Plasma concentration of 14 perfluoroalkyl acids (PFAAs) among children from seven cities in Guangdong, China

Zhang, Ruijia; Ye, Jufeng; Wei, Qiujing; Li, Minjie; Xu, Kaihui; Li, Zihuan; Lin, Wenting; Liu, Pei-Shan; Chen, Ruopei; Ma, Aijin; Zhou, Zhifeng

doi:10.1016/j.scitotenv.2017.10.167

Cited by 17 publications

(3 citation statements)

References 40 publications

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“…Children at early ages are exposed to PFAS via various pathways, including breastfeeding, ingestion of contaminated food, water, dust, and soil, and hand-to-mouth contact with indoor surfaces. − Because of their relatively high food and dust ingestion rates per body weight and age-specific behaviors, such as frequent hand-to-mouth activity and playing close to the ground, young children may experience higher PFAS exposure than adults. ,, Many studies that quantified PFAS in the serum or plasma of children aged 1 to 5 years showed that PFAS were detected in this vulnerable population even after phase-out efforts. ,,− Three studies examining temporal trends of PFAS body burden in children aged 0 to 12 years have consistently observed decreases in concentrations of two major PFAS, PFOS and PFOA, since the early 2000s. ,, However, these studies showed mixed temporal trends for PFHxS and perfluorononanoic acid (PFNA) and did not investigate longer- or shorter-alkyl-chain PFAS.…”

Section: Introductionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations

Oh,

Shin,

Kannan

et al. 2024

Environ. Sci. Technol.

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Young children may experience higher per- and polyfluoroalkyl substances (PFAS) exposure than adults due to breastfeeding, higher dust ingestion rates, and frequent hand-to-mouth activities. We explored temporal trends and determinants of child serum PFAS concentrations and their correlations with paired maternal PFAS concentrations. From 2009 to 2017, we collected one blood sample from each of 541 children aged 2–5 years participating in the Childhood Autism Risks from Genetics and Environment (CHARGE) study and quantified 14 PFAS in serum. For nine frequently detected PFAS (>65% of samples), we performed multiple regression adjusting for potential determinants to estimate mean percent concentration changes. For a subset of 327 children, we also quantified nine PFAS in their mother’s serum collected at the same visit and computed Spearman correlation coefficients (r sp) between maternal and child PFAS concentrations. During 2009–2017, child serum concentrations of all nine PFAS decreased by 6–25% annually. Several PFAS concentrations were higher among non-Hispanic white children and those with highly educated parents. Most maternal and child PFAS concentrations were moderately correlated (r sp = 0.13–0.39), with a strong correlation for N-methyl perfluorooctane sulfonamido acetic acid (r sp = 0.68). Breastfeeding duration appeared to contribute to higher child and lower maternal PFAS concentrations, resulting in relatively weak correlations between maternal and child PFAS concentrations for samples collected in early childhood. Considering that more than half of our study children had neurodevelopmental concerns, the generalizability of our findings might be limited.

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Section: Introductionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations

Oh,

Shin,

Kannan

et al. 2024

Environ. Sci. Technol.

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“…Infants and young children are exposed to PFAS through ingestion of breast milk, contaminated food and water, and house dust and soil (Fromme et al 2010;Fromme et al 2009;Kärrman et al 2007;Trudel et al 2008;Winkens et al 2017;Wu and Kannan 2019). Due to their widespread exposure and persistence, several long-chain PFAS, including perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexane-1-sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), are frequently detected in the blood of children aged from 0 to 17 years (Duffek et al 2020;Gump et al 2011;Koponen et al 2018;Schecter et al 2012;Ye et al 2018;Zhang et al 2018b).…”

Section: Introductionmentioning

confidence: 99%

Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study

Shin

Schmidt

et al. 2022

ISEE Conference Abstracts

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Author's contributions JO, HS, IH, and DHB conceived the study, and IH and DHB oversaw its coordination. JO conducted data analyses and drafted the initial manuscript. HS, RJS, JBS, IH, and DHB helped oversee the study. KK quantified PFAS in child serum samples. SAB conducted preliminary data analyses. All authors reviewed and approved the final manuscript. Ethics approval and consent to participateThe CHARGE study protocol and this study were approved by the institutional review boards (IRB) for the State of California and the University of California-Davis (UC-Davis). Participants provided written informed consent before collection of any data.

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“…Therefore, the most hazardous POPs were included in the initial list of the Stockholm Convention, to reduce their emissions or prohibit their production and application in order to alleviate the environmental and body burden (Lee et al., 2006). Recently, several compounds extensively used for different purposes have been classified as hazardous POPs and added to the Stockholm Convention, these include pentachlorophenol (PCP) and its salts (Martins et al., 2018), and perfluorochemicals (Zhang et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and dietary exposure assessment of pentachlorophenol in livestock, poultry, and aquatic foods marketed in Guangdong Province, China: Based on food monitoring data from 2015 to 2018

Zhou

Lin

et al. 2021

Journal of Food Science

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As a persistent organic pollutant, pentachlorophenol (PCP) has serious impacts on human health. However, its presence in animal source food products sold in the Guangdong Province (GD) of China, and the resultant dietary exposure have not been elucidated. To address this gap, 3,100 samples from seven food categories, including beef, pork, mutton, offals, broilers, hen eggs, and farmed freshwater fish, marketed throughout four geographical regions of GD, were collected from 2015 to 2018. Gas chromatography coupled with mass spectrometry was employed to detect PCP levels in these food matrices. PCP was found in all food categories, but the average contamination levels were low, ranging from 0.40 µg/kg wet weight (ww) (hen eggs) to 5.85 µg/kg ww (offals). However, higher concentrations of PCP were detected (P < 0.05) in animal source food from the North region. Additionally, a temporal declining trend was observed in this four‐year consecutive survey. The estimated human dietary exposure of PCP to population groups, including the general population and subgroups (male and female, children, and adults), was found to be far below the permissible daily intake (3 µg/kg body weight). Therefore, the health impacts of PCP should be correspondingly low for local residents, based on current toxicological knowledge. Regional exposure patterns varied due to different extents of contamination in the four areas, and pork, broilers, and freshwater fish were the major sources of dietary PCP exposure. Practical Application As a persistent organic pollutant, pentachlorophenol (PCP) has serious impacts on human health. However, its presence in animal source food products sold in Guangdong Province of China, and the resultant dietary exposure have not been elucidated. In this study, we conducted an in‐depth investigation on the occurrence of PCP in major foodstuff categories, including beef, pork, mutton, broilers, offals, hen eggs, and farmed freshwater fish, marketed in all 21 prefecture‐level divisions of Guangdong Province, in order to provide integral insights for regulatory authorities.

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Plasma concentration of 14 perfluoroalkyl acids (PFAAs) among children from seven cities in Guangdong, China

Cited by 17 publications

References 40 publications

Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations

Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations

Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study

Occurrence and dietary exposure assessment of pentachlorophenol in livestock, poultry, and aquatic foods marketed in Guangdong Province, China: Based on food monitoring data from 2015 to 2018

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