: 99%

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Bioactivity of beer and its influence on human metabolism

Gorinstein

Caspi

Libman

et al. 2007

International Journal of Food Sciences and Nutrition

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Extracted total phenols, flavanols and flavonoids were measured in beer samples and their quality as antioxidants was measured by two modified antioxidant methods: the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS * +) and the beta-carotene-linoleate model system (beta-carotene). It was found that the antioxidant potential of beer was well correlated with flavanols and flavonoids and was slightly lower with total polyphenols (R2 values from 0.8203 to 0.9393). Forty-two male non drinkers, hypercholesterolaemic volunteers ages 43-71 after coronary bypass surgery, were randomly divided into experimental (EG) and control (CG) groups, each of 21 participants. The antiatherosclerotic diet of the EG group was supplemented for 30 consecutive days with 330 ml beer per day. Could short-term beer consumption affect not only the risk factors of coronary atherosclerosis, but also the markers of this process: plasma albumin and its antioxidant activity? For this goal, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, plasma albumin and fibrinogen, and the antioxidant activity were determined. After the trial a significant improvement in the plasma lipid levels, and an increase in the plasma antioxidant and anticoagulant activities in patients of the EG group was registered. A parallel increase in the plasma albumin concentration and its antioxidant activity was observed. In conclusion, short-term beer consumption on the basis of the bioactivity of the beverage positively affects plasma lipid levels, plasma antioxidant and anticoagulant activities. The increase in the plasma albumin concentration and its antioxidant activity could be the markers of atherosclerosis status.

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Section: Discussionmentioning

confidence: 99%

“…Plasma albumin was precipitated with 2 M ammonium sulfate, fibrinogen with methanol, then purified by sequential DEAE anion-exchange chromatography, dialysed against water for 72 h, and lyophilized (Gorinstein et al 2003).…”

Section: Laboratory Methodsmentioning

confidence: 99%

Bioactivity of beer and its influence on human metabolism

Gorinstein

Caspi

Libman

et al. 2007

International Journal of Food Sciences and Nutrition

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“…44 Fibrinogen has a significant role in atherogenesis and thrombogenesis, fibrinolysis, and inflammation. 45,46 Besides the decrease in the plasma levels of fibrinogen, it seems that alcohol also affects the stability of the fibrinogen, leading to a loosening of its structure. 45 Adiponectin, which levels also increase with the consumption of alcohol, 20 has insulin-sensitizing, anti-inflammatory, antithrombotic, and antiatherogenic effects.…”

Section: Potential Mechanisms For the Observed Associationmentioning

confidence: 99%

“…45,46 Besides the decrease in the plasma levels of fibrinogen, it seems that alcohol also affects the stability of the fibrinogen, leading to a loosening of its structure. 45 Adiponectin, which levels also increase with the consumption of alcohol, 20 has insulin-sensitizing, anti-inflammatory, antithrombotic, and antiatherogenic effects. 47 Low levels of adiponectin were associated with increased valvular inflammation and neovascularization and faster evolution of stenosis in individuals with calcific aortic stenosis.…”

Section: Potential Mechanisms For the Observed Associationmentioning

confidence: 99%

Light to Moderate Alcohol Consumption Is Associated With Lower Risk of Aortic Valve Sclerosis

Markus

Lieb

Stritzke

et al. 2015

ATVB

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Objective-In developed countries, sclerotic and calcific degeneration of the aortic valve is a common disorder showing pathophysiologic similarities with atherothrombotic coronary disease. Light to moderate alcohol consumption has been associated with a lower risk for atherothrombotic coronary disease and mortality. Whether alcohol consumption affects the development of aortic valve sclerosis (AVS) is not well known. In the present study, we aim to analyze the crosssectional association between average daily alcohol consumption and AVS in the general population. Approach and Results-We analyzed cross-sectional data from 2022 men and women, aged 45 to 81 years, from the population-based Study of Health in Pomerania. We used a computer-assisted interview that included beverage-specific questions about quantity and frequency of alcohol over the last 30 days to calculate the average quantity of alcohol consumption (in grams of ethanol per day). AVS was ascertained by echocardiography. The prevalence of AVS was 32.3%. Average daily alcohol intake displayed a J-type relation with AVS (fully adjusted P value: 0.005). Compared with individuals with an average consumption of 10 g of alcohol per day, multivariable-adjusted odds ratios were 1.60 (95% confidence interval, 1.19-2.14) among current abstainers and 1.56 (95% confidence interval, 1.01-2.41) among individuals with an average consumption of 60 g per day. Conclusions-Our

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“…184These values were previously determined via Circular Dichroism (CD) and ATR-FTIR 185 spectroscopy (Azpiazu and Chapman, 1992;Gorinstein et al, 2003). According to already 186 published data the water content was proven to be a major factor influencing secondary 187structure of proteins.…”

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confidence: 99%