Plasma Cortisol in Sickle Cell Disease

Osifo, Bola O.A.; Lukanmbi, F.A.; Adekile, Adekunle

doi:10.1159/000205689

Cited by 7 publications

(7 citation statements)

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“…In this study, our observation was similar to that of Osifo et al [7] as we observed that cortisol level was lower in SCA patients but, increased significantly during painful crisis toward the level in control subjects. This is similar to the observed elevated level of CRP in the VOC group compared with the SCA subjects in steady state.…”

Section: Discussionsupporting

confidence: 92%

“…They observed that plasma cortisol concentrations were diminished during painful crises. Osifo et al [7] reported that cortisol production is lower in SCA patients but, increases during painful crisis. In contrast, Saad and Saad [41] infused synthetic adrenocorticotropic hormone in SCA subjects in steady state and observed that the subjects had similar level of cortisol compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…High cortisol levels likely reflect more severe stress, whereas low levels may point to an insufficient response to stress, labelled relative adrenal insufficiency. Osifo et al [7] and el-Hazmi et al [8] reported that there is low cortisol production in SCA patients compared to individuals with HbAS or HbAA and that the level does not truly assess stress level in SCA patients especially during crisis. However, a variety of unique stress situations cannot be well addressed by a single mediator but through a combination of multiple mediators such as arginine vasopressin (AVP), cortisol, noradrenalin, orexin, urocortins and dopamine among others [9].…”

Section: Introductionmentioning

confidence: 99%

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Serum Copeptin and Cortisol Do Not Accurately Predict Sickle Cell Anaemia Vaso-Occlusive Crisis as C-Reactive Protein

et al. 2013

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ObjectiveThis study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA).DesignProspective case-control studyMethodsSixty consecutive SCA subjects (18–40 years) comprising 30 subjects in the steady state and 30 subjects in vaso-occlusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data obtained were statistically analyzed using the Student’s t-test and Mann Whitney U as appropriate and P<0.05 was considered significant.ResultsSCA subjects in VOC had significantly lower copeptin level and significantly higher CRP level compared with controls. However, serum levels of copeptin, cortisol and CRP were significantly higher in SCA subjects in VOC compared with SCA subjects in steady state. Furthermore, CRP had the widest Area under the ROC curve (AUROC) than copeptin and cortisol. No significant difference was observed in the levels of copeptin, CRP and cortisol when SCA subjects in VOC who were hospitalized for less ≤5 days were compared with subjects who had longer stays.ConclusionIt could be concluded that C-reactive protein has a superior diagnostic performance for vaso-occlusive crisis in individuals with sickle cell anaemia and that C-reactive protein, cortisol and copeptin are not good prognostic markers in SCA subjects in vaso-occlusive crisis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Copeptin and Cortisol Do Not Accurately Predict Sickle Cell Anaemia Vaso-Occlusive Crisis as C-Reactive Protein

et al. 2013

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“…In one report by Osifo et al, the mean plasma cortisol level in HbSS steady-state SCA patients was significantly lower than patients with no SCA; however, only 8% of SCA patients had plasma cortisol below the normal range 22. In another report, basal plasma cortisol levels were lower in children with the HbSS genotype compared with those of other genotypes 4.…”

Section: Discussionmentioning

confidence: 92%

Hormonal and echocardiographic abnormalities in adult patients with sickle-cell anemia in Bahrain

