Plasma copeptin, a possible prognostic marker in cirrhosis

Abstract

In cirrhotic patients, copeptin concentrations increased along with the severity of liver disease. In our cohort, the 1-year mortality or liver transplantation was predicted by high MELD score and high concentrations of CRP and copeptin.

New vasoactive peptides in cirrhosis: organ extraction and relation to the vasodilatory state

“…Pharmacokinetics of CPT, proADM and pro-ANP have been extensively investigated, and a long half-life may cause similar concentrations in all vascular beds [16,33,34]. We found a close correlation to creatinine levels and evidence of both CPT, proADM and proANP being extracted in the kidneys, suggesting a clearance of peptides from the kidneys, previously described by Moreno et al [35]. The high levels of CPT could also be explained merely by a higher release of the peptide in patients with renal dysfunction.…”

Copeptin is an independent prognostic factor for transplant‐free survival in cirrhosis

“…In France, 123 consecutive patients were recruited from September 2011 till June 2012. Details on this cohort have been recently reported . Serum samples for copeptin measurement were drawn at hospital admission for either elective screening for LT or for acute decompensation of cirrhosis.…”

“…However, only a few studies have assessed the association between serum copeptin concentration and haemodynamic changes in cirrhotic patients . So far, one study investigated the prognostic significance of copeptin in the setting of cirrhosis using a combined endpoint of death or liver transplantation (LT) . In the present study, we aim to investigate whether copeptin is of prognostic significance on transplant‐free survival in cirrhosis, independently of clinical parameters and liver‐specific prognostic scores.…”

Fluid Biomarkers for Predicting the Prognosis of Liver Cirrhosis

“…e measurement of vasopressin is difficult, but copeptin is more stable and easier to be detected in the blood. Moreno et al [38] reported that plasma copeptin levels were increased along with the severity of liver disease in cirrhotic patients, with a 2.3-fold risk of death/liver transplantation in high-level patients compared with low-level ones, and independently predicted the 1-year mortality or liver transplantation (AUROC: 0.7). Kerbert et al [39] investigated 61 LC patients at the waiting list for liver transplantation and found that patients with low levels of serum copeptin had a significantly higher transplant-free survival rate than those with high levels of copeptin.…”