Plasma Concentration of Gentamicin in Turtles

Raphael, Bonnie L.; Clark, C. H.; Hudson, Rick

doi:10.2307/20094769

Cited by 21 publications

(4 citation statements)

References 3 publications

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“…Під час комплексної терапії бактеріальних та грибкових хвороб рептилій протимікробна терапія є важливим та основним компонентом [9]. Гентаміцин, який досить часто використовується за лікування інфекційних хвороб різних видів тварин, проявляє нефротоксичну дію [3,10,14,15]. Вплив парентерального введення антибіотиків, у тому числі гентаміцину, на організм рептилій вивчено недостатньо.…”

Section: вступunclassified

Pathomorphological changes of kidneys, liver and blood serum biochemical parameters in red-eared sliders (Trachemys scripta elegans Wied, 1839) as a result of gentamicin parenteral injection

Dankovych,

Chuliuk

2023

Bìol. Tvarin

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Principles of reptile treatment are significantly different from the drug therapy for mammals and birds, which is primarily due to anatomical and physiological peculiarities of reptiles. Gentamicin, which has a nephrotoxic effect, is used for the treatment of reptile infectious diseases. For the purpose of studying the effects of gentamicin of reptiles a serum biochemical analysis was conducted determining aspartate aminotransferase and alanine aminotransferase activity, urea and uric acid concentration. Two research groups of red-eared sliders (Trachemys scripta elegans) were formed for the study; every 48 hours they received an injection of gentamicin in a dose 10 mg/kg into thoracic limb muscles. The animals of the first research group were withdrawn from the experiment on the 7th day, and the animals of the second group were withdrawn on the 14th day of the research. As a result of parenteral administration of gentamicin in turtles, there is an increase in the concentration of uric acid and urea, as well as the activity of aspartate aminotransferases and alanine aminotransferases in blood serum. In the kidneys, structural changes of the glomeruli were found: alternative changes in podocytes, as well as degenerative and necrotic changes in the renal tubule epithelium. Degenerative changes of nephrocytes were accompanied by the dilation of smooth endoplasmic reticulum tubules, mitochondrial crista destruction, accumulation of autophagolysosomes, cytosomes and lysosomes in the cytoplasm. Furthermore, signs of nephrocyte apoptosis with the formation of apoptotic bodies were detected. A liver examination revealed dystrophic and necrotic changes in hepatocytes, expansion and overflow of the vessels of the venous beds.

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Section: вступunclassified

Pathomorphological changes of kidneys, liver and blood serum biochemical parameters in red-eared sliders (Trachemys scripta elegans Wied, 1839) as a result of gentamicin parenteral injection

Dankovych,

Chuliuk

2023

Bìol. Tvarin

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“…14 Red-eared sliders (Trachemys scripta elegans) are freshwater turtles that are commonly kept as pets. Plasma concentrations after IM gentamicin administration at 6 and 10 mg/kg have been described in this species, 15 but pharmacokinetic parameters for amikacin have not been reported. Despite the paucity of data, veterinary reference formularies suggest amikacin doses of up to 10 mg/kg IM once daily.…”

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confidence: 98%

Subcutaneous amikacin administration in red-eared sliders (Trachemys scripta elegans) produces prolonged detectable plasma concentrations without biochemistry evidence of impaired renal function

Hiebert,

Knych,

Hawkins

2024

ajvr

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OBJECTIVE To establish pilot data on the plasma concentrations of SC amikacin at 2 doses in red-eared sliders and evaluate concurrent plasma biochemistry parameters. ANIMALS 8 adult red-eared sliders (Trachemys scripta elegans). METHODS Amikacin was administered SC at target doses of 5 and 10 mg/kg with a 3-week washout period. Blood samples were collected at 0, 24, 48, 72, and 96 hours postadministration. Plasma amikacin concentrations were quantified using liquid chromatography tandem mass spectrometry. Plasma biochemistry analyses were performed before amikacin administration, 1 week post 5-mg/kg administration, and 1 week post 10-mg/kg administration. RESULTS Mean maximum amikacin plasma concentrations were recorded 24 hours after 5-mg/kg and 10-mg/kg dosing and were 17.5 ± 2.32 µg/mL and 23.6 ± 2.92 µg/mL, respectively. Mean plasma concentrations after 5-mg/kg dosing steadily decreased to 9.1 ± 0.92 µg/mL by 96 hours postadministration. Amikacin remained detectable in all plasma samples 3 weeks post 5-mg/kg dosing with a mean plasma concentration of 1.04 ± 0.22 µg/mL. Mean plasma concentrations after 10-mg/kg dosing did not decrease over the 96-hour study period. There were no clinically relevant changes in biochemistry parameters. CLINICAL RELEVANCE Amikacin persists at detectable plasma levels for at least 3 weeks after SC administration of a 5-mg/kg dose in red-eared sliders, which has not previously been reported in any species. No biochemistry changes consistent with renal toxicity occurred after either dose. Use caution with repeated amikacin dosing in this species until further studies can better characterize cumulative amikacin pharmacokinetics and toxic threshold.

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“…These sites are the most common injection sites in clinical reptilian medicine. Venous blood samples (1.5 mL) were obtained with a 22-gauge, 1.5-in needle, and a 3-mL syringe from the caudal vein at 0, 20, and 40 minutes and 1,2,4,8,24,48, and 72 hours after administration of ceftiofur sodium. Samples were immediately placed in heparinized blood collection tubes and chilled to 7°C until centrifugation.…”

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Pharmacokinetics of ceftiofur sodium after intramuscular or subcutaneous administration in green iguanas (Iguana iguana)

Benson

Tell²,

Young

et al. 2003

ajvr

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Plasma Concentration of Gentamicin in Turtles

Cited by 21 publications

References 3 publications

Pathomorphological changes of kidneys, liver and blood serum biochemical parameters in red-eared sliders (Trachemys scripta elegans Wied, 1839) as a result of gentamicin parenteral injection

Pathomorphological changes of kidneys, liver and blood serum biochemical parameters in red-eared sliders (Trachemys scripta elegans Wied, 1839) as a result of gentamicin parenteral injection

Subcutaneous amikacin administration in red-eared sliders (Trachemys scripta elegans) produces prolonged detectable plasma concentrations without biochemistry evidence of impaired renal function

Pharmacokinetics of ceftiofur sodium after intramuscular or subcutaneous administration in green iguanas (Iguana iguana)

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