Plasma citrulline levels are increased in patients with multiple sclerosis

Vyver, Maxime Vande; Beelen, Roel; Keyser, Jacques De; Nagels, Guy; Binst, Anne-Marie Van; Verborgh, Christiaan; D’haeseleer, Miguel

doi:10.1016/j.jns.2018.02.025

Cited by 8 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…L-citrulline alleviated the gastric mucosal lesions and inhibited malondialdehyde (MDA) and myeloperoxidase (MPO) activity during ischemia-reperfusion in rats, thus eliciting protective effects on gastric mucus synthesis and secretion [113]. Further, plasma citrulline levels are elevated in multiple sclerosis [138]. Thus, citrulline is a validated marker of intestinal barrier functions and disorders [13,37].…”

Section: Potential Combinatory Roles For Citrulline and Quercetin In Gastrointestinal Health Of Animalsmentioning

confidence: 99%

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.

show abstract

Section: Potential Combinatory Roles For Citrulline and Quercetin In Gastrointestinal Health Of Animalsmentioning

confidence: 99%

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…NFL concentrations were marginally increased in ESRD patients, although no significant associations could be established with cognitive functions (Hou et al, 2021). Two other measurable neuronal damage markers that were not examined in ESRD are myelin basic protein (MBP), the main protein of the myelin sheath that plays a key role in maintaining the stability of the myelin sheath (Vyver et al, 2018), and ionized calcium-binding adaptor molecule-1 (IBA1), a microglia/macrophage-specific calcium-binding protein, which is necessary for the phagocytosis of activated microglia (Sasaki et al, 2001, Lafrenaye et al, 2020.…”

Section: Introductionmentioning

confidence: 99%