Plasma-coagulation hemostasis in physically active subjects during adaptation to physical exercise

Tikhomirova, S. V.; Vikulov, A. D.; Baranov, A.A.; Osetrov, I. A.

doi:10.1134/s0362119707060114

Cited by 4 publications

(3 citation statements)

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“…Even if their mean values fell within the physiologic range of horses, these data suggest a pro-coagulative status. These results are in agreement with data obtained in humans [ 12 ] and in Thoroughbreds [ 3 , 7 ]. Nevertheless, differently from previous studies in Thoroughbreds, we found that the greatest variations in clotting parameters [ 7 ] during long-term training were reached at T30.…”

Section: Discussionsupporting

confidence: 93%

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Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds

Miglio

Falcinelli

Mezzasoma

et al. 2021

Animals

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Training has a strong effect on the physiology of hematological parameters and blood coagulation, both in humans and in horses. Several blood changes have been reported after exercise in horses but available data differ. We aimed to investigate modifications in complete blood count and some hemostatic parameters induced by the first training period in young untrained Thoroughbred racehorses to detect a possible labile blood coagulability in racehorses. Twenty-nine untrained 2-year-old Thoroughbreds were followed during their incremental 4-month sprint exercise schedule. Blood collection was performed once a month, five times (T-30, T0, T30, T60 and T90), before and during the training period for measurement of complete blood count (CBC) and blood clotting parameters (prothrombin time—PT, activated partial prothrombin time—APTT, thrombin clotting time—TCT, fibrinogen—Fb, thrombin–antithrombin complex—TAT). Differences among the time points for each parameter were analyzed (ANOVA, Kruskal–Wallis one-way analysis of variance, p < 0.05). In Thoroughbreds, the first long-term exercise workout period was found to induce a statistical increase in red blood cell indexes and lymphocytes, eosinophils and platelet counts, as well as a hypercoagulability state evident at 30 days of training, which returned to basal levels after 90 days. Regular physical exercise seems to blunt the negative effects of acute efforts on hematological and clotting parameters, an effect that may be attributed to the training condition.

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Section: Discussionsupporting

confidence: 93%

“…Training has a large effect on the physiology of blood coagulation both in humans and in horses [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Available data reporting hemostatic changes after exercise in horses are relatively scarce and not unequivocal.…”

Section: Introductionmentioning

confidence: 99%

Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds

Miglio

Falcinelli

Mezzasoma

et al. 2021

Animals

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“…53 A standardized cycle ergometer test in active young men induced a significant increase in FVIII activity, occurring with a significant shortening of the APTT; during recovery, the increase in FVIII activity after exercise persisted up to 6 hours. 54 Although athletes practicing cyclic sports display a decrease in the activity of natural anticoagulants (namely protein C and antithrombin), 55 it has also been reported that exhaustive running in subjects with resistance to activated protein C did not induce any abnormal hemostatic or fibrinolytic response, suggesting that vigorous exercise would not imply an increased risk of thrombosis in young carriers of this thrombophilic mutation. 56 Moreover, a slight but significant decrease was found in the extrinsic pathway inhibitor activity after a short-term run (1.7 km).…”

Section: Influence Of Physical Exercise On Secondary Hemostasismentioning

confidence: 99%

Biological Influence of Physical Exercise on Hemostasis

Lippi

Maffulli²

2009

Semin Thromb Hemost

126

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Some of the benefits of physical activity may result from effects on hemostasis. However, the increased burden of cardiovascular complications and sudden death occurring during and immediately after exercise prompts investigation to elucidate the biological relationship between physical exercise and hemostatic function. Although both the hemostatic and fibrinolytic systems are strongly influenced by physical exercise, the outcomes of available studies to date are biased by several confounding variables, including the subjects investigated, the type, intensity, and duration of the exercise, and the methods used for hemostatic evaluation. Considering these variables and attempting to synthesize the available data, it seems reasonable to conclude that the biological changes induced by physical activity are consistent with a mechanistic model where acute and strenuous exercise is associated with a transient hypercoagulability state, particularly in untrained individuals. This is mostly due to increased thrombin generation, platelet hyperreactivity, and increased activity of several coagulation factors, especially factor VIII and von Willebrand factor. Contextually, increased fibrinolytic activity has been frequently reported after exercise. Such changes, however, seem completely reversible, as trained subjects at rest show a partial exhaustion of platelet function in addition to values of several parameters of both the coagulation and fibrinolytic systems that are globally comparable with or even lower than those observed in the sedentary population. These adaptive changes might be beneficial in the long term, offering some protection against the risk of thrombosis and adverse cardiovascular events in physically active individuals.

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Changes in blood coagulation induced by exercise training in young athletic horses

Assenza

Tosto

Casella

et al. 2013

Research in Veterinary Science

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Plasma-coagulation hemostasis in physically active subjects during adaptation to physical exercise

Cited by 4 publications

References 1 publication

Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds

Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds

Biological Influence of Physical Exercise on Hemostasis

Changes in blood coagulation induced by exercise training in young athletic horses

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