Plasma concentration of metformin and dexamethasone after administration through Osseogate

Abstract

Background: Osseogate is a novel drug delivery route through bone marrow involving a modified implant used as the drug delivery system. The purpose of this study was to evaluate the effects of individual drug physicochemical characteristics on the pharmacokinetic behavior when using the Osseogate as administration route. Methods: Implant-mediated drug delivery systems (IMDDS) were installed in a total of 18 rabbits. After complete healing, water-soluble metformin hydrochloride was administered to one group (n ¼ 9) while poorly soluble dexamethasone was administered to the other group (n ¼ 9). The release patterns of each group were monitored for two weeks by measuring the plasma concentration of each drug. Results: Both groups showed relative sustained release. However, metformin hydrochloride showed more rapid diffusion and early termination of drug release compared with dexamethasone. Conclusions: The physicochemical properties of drugs significantly affected the release pattern through Osseogate. Further research is required to achieve controlled delivery using this route.

Effects of metformin on the bioactivity and osseointegration of dental implants: A systematic review

“… 11 , 12 High glucose levels trigger the production of advanced glycemic end products, leading to the destruction of periodontal tissues. 13 Similarly, uncontrolled diabetes also leads to increased bone loss around dental implants, which may result in implant failure 14 due to increased inflammation and impaired periodontal healing. 15…”

Metformin - A Panacea Pharmaceutical Agent through convergence revolution initiative

“…High performance liquid chromatography [9][10][11] is now considered as the method of choice for the assay of metformin because of its simplicity, rapidity, high specificity, reproducibility and sensitivity. Quite recently the plasma concentration of metformin is being determined using Liquid chromatography tandem mass spectroscopy (LC-MS/MS System) 12 .…”