Plasma concentrations of free and non-TeBG bound testosterone in women on oral contraceptives

Tremblay, Roland R.; Dubé, Jean

doi:10.1016/0010-7824(74)90099-7

Cited by 219 publications

(115 citation statements)

References 9 publications

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“…Bioavailable testosterone was measured using the method of Tremblay and Dube [14] (normal values: mean = 7.87 nmol/l; range = 3.4±12.93 nmol/l). Intraassay coefficients of reliability for total testosterone and bioavailable testosterone were 3.0 % and 5.8 %, respectively.…”

Section: Methodsmentioning

confidence: 99%

Finger and penile tactile sensitivity in sexually functional and dysfunctional diabetic men

et al. 1999

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Although not all men with diabetes mellitus report difficulty achieving and maintaining erections, factors that differentiate sexually functional from dysfunctional diabetic men have not been explored extensively. Previous research has shown that penile vibratory thresholds are related to male sexual functioning [1]. Furthermore, ageing and pathophysiology related to vascular function have been associated with decreased penile sensitivity and diminished ability to achieve and maintain erections [2]. Although not presumed to be the primary cause of erectile problems, such diminished sensitivity could compound the ischaemic, metabolic and other effects of various pathophysiological states such as diabetes. Diabetic men with erectile dysfunction have been shown to have higher penile thresholds (i. e., decreased sensitivity) than young non-diabetic men [3]. Subjective cutaneous thresholds, however, represent only the most basic of sensory processes. Equally important to sexual functioning is the perceived intensity and pleasantness of penile stimulation.Endocrine factors could also be involved in diabetic erectile dysfunction. Varying methodologies have yielded conflicting results regarding the association between testosterone concentrations and diabetic erectile capacity [4±7], with at least one study indicating lower testosterone in men with diabetes. Because testosterone concentrations have been implicated in Diabetologia (1999) 42: 336±342 Finger and penile tactile sensitivity in sexually functional and dysfunctional diabetic men

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Section: Methodsmentioning

confidence: 99%

Finger and penile tactile sensitivity in sexually functional and dysfunctional diabetic men

et al. 1999

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“…Bioavailable estradiol and testosterone (the non-sex hormone-binding globulin (SHBG)-bound fractions) were measured by an adaptation of the Tremblay and Dube ammonium-sulfate precipitation method. 24 Adiponectin levels were measured on the same serum samples in 2004 by RIA at Linco Diagnostics Laboratory (St Louis, MO, USA). Linco reported no problems with two freeze-thaw cycles for the adiponectin assay.…”

Section: Blood Measuresmentioning

confidence: 99%

Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

2006

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Objective: To assess the sex-specific association of adiponectin with multiple factors thought to influence its levels, with a special emphasis on endogenous sex hormones. Design and methods: A cross-sectional study of determinants of serum adiponectin in 873 men and 673 postmenopausal women, ages 50-92. Factors evaluated include age, body size, fat distribution, lifestyle (exercise, smoking, alcohol intake), insulin resistance, renal function and endogenous sex hormone levels (total and bioavailable testosterone and estradiol). Results: Median serum adiponectin was 50% higher in women than men (Po0.001). In unadjusted analyses, adiponectin was positively related to age, alcohol intake, high-density lipoprotein (HDL) and testosterone, and negatively related to waist girth, body mass index, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), triglycerides and bioavailable estradiol in both sexes (all Po0.01). Adiponectin was positively related to blood urea nitrogen, a measure of renal function, in men only (Po0.001). Sex-specific multivariate linear regressions adjusting for HDL and triglycerides showed that only age, HOMA-IR and sex hormones independently predicted circulating adiponectin for both men and women. Higher levels of endogenous testosterone and lower bioavailable estradiol concentrations each predicted higher adiponectin; this was true for both sexes, and was not explained by differences in age, adiposity, alcohol intake, insulin resistance or lipoprotein levels. Conclusions: The association of adiponectin with the factors studied here is strikingly similar for men and women. Sex differences in circulating adiponectin levels in older adults cannot be explained by sex hormone regulation.

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“…It has been shown that PAI-1 is of particular importance in CHD, with elevated levels predicting MI and progression of atherosclerosis in stable CHD patients (22,23). Crosssectional studies have reported a positive association between testosterone levels and tPA and a negative association with PAI-1, VIIc and fibrinogen (14,15,24). Replacement of testosterone in hypogonadal men and treatment of normal men with dehydroepiandrosterone (DHEA) reduces PAI-1 serum levels, whilst testosterone administration in healthy men also reduces plasma levels of the acute phase protein fibrinogen (23), which is an independent risk factor for CAD (25).…”

Section: Introductionmentioning

confidence: 99%

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

et al. 2005

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Objective: In women, sex hormones cause increased morbidity and mortality in patients with coronary heart disease (CHD) and adversely affect the coagulation profile. We have studied the effect of physiological testosterone replacement therapy in men on coagulation factor expression, to determine if there is an increased risk of thrombosis. Methods: Double-blind, randomized, placebo-controlled trial of testosterone in 46 men with chronic stable angina. Measurements of free, total and bioavailable testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH), estradiol, plasminogen activator inhibitor-1 (PAI-1), fibrinogen, tissue plasminogen activator (tPA) and full blood count were made at 0, 6 and 14 weeks.

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Plasma concentrations of free and non-TeBG bound testosterone in women on oral contraceptives

Cited by 219 publications

References 9 publications

Finger and penile tactile sensitivity in sexually functional and dysfunctional diabetic men

Finger and penile tactile sensitivity in sexually functional and dysfunctional diabetic men

Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

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