Garadah

Jaradat

Al-Alawi

et al. 2016

JBM

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BackgroundAdrenal, thyroid, and parathyroid gland hormonal changes are recognized in children with homozygous (HbSS) sickle-cell anemia (SCA), but are not clear in adult patients with SCA.AimTo assess the metabolic and endocrine abnormalities in adult patients with SCA and evaluate left ventricular (LV) systolic and diastolic functions compared with patients with no SCA and further study the relationship between serum levels of cortisol, free thyroxine (T4), and testosterone with serum ferritin.Materials and methodsThe study was conducted on 82 patients with adult HbSS SCA compared with a sex- and age-matched control group. The serum levels of cortisol, parathyroid hormone (PTH), testosterone, thyroid-stimulating hormone (TSH), and free T4 were compared. Blood levels of hemoglobin, reticulocyte count, lactate dehydrogenase (LDH), calcium, alkaline phosphatase (ALP), vitamin D3, and ferritin were also compared. Pulsed Doppler echo was performed to evaluate the LV mass, wall thickness, and cavity dimensions with diastolic filling velocities of early (E) and atria (A) waves. Biometric data were analyzed as mean ± standard deviation between the two groups. Multiple regression analysis was performed between serum levels of ferritin as independent variable and testosterone, cortisol, and thyroid hormones.ResultsA total of 82 adult patients with HbSS SCA were enrolled who had a mean age of 21±5.7 years, with 51 males (62%). Patients with SCA compared with the control group had significantly lower hemoglobin, body mass index, cortisol, vitamin D3, testosterone, and T4. Furthermore, there were significantly high levels of reticulocyte count, PTH, TSH, ferritin, LDH, ALP, and uric acid. The incidence of subclinical hypothyroidism and adrenal insufficiency was 7% and 4.8%, respectively, with hypogonadism 9.8% and vitamin D3 deficiency 61%. There were inverse relationships between ferritin as independent variable and serum levels of testosterone, T4, and cortisol, with regression coefficients of −0.49 (P<0.001), −0.33 (P<0.001), and −0.11 (P<0.92), respectively.ConclusionPatients with adult SCA had a high prevalence of in vivo hypoadrenialism (4.8%), hypogonadism (9.8%), and hypothyroidism (7%). There were significant inverse relationships between serum ferritin as independent variable and cortisol, testosterone, and T4. Pulsed Doppler echocardiography showed increased LV mass, with a restrictive LV diastolic pattern suggestive of diastolic dysfunction.

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“…Plasma triiodothyronine and thyroxine concentrations were normal in children and adolescents with HbSS (31,35), but plasma triiodothyronine concentrations were decreased in adult men with HbSS (40). Plasma cortisol concentrations were significantly lower in children with HbSS than in control children (39). Plasma concentrations of growth hormone were lower in adolescents but greater in young adults with HbSS compared with controls (37).…”

Section: E360mentioning

confidence: 99%

Alterations in basal nutrient metabolism increase resting energy expenditure in sickle cell disease

Borel

Buchowski²,

Turner

et al. 1998

American Journal of Physiology-Endocrinology and Metabolism

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Basal rates of whole body protein, glucose, and lipid metabolism and resting energy expenditure (REE) were measured in eight African-American sickle cell disease (SCD) patients and in six African-American controls. Catheters were placed 1) in an antecubital vein for stable isotope infusion and 2) in a heated hand vein for arterialized venous blood. Breath and blood were collected during the last 30 min of the 2.5-h study, and REE was measured by indirect calorimetry. REE [128 ± 5 vs. 111 ± 1 kJ ⋅ kg fat-free mass (FFM)−1 ⋅ day−1; P < 0.05 vs. controls] was 15% greater in the SCD patients. Whole body protein breakdown (5.0 ± 0.3 vs. 3.8 ± 0.2 mg ⋅ kg FFM−1 ⋅ min−1; P < 0.05 vs. controls) and protein synthesis (4.4 ± 0.3 vs. 3.2 ± 0.2 mg ⋅ kg FFM−1 ⋅ min−1; P< 0.05 vs. controls) were 32 and 38% greater, respectively, in the SCD patients, but whole body amino acid oxidation was similar (0.58 ± 0.03 vs. 0.66 ± 0.03 mg ⋅ kg FFM−1 ⋅ min−1). Measures of whole body glucose and lipid metabolism were not significantly different between the groups. The additional energy required for the greater rates of whole body protein breakdown and synthesis caused by SCD contributes significantly to the observed increase in REE, suggesting that dietary energy and protein requirements are enhanced in SCD patients.

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Plasma Cortisol in Sickle Cell Disease

Cited by 7 publications

References 0 publications

Serum Copeptin and Cortisol Do Not Accurately Predict Sickle Cell Anaemia Vaso-Occlusive Crisis as C-Reactive Protein

Serum Copeptin and Cortisol Do Not Accurately Predict Sickle Cell Anaemia Vaso-Occlusive Crisis as C-Reactive Protein

Hormonal and echocardiographic abnormalities in adult patients with sickle-cell anemia in Bahrain

Alterations in basal nutrient metabolism increase resting energy expenditure in sickle cell disease

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