Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn’s disease: preliminary report

Diamanti, Antonella; Knafelz, D.; Panetta, Fabio; Bracci, F.; Gambarara, M.; Papadatou, B.; Daniele, Antonella; Goffredo, Bianca Maria; Pezzi, Simona; Torre, Giuliano

doi:10.1007/s00384-011-1255-z

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…Citrulline levels were compared between Crohn’s disease patients and controls in two studies 40 , 41 . The random‐effects model showed that citrulline levels in patients vs controls was decreased by –9.7 µmol/l (95% CI (–12.6, –6.7)) (SMD –1.19, 95% CI (–1.63, –0.75)); there was no heterogeneity (MD: I 2 = 0%, p = 0.90; SMD: I 2 = 0%, p = 0.99) (Figure 5(a) ).…”

Section: Resultsmentioning

confidence: 99%

Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta‐analysis

2018

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Background: Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective: The objective of this article is to examine the evidence of plasma citrulline as a marker of intestinal function and absorption in various clinical settings. Methods: Studies were examined for p values, means and standard deviations, correlation coefficients or other metrics depicting the association of citrulline with intestinal function. A random effects model was used to produce a pooled estimate. A hierarchical summary receiver operating curve model was fitted for diagnostic accuracy measures. Results: Citrulline levels are correlated strongly with small bowel length in short bowel syndrome patients (r ¼ 0.67). Citrulline is strongly negatively correlated (r ¼ -0.56) with intestinal disease severity with regards to enteropathies (coeliac disease, tropical enteropathy, Crohn's disease, mucositis, acute rejection in intestinal transplantation). Citrulline cut-off levels have an overall sensitivity and specificity of 80% and 84% respectively. Citrulline levels in untreated coeliac patients compared to controls were reduced by 10 mmol/l. Citrulline levels increase with gluten-free diet and with improvement of enteropathy. Citrulline is decreased in critical illness and sepsis. Conclusion: These findings allow us to advocate quite reasonably that citrulline is a marker of acute and chronic intestinal insufficiency.

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Section: Resultsmentioning

confidence: 99%

Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta‐analysis

2018

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“…To our knowledge, this is the first study showing that plasma valine is negatively associated with fecal calprotectin. This is an intriguing result, since previous research has shown that another plasma amino acid, namely citrulline, did not correlate with fecal calprotectin or with CRP in pediatric and adolescent IBD, known as direct markers of inflammation [ 21 ]. Herein, the negative association of valine with fecal calprotectin was not accompanied by an association of total or individual BCAAs with IBDQ or with PMS or CRP that are widely used in clinical practice in order to assess and monitor disease activity.…”

Section: Discussionmentioning

confidence: 91%

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

et al. 2020

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Branched-chain amino acids (BCAAs) are involved in immune system’s metabolic pathways and play fundamental role in gut health. Our aim was to assess BCAA plasma levels in patients with ulcerative colitis (UC) and associations of plasma BCAAs with disease-related parameters. This was a case-control study in adult patients with UC and BMI-matched controls. A total of 150 volunteers were screened between May 2016 and June 2017; 43 patients and 34 healthy controls were enrolled. Medical and dietary history (3 × 24 h recalls, MedDiet score), anthropometric measurements, blood and fecal samples were collected. We measured BCAAs in plasma with gas chromatography-mass spectrometry. In patients, fecal calprotectin, lactoferrin, lysozyme and defensin were quantified. Dietary pattern was similar in patients and controls. Plasma-free BCAA profiles did not differ between groups. Regression analysis showed that i) valine was inversely associated with calprotectin (p = 0.007) and ii) isoleucine with age (p = 0.031), after adjusting for age, sex, PMS and smoking. Leucine was negatively associated with age (p = 0.015) after adjusting for age, sex and PMS, but this association vanished when smoking was introduced. No correlation was observed between total BCAAs with any of the parameters. Plasma-free valine is negatively associated with calprotectin in patients with UC.

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“…This study also suggests host-interaction pathways (amino acids) related to the pathogenesis of peptic ulcer in H. pylori infected patients. Interestingly, in Crohn’s disease, a gastrointestinal inflammatory disease, serum citrulline was found to be inversely correlated with each other [16]. The presence of amino acids that correspond to the urea cycle could reflect the presence of a urea cycle and a highly active urease in H. pylori .…”

Section: Resultsmentioning

confidence: 99%

Diagnostics for Statistical Variable Selection Methods for Prediction of Peptic Ulcer Disease in Helicobacter pylori Infection

Brasier

Kurosky

et al. 2014

J Proteomics Bioinform

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BackgroundThe development of accurate classification models depends upon the methods used to identify the most relevant variables. The aim of this article is to evaluate variable selection methods to identify important variables in predicting a binary response using nonlinear statistical models. Our goals in model selection include producing non-overfitting stable models that are interpretable, that generate accurate predictions and have minimum bias. This work was motivated by data on clinical and laboratory features of Helicobacter pylori infections obtained from 60 individuals enrolled in a prospective observational study.ResultsWe carried out a comprehensive performance comparison of several nonlinear classification models over the H. pylori data set. We compared variable selection results by Multivariate Adaptive Regression Splines (MARS), Logistic Regression with regularization, Generalized Additive Models (GAMs) and Bayesian Variable Selection in GAMs. We found that the MARS model approach has the highest predictive power because the nonlinearity assumptions of candidate predictors are strongly satisfied, a finding demonstrated via deviance chi-square testing procedures in GAMs.ConclusionsOur results suggest that the physiological free amino acids citrulline, histidine, lysine and arginine are the major features for predicting H. pylori peptic ulcer disease on the basis of amino acid profiling.

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Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn’s disease: preliminary report

Cited by 12 publications

References 25 publications

Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta‐analysis

Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta‐analysis

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

Diagnostics for Statistical Variable Selection Methods for Prediction of Peptic Ulcer Disease in Helicobacter pylori Infection

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