Plasma concentration of gentamicin after intramuscular or subcutaneous administration to horses

Gilman, Joshua; Davis, Lloyd; Neff-Davis, C. A.; Koritz, G. D.; Baker, Gordon J.

doi:10.1111/j.1365-2885.1987.tb00084.x

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Bioavailability from subcutaneous (s.c.) sites is similar to i.m. bioavailability (Gilman et al, 1987;Jernigan et al, 1988f;Wilson et al, 1989), although the maximum concentration after S.C. administration is usually lower and occurs later after injection than that observed after an equivalent i.m. dose (Jernigan et al, 1988a;Wilson et al, 1989).…”

Section: Gen(amuinmentioning

confidence: 99%

Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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Section: Gen(amuinmentioning

confidence: 99%

Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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“…The prime site for intramuscular injection in the neck of the horse appears to be at the level of the 5th cervical vertebra, ventral to the funicular part of the ligamentum nuchae but dorsal to the brachiocephalic muscle 3 . The location of the intramuscular injection site does not affect the bioavailability (refers to rate and extent of absorption) of gentamicin (50 mg/ml solution), nor does gentamicin bioavailability differ following intramuscular or subcutaneous injection 7,20 .…”

Section: Drug Administration and Dosagementioning

confidence: 99%

Antimicrobial selection, administration and dosage : continuing education

Baggot

1998

J. S. Afr. Vet. Assoc.

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Various types of information contribute to the selection of an antimicrobial agent. Initial requirements are diagnosis of the site and nature of the infection, assessment of the severity of the infectious process and medical condition of the diseased animal; these are embodied in clinical experience. Additional considerations include identification of the causative pathogenic microorganism, knowledge of its susceptibility to antimicrobial agents (microbiological considerations) and of the pharmacokinetic properties of the drug of choice and alternative drugs, and their potential toxicity (pharmacological considerations) in the animal species. Select an antimicrobial drug and dosage form appropriate for use in the particular animal species. Usual dosage regimens may be applied, except in the presence of renal or hepatic impairment, when either modified dosage or a drug belonging to another class should be used. The duration of therapy is determined by monitoring the response both by clinical assessment and bacterial culture. A favourable clinical response is the ultimate criterion of successful therapy

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“…However, the absorption in most species is good, with peak concentrations in blood occurring within 30−90 min after intramuscular injection. It is recognized that GEN was not catabolized in the animal body and was eliminated unchanged in the urine by glomerular filtration − . Owing to its pharmacokinetic properties and high tissue affinity, the use of GEN often results in high and persistent residues and prolonged withdrawal times in animal tissues.…”

Section: Introductionmentioning

confidence: 99%

Residue Depletion of Gentamicin in Swine Tissues after Intramuscular Administration

Chen

Tang

et al. 2009

J. Agric. Food Chem.

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A sensitive and robust high-performance liquid chromatographic method with fluorescence detection (HPLC-FLD) was developed for the determination of gentamicin (GEN) residues in swine tissues. The limit of quantification (LOQ) of the method was 50 ng/g for muscle and 100 ng/g for liver and kidney. Mean recoveries at all fortification levels ranged from 82.34 to 93.20% with coefficient of variation (CV) below 5.39%. Residue depletion study of GEN in swine was performed after intramuscular injections twice daily at a dose of 4 mg/kg of bw with 12 h intervals for 5 consecutive days. The concentrations of GEN were determined in injection site, muscle, liver, and kidney by the HPLC-FLD method. The highest GEN concentration was measured in kidney, indicating that kidney was the primary target tissue for GEN residue. GEN concentrations in all examined tissues were below the maximum residue limit (MRL) recommended by the European Union (EU) at 50 days post-treatment.

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Plasma concentration of gentamicin after intramuscular or subcutaneous administration to horses

Cited by 10 publications

References 8 publications

Comparative pharmacokinetics of aminoglycoside antibiotics

Comparative pharmacokinetics of aminoglycoside antibiotics

Antimicrobial selection, administration and dosage : continuing education

Residue Depletion of Gentamicin in Swine Tissues after Intramuscular Administration

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