Plasma concentrations of angiotensin II and aldosterone during acute left ventricular failure in the dog. Effect of converting enzyme inhibition

Hall, Christian; Karlberg, B. E.

doi:10.1007/bf01852104

Cited by 12 publications

(12 citation statements)

References 30 publications

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“…Still, the role of the hormone relative to other pathophysiologic adjustments in acute heart failure is unknown. In this condition, possible ANF effects include counteraction of the adrenal effects of angiotensin II increase [10], diuretic effect in the kidneys working in synergy with neural reflexes arising in the atria [9], and influence on cardiac output redistribution.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog

et al. 1988

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Acute ischemic left ventricular failure was induced in anesthetized dogs by repeated coronary embolization with 50 microns microspheres. Plasma concentrations of atrial natriuretic factor (ANF) were measured by radioimmunoassay of arterial and venous samples before and after failure induction. Heart failure was accompanied by a doubling of arterial ANF concentration, whereas there were only insignificant changes on the venous side. The increase in arterial ANF correlated significantly to the increase in left ventricular end-diastolic pressure, but not to the increase in right atrial pressure. Measurements of pericardial pressure indicated that a pericardial constraint acted to reduce atrial distension and thereby cardiac ANF release during failure.

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Section: Discussionmentioning

confidence: 99%

Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog

et al. 1988

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“…There is a lot of evidence to suggest that angiotensin II is involved in the production of myocardial (38)(39)(40)(41)(42)(43)(44) and vascular wall hypertrophy (45). Reduction of myocardial tissue angiotensin II by chronic treatment with ACEI in SHR has been reported (46).…”

Section: Discussionmentioning

confidence: 99%

Replacement of Regular Salt by a Novel Salt Alternative Improves the Cardiovascular Effects of the ACE Inhibitor Enalapril.

et al. 1994

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“…The inter-assay CV for plasma adrenaline and noradrenaline was 12% and 13%, respectively. The analysis of plasma renin activity, plasma angiotensin II and aldosterone concentration was performed as previously described [20].…”

Section: Neurohormonal Assaysmentioning

confidence: 99%

An experimental study of cardiac natriuretic peptides as markers of development of congestive heart failure

Klinge

Hystad

Kjekshus

et al. 1998

Scandinavian Journal of Clinical and Laboratory Investigation

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The use of cardiac peptide measurements as possible diagnostic tools in congestive heart failure has been extensively discussed in the recent literature. Therefore, the aim of this study was to establish a model of experimental chronic heart failure, and thereby perform a comparative study of secretion and circulating levels of the cardiac peptides atrial natriuretic peptide (ANP), N-terminal proatrial natriuretic peptide (N-terminal proANP) and brain natriuretic peptide (BNP) during evolving heart failure. Chronic heart failure was induced in seven pigs by rapid left atrial pacing for three weeks. The effects of failure induction were documented 24 h after pacemaker deactivation. Hemodynamic indices of cardiac preload, like pulmonary capillary wedge pressure (PCWP) and right atrial pressure (RAP), were all considerably increased compared to sham operated controls. Likewise, plasma endothelin-L, noradrenaline, renin activity, aldosterone and angiotensin II were all markedly increased. Heart failure was accompanied by significant increases in both estimated cardiac secretory rate and plasma concentrations of all three cardiac peptides, significantly correlated to the PCWP. The directional changes during evolving heart failure were similar, although the percentage increase in plasma BNP was much larger than for ANP and N-terminal proANP. In absolute molar terms, however, the BNP concentration changes were minor compared to those of the other two peptides. The larger percentage increase of BNP might indicate its superiority as a marker of heart failure development, provided a functional assay suitable for clinical use can be designed for a peptide circulating in this low concentration range.

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Plasma concentrations of angiotensin II and aldosterone during acute left ventricular failure in the dog. Effect of converting enzyme inhibition

Cited by 12 publications

References 30 publications

Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog

Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog

Replacement of Regular Salt by a Novel Salt Alternative Improves the Cardiovascular Effects of the ACE Inhibitor Enalapril.

An experimental study of cardiac natriuretic peptides as markers of development of congestive heart failure

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