Plasma corticosterone in the rat in response to nicotine and saline injections in a context previously paired or unpaired with nicotine

Davis, Kristina W.; Cepeda-Benito, Antonio; Harraid, James H.; Wellman, Paul J.

doi:10.1007/s00213-005-2185-7

Cited by 16 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conditioned activation of the HPA axis by an appetitive US-Just as associations are readily formed between predictive cues and aversive stimuli, so too are associations between predictive cues and appetitive or rewarding stimuli. When the appetitive stimuli are drugs of abuse, such as cocaine, heroin or nicotine, predictive cues elicit conditioned activation of the HPA axis (74,76,128,572). When the appetitive stimuli are natural rewards, such as presentation of food or water to deprived rats, the conditioned responses are more complex.…”

Section: Effects Of Learning and Memory On The Hpa Axismentioning

confidence: 99%

HPA Axis Interactions with Behavioral Systems

Packard

Egan

Ulrich‐Lai

2016

Comprehensive Physiology

View full text Add to dashboard Cite

Perhaps the most salient behaviors that individuals engage in involve the avoidance of aversive experiences and the pursuit of pleasurable experiences. Engagement in these behaviors is regulated to a significant extent by an individual's hormonal milieu. For example, glucocorticoid hormones are produced by the hypothalamic-pituitary-adrenocortical (HPA) axis, and influence most aspects of behavior. In turn, many behaviors can influence HPA axis activity. These bidirectional interactions not only coordinate an individual's physiological and behavioral states to each other, but can also tune them to environmental conditions thereby optimizing survival. The present review details the influence of the HPA axis on many types of behavior, including appetitively-motivated behaviors (e.g., food intake and drug use), aversively-motivated behaviors (e.g., anxiety-related and depressive-like) and cognitive behaviors (e.g., learning and memory). Conversely, the manuscript also describes how engaging in various behaviors influences HPA axis activity. Our current understanding of the neuronal and/or hormonal mechanisms that underlie these interactions is also summarized. © 2016 American Physiological Society. Compr Physiol 6:1897-1934, 2016.

show abstract

Section: Effects Of Learning and Memory On The Hpa Axismentioning

confidence: 99%

HPA Axis Interactions with Behavioral Systems

Packard

Egan

Ulrich‐Lai

2016

Comprehensive Physiology

View full text Add to dashboard Cite

show abstract

“…The HPA axis is the main mediator of the stress-response system which nicotine, the major psychoactive ingredient in tobacco smoke, can activate. This results in increased release of adrenocorticotropic hormone (ACTH) and glucocorticoids (CORT) in adult rats (Fuxe et al, 1989, Matta et al, 1998, Davis et al, 2005, Rhodes et al, 2001, Lutfy et al, 2006). Although nicotine can interact with peripheral neuronal nicotinic acetylcholine receptors (nAChR) located in the peripheral nervous system and in the adrenal medulla (Dávila-García et al, 2003), it is believed that nicotine acts centrally via activation of nAChRs located in the brainstem to stimulate the HPA axis.…”

Section: Introductionmentioning

confidence: 99%

Acute nicotine activates c-fos and activity-regulated cytoskeletal associated protein mRNA expression in limbic brain areas involved in the central stress-response in rat pups during a period of hypo-responsiveness to stress

et al. 2008

View full text Add to dashboard Cite

In adult rats, acute nicotine, the major psychoactive ingredient in tobacco smoke, stimulates the hypothalamic-pituitary-adrenal axis (HPA), resulting in activation of brain areas involved in stress and anxiety-linked behavior. However, in rat pups the first two postnatal weeks are characterized by hypo-responsiveness to stress, also called the 'stress non-responsive period' (SNRP). Therefore, we wanted to address the question if acute nicotine stimulates areas involved in the stress response during SNRP? To determine neuronal activation, the expression of the immediate-early genes c-fos and Arc was studied in the central nucleus of the amygdala (CeA), bed nucleus stria terminalis (BST) and paraventricular hypothalamic nucleus (PVN), which are areas involved in the neuroendocrine and central stress response. Rat pups received nicotine tartrate (2 mg/kg) or saline by i.p. injection at postnatal day (P) 5, 7 and 10 and their brains were removed after 30 min. We used semi-quantitative radioactive in situ hybridization with gene specific antisense cRNA probes in coronal sections. In control pups, c-fos expression was low in most brain regions, but robust Arc hybridization was found in several areas including cingulate cortex, hippocampus and caudate. Acute nicotine resulted in significant induction of c-fos expression in the PVN and CeA at P5, P7 and P10, and in the BST at P7 and P10. Acute nicotine significantly induced expression of Arc in CeA at P5, P7 and P10, and in the BST at P10. In conclusion, acute nicotine age dependently activated different brain areas of the HPA axis during the SNRP. After P7, the response was more pronounced and included the BST, suggesting differential maturation of the HPA axis in response to nicotine.

show abstract

“…Acute administration of nicotine activates the hypothalamic-pituitary-adrenal axis resulting in increased plasma corticosterone in both male and female adult and adolescent rats, effects that are more pronounced in adult females compared to adult males [27][28][29]. Experimental data from rats show that nicotine does not act directly at the hypothalamic paraventricular nucleus, the site of the corticotrophinreleasing factor neurons crucial to the regulation of adrenocorticotropic hormone (ACTH).…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Nicotine Induced Dyslipidemia and Hyperglycemia in Mice

Bano

2021

J. Basic Appl. Sci.

View full text Add to dashboard Cite

The purpose of this study is to examine the prevalence of metabolic syndrome in nicotine treated male and female mice and to evaluate gender related differences. For these purposes adult male and female BALB/C mice were subjected to chronic nicotine treatment (3.08mg/100ml in drinking water) for 4 weeks. Serum glucose, albumin, corticosterone and lipid profile levels were determined. Body weight changes were also monitored. We have found that nicotine treatment raises total cholesterol and glucose levels more in male as compared to female mice. Low density lipoprotein cholesterol (LDL-C) levels were increased by 35% (P<0.01) only in male mice. However rise in triglycerides were greater in females (28%) than males (21%) when compared with their respective controls. Serum albumin levels were increased in both sexes showing 13% greater increase in males as compared to females. However nicotine treatment had no effect on high density lipoprotein cholesterol, corticosterone levels and body weights in both genders. It is concluded that nicotine use is positively associated with LDL-C in males; the results are discussed in relation to prevalence of metabolic syndrome and risk of cardiovascular events in nicotine users.

show abstract

Plasma corticosterone in the rat in response to nicotine and saline injections in a context previously paired or unpaired with nicotine

Abstract: The results supported the notion that a CS associated with nicotine effects elicit a conditioned response (CR) in the form of CORT release. Future research will be needed to examine whether conditioned CORT release can explain the context-dependent attenuations of nicotine-induced CORT.

Cited by 16 publications

References 27 publications

HPA Axis Interactions with Behavioral Systems

HPA Axis Interactions with Behavioral Systems

Acute nicotine activates c-fos and activity-regulated cytoskeletal associated protein mRNA expression in limbic brain areas involved in the central stress-response in rat pups during a period of hypo-responsiveness to stress

Gender Differences in Nicotine Induced Dyslipidemia and Hyperglycemia in Mice

Contact Info

Product

Resources

About