Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study

Bao, Wei; Dar, Sharon; Zhu, Yeyi; Wu, Jing; Rawal, Shristi; Li, Shanshan; Weir, Natalie L.; Tsai, Michael Y.; Zhang, Cuilin

doi:10.1111/1753-0407.12563

Cited by 47 publications

(43 citation statements)

References 38 publications

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“…In addition to dysregulation of glycaemia and blood pressure, maternal lipid disorders during early pregnancy, including total cholesterol, LDL‐c, non‐HDL‐c, and ApoB levels, were positively correlated with GDM. While some studies found no significant association between total and LDL cholesterol with the risk for GDM, our observations confirm the findings of other studies, which demonstrated a strong link between cholesterol levels during early gestation and GDM . ApoB is an essential component of LDL particles, and its increase during pregnancy is parallel to the increase in LDL‐c .…”

Section: Discussionsupporting

confidence: 89%

“…In contrast, no significant association was found between ApoB during early gestation and GDM in non‐PCOS women . Similarly, even though TG levels are correlated with GDM in non‐PCOS individuals, there was no significant correlation between TG levels and the risk for GDM in our PCOS cohort. Therefore, compared with women without PCOS, women with PCOS appear to have unique lipid profile that is associated with development of GDM.…”

Section: Discussioncontrasting

confidence: 82%

“…In contrast, no significant association was found between ApoB during early gestation and GDM in non-PCOS women. 31,32 Similarly, even though TG levels are correlated with GDM in non-PCOS individuals, 27,30 there was no significant correlation between TG levels and the risk for GDM in our PCOS cohort.…”

Section: Discussionmentioning

confidence: 57%

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A prospective cohort study of early‐pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome

Huang

Zhang

et al. 2018

Diabetes Metabolism Res

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 82%

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A prospective cohort study of early‐pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome

Huang

Zhang

et al. 2018

Diabetes Metabolism Res

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“…A systematic review showed that prepregnancy BMI, family history of diabetes, advanced maternal age, increased HbA1c levels, and increased insulin use during pregnancy were associated with the future development of T2DM in GDM patients [23]. During pregnancy, some studies found that high TG levels during gestation were independently associated with an increased risk of GDM [24,25]. Furthermore, Kim et al suggested that postpartum TG was one risk factor for postpartum glucose intolerance [26].…”

Section: Discussionmentioning

confidence: 99%

Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes

Lai

Fang

et al. 2020

Journal of Diabetes Research

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Background. Whether elevated triglyceride (TG) levels during pregnancy were a biomarker for postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) remained unknown. The aim of this study was to investigate the association between TG levels during the second trimester and postpartum AGM in GDM women. Methods. This was a retrospective cohort study including 513 GDM women. A 75 g oral glucose tolerance test (OGTT) was performed, and lipid levels were determined during pregnancy and the postpartum period. GDM patients were categorized into tertiles according to their TG levels at 24–28 weeks of gestation (TG<2.14 mmol/L, TG: 2.14–2.89 mmol/L, and TG>2.89 mmol/L). A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results. During pregnancy, women in the high TG tertile showed higher HbA1c levels (5.47±0.58% versus 5.28±0.49%, p=0.006), higher total cholesterol (TC) levels (5.85±1.23 mmol/L versus 5.15±0.97 mmol/L, p=0.026), and higher HOMA-IR (2.36 (1.62-3.45) versus 1.49 (0.97-2.33), p<0.001) than the participants in the low TG tertile. After delivery, the prevalence rates of AGM based on above tertiles of TG levels during pregnancy were 26.90%, 33.33%, and 43.27%, respectively (p=0.006). High TG tertile during the second trimester was associated with the presence of postpartum AGM (adjusted OR: 2.001, 95% CI: 1.054-3.800, p=0.034). Conclusions. The elevated midtrimester TG levels were not only accompanied by higher glucose and lipid levels and more severe insulin resistance at the time of the measurement but were a biomarker for postpartum AGM as well.

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“…TChol, HDLc, LDLc, and triglyceride levels were measured using plasma isolated from blood samples collected at enrollment and stored in -80°F freezers [59]. TChol, HDLc and triglycerides were directly measured using the Roche COBAS 6000 chemistry analyzer (Roche 111 Diagnostics, Indianapolis, IN).…”

Section: Maternal Lipid Profilesmentioning

confidence: 99%

Maternal dyslipidemia during early pregnancy and epigenetic ageing of the placenta

2019

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Disruption of physiological ageing of the placenta is associated with obstetric complications. Altered lipid metabolism is a known trigger of tissue ageing, but the effect of maternal dyslipidemia on placental ageing is not clearly understood. We examined the relationship between maternal dyslipidemia and placental age acceleration (PAA), an epigenetic ageing measure derived from the difference between DNA methylation age and chronological gestational age. We also assessed whether the association varies by maternal pre-pregnancy obesity status and fetal sex. Placental data were obtained as part of the NICHD Fetal Growth Studies that involved participants from four race/ethnic groups. Placental DNA methylation age was estimated using 62 CpGs that have previously been found to have high placental age prediction accuracy. We used multivariable linear regression to test associations between maternal dyslipidemia during early gestation (i.e., high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), total cholesterol (TChol), and triglycerides) and PAA adjusting for fetal sex and socio-demographic factors. Among normal-weight women, low HDLc, compared to high HDLc, was associated with 0.82 (95% CI: 0.00, 1.64) weeks higher PAA. Among women with female neonates, low HDLc, compared to high HDLc, was associated with 1.20 (95% CI: 0.17, 2.24) weeks higher PAA. High TChol was associated with 1.28 (95% CI: 0.12, 2.45) weeks higher PAA among Whites. In all, the study found that maternal dyslipidemia due to low HDLc was associated with accelerated epigenetic ageing of the placenta among mothers with normal pre-pregnancy weight and a female fetus.

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Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study

Abstract: Higher plasma triglyceride and lower HDL-C concentrations in early and mid-pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL-C concentrations during pregnancy were not significantly associated with GDM risk.

Cited by 47 publications

References 38 publications

A prospective cohort study of early‐pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome

A prospective cohort study of early‐pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome

Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes

Maternal dyslipidemia during early pregnancy and epigenetic ageing of the placenta

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