Plasma cortisol in cattle: Circadian rhythm and exposure to a simulated high altitude of 5,000 m

Hays, F. L.; Armbruster, H.; Vetter, W; Bianca, W.

doi:10.1007/bf01463869

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…Blood samples from the jugular vein were withdrawn via venipuncture 30 min before sham disbudding and disbudding (baseline), at sham disbudding and disbudding (0 min) and 30 min, 2 h, 6 h, 12 h, and 24 h after disbudding into BD Vacutainer tubes spray-coated with lithium heparin (BD Vacutainer). Due to a possible diurnal rhythm of cortisol concentrations (Hays et al, 1975), disbudding was always performed at the same time as sham disbudding. The blood collection times were the same for sham disbudding as for disbudding.…”

Section: Blood Sample Collectionmentioning

confidence: 99%

The effect of transdermal flunixin meglumine on blood cortisol levels in dairy calves after cautery disbudding with local anesthesia

Röder

Heuwieser

Borchardt

et al. 2022

Journal of Dairy Science

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The objective of this study was to evaluate the effect of the nonsteroidal anti-inflammatory drug transdermal flunixin meglumine (Finadyne Transdermal) on plasma cortisol, average daily weight gain, and standing and lying behavior of calves, when given at the time of disbudding combined with local anesthesia. A sedative was not used to minimize pharmacological interactions. Seventy-one female Holstein Friesian calves aged 13 ± 2 d, with an average weight of 48.9 ± 4.26 kg were enrolled in the study. All calves were randomly assigned to one of 3 treatment groups: (1) control group (CON, n = 27), (2) 1-flunixin group (1-FLU, n = 26) with a single administration of transdermal flunixin meglumine at disbudding, and (3) 2-flunixin group (2-FLU, n = 24) with 2 administrations of transdermal flunixin meglumine, the first treatment at disbudding and the second 6 h after disbudding. Although the CON group received a placebo, 1-FLU and 2-FLU received flunixin meglumine transdermally. To account for plasma cortisol changes due to manipulation and handling of the calves, a sham disbudding procedure was performed one week before disbudding took place. Sham disbudding was conducted by using a cold cautery dehorner applied to each horn bud for 10 s. Disbudding was performed in a similar way by using a hot cautery dehorner. Plasma samples were collected to measure the stress biomarker cortisol at 7 different time points. Body weights were measured 4 times in 2 wk. Standing and lying behavior was assessed via 3-dimensional accelerometer. During sham disbudding and disbudding mean plasma cortisol concentrations were 6.09 ± 2.5 ng/mL and 5.16 ± 2.8 ng/mL, respectively. Treatment tended to have an effect on plasma cortisol concentrations during sham disbudding and had an effect on plasma cortisol concen-trations during disbudding. Plasma cortisol concentrations were affected by treatment 2 h after disbudding in comparison to CON group. Furthermore, there was a significant effect on plasma cortisol concentrations 6 h after disbudding in contrast to CON. A return to baseline plasma cortisol levels (initial concentrations) was not achieved in CON during disbudding. There was no statistical difference between average daily weight gain and the treatment procedure. Total lying time was not affected by treatment after disbudding. In conclusion, transdermal flunixin meglumine given at the time of disbudding combined with local anesthesia decreased concentrations of the stress biomarker cortisol, but a second dose 6 h after disbudding had no further effect on plasma cortisol levels.

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Section: Blood Sample Collectionmentioning

confidence: 99%

The effect of transdermal flunixin meglumine on blood cortisol levels in dairy calves after cautery disbudding with local anesthesia

Röder

Heuwieser

Borchardt

et al. 2022

Journal of Dairy Science

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“…6. They lie around the following simulated altitudes: Respiratory rate: 1700 m, blood-pH: 2500 m (to 3500 m), rectal temperature: 2800 m, heart rate and haematocrit: 3200 m. Also included is the point for eortisol, 3200 m, which is derived from an earlier experiment (Hays et al, 1975).…”

Section: Comparisonsmentioning

confidence: 99%

Responses of calves to a simulated altitude of 5000 m

Bianca¹,

Hays

1975

Int J Biometeorol

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ABSTRACT.-Six calves were exposed in succession 12 days at 400 m altitude (control), 12 days at a simulated altitude of 5000 m in a low pressure chamber (experimental), and 14 days at 400 m altitude (recovery). Exposure to 5000 m produced the following changes : intake of feed and water decreased by 47 and 35% respectively, and body weight gain ceased. Rectal temperature rose by 0.4oc. Heart rate increased by 65%. Respiratory rate and blood pH increased moderately. There was an S-shaped rise of haematocrit (from 33 to 45%), which was paralleled by blood viscosity. Plasma viscosity showed a sharp, but transient rise. Short term measurements made during ascent to and descent from 5000 m altitude, both lasting for four hours, showed that some of the changes developed rapidly.

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Metabolic and Endocrine Changes at Altitude

Blume

1984

High Altitude and Man

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Plasma cortisol in cattle: Circadian rhythm and exposure to a simulated high altitude of 5,000 m

Cited by 9 publications

References 17 publications

The effect of transdermal flunixin meglumine on blood cortisol levels in dairy calves after cautery disbudding with local anesthesia

The effect of transdermal flunixin meglumine on blood cortisol levels in dairy calves after cautery disbudding with local anesthesia

Responses of calves to a simulated altitude of 5000 m

Metabolic and Endocrine Changes at Altitude

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