Plasma creatine kinase activity and exercise-induced muscle damage in older men

Manfredi, Thomas G.; Fielding, Roger A.; O’Reilly, Kevin; Meredith, C. N.; Lee, Ho Yong; Evans, William J.

doi:10.1249/00005768-199109000-00006

Cited by 154 publications

(141 citation statements)

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“…This is most evident in animal models where greater immediate post-eccentric force deficits have been observed in lower limb muscles of old vs. young or middle-aged animals (Zerba et al 1990;Brooks and Faulkner 1996;Lynch et al 2008). However, findings have been mixed regarding the effect of age on the susceptibility to eccentric-induced muscle injury in human subjects with some reporting an exaggerated response in the elderly (Manfredi et al 1991), others finding no difference between young and old (Dedrick and Clarkson 1990), and some finding less injury in the elderly (Lavender and Nosaka 2006a).…”

Section: Introductionmentioning

confidence: 99%

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Choi

Lim

Nibaldi

et al. 2011

AGE

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Muscles of old laboratory rodents experience exaggerated force losses after eccentric contractile activity. We extended this line of inquiry to humans and investigated the influence of fiber myosin heavy chain (MHC) isoform content on the injury process. Skinned muscle fiber segments, prepared from vastus lateralis biopsies of elderly men and women (78± 2 years, N=8), were subjected to a standardized eccentric contraction (strain, 0.25 fiber length; velocity, 0.50 unloaded shortening velocity). Injury was assessed by evaluating pre-and post-eccentric peak Ca 2+ -activated force per fiber cross-sectional area (F max ). Over 90% of the variability in post-eccentric F max could be explained by a multiple linear regression model consisting of an MHC-independent slope, where injury was directly related to pre-eccentric F max , and MHC-dependent y-intercepts, where the susceptibility to injury could be described as type IIa/IIx fibers>type IIa fibers>type I fibers. We previously reported that fiber type susceptibility to the same standardized eccentric protocol was type IIa/IIx>type IIa=type I for vastus lateralis fibers of 25-year-old adults (Choi and Widrick, Am J Physiol Cell Physiol 299:C1409-C1417, 2010). Modeling combined data sets revealed significant age by fiber type interactions, with posteccentric F max deficits greater for type IIa and type IIa/ IIx fibers from elderly vs. young subjects at constant pre-eccentric F max . We conclude that the resistance of the myofilament lattice to mechanical strain has deteriorated for type IIa and type IIa/IIx, but not for type I, vastus lateralis fibers of elderly adults.

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Section: Introductionmentioning

confidence: 99%

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Choi

Lim

Nibaldi

et al. 2011

AGE

Self Cite

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“…In early studies, CK activity was closely related to the magnitude of muscle damage [8], while later studies demonstrated that CK activity was not correlated with the degree of muscle damage [29]. Later studies biopsied the vastus lateralis muscle after high-force eccentric exercise in young and old males and then observed morphological changes using an electron microscope [29].…”

Section: Discussionmentioning

confidence: 99%

“…Later studies biopsied the vastus lateralis muscle after high-force eccentric exercise in young and old males and then observed morphological changes using an electron microscope [29]. The authors concluded that older individuals had greater morphological disruption compared to young individuals but there was no significant difference in CK activity between the two groups.…”

Section: Discussionmentioning

confidence: 99%

The relationship of creatine kinase variability with body composition and muscle damage markers following eccentric muscle contractions

Kim¹,

Lee²

2015

J. Exerc. Nutr, Biochem.

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Jooyoung Kim and Joohyung Lee. The relationship of creatine kinase variability with body composition and muscle damage markers following eccentric muscle contractions. JENB., Vol. 19, No. 2, pp.123-129, 2015 [Purpose] The purpose of the study was to investigate the relationship between CK variability and body composition and muscle damage markers following eccentric exercise.[Methods] Total 119 healthy male subjects were recruited to perform 50 eccentric contractions consisted of 2 sets of 25 contractions. Then, blood creatine kinase (CK) activity was analyzed to divide into three groups based on their CK activity levels. Maximum isometric strength (MIS), muscle soreness (SOR) and body composition data were obtained before and after exercise. [Results]The results showed that high CK responders had a significant decrease in MIS (p < 0.001) and greater SOR (p < 0.01) following eccentric exercise compared to low CK responders. Percent body fat was also higher in high responders compared to low responders (p = 0.014). Peak CK activity was significantly correlated with MIS and SOR but no correlation with % body fat, muscle mass, and body mass index.[Conclusion] CK variability following eccentric exercise is closely related to MIS and SOR and % body fat may be a potent factor for CK variability.

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“…Estudos prévios questionam a relação entre a DMIT 11 e o extravasamento de CK com outros marcadores de dano muscular, indicando que estes marcadores não são bons preditores da magnitude de dano muscular induzido pelo exercício 5,11,12,14 . Um dos questionamentos em relação a utilização da CK como marcador indireto de dano muscular é pelo fato da molécula de CK possuir grande massa molecular (80 kDa) e, portanto, teria dificuldade em entrar no endotélio microvascular 15 .…”

Section: Discussionunclassified

“…Desta forma, um pequeno grau de dano muscular que não altere significativamente a permeabilidade da membrana, não faria com que houvesse extravasamento de CK para a corrente sanguínea. O presente estudo, mesmo classificando os indivíduos em grupos baixos e altos respondedo- Indivíduos Média cluster ± DP res à queda de CVM, não observou diferenças significantes na atividade sérica de CK corroborando com estudos que indicam que a análise do extravasamento de proteínas intramusculares na corrente sanguínea deve ser desencorajado para propostas de quantificação de prejuízos funcionais e/ou do grau de dano muscular induzido por EE 12,14 . No que concerne a DMIT, Nosaka et al 11 demonstraram com uma amostra de 110 homens jovens que a dor muscular tardia possui correlações fracas ou mesmo inexistentes com outros marcadores indiretos de dano muscular (e.g.…”

Section: Discussionunclassified

Dor muscular e atividade de creatina quinase após ações excêntricas: uma análise de cluster

Chacon-Mikahil

Vechin

Berton

et al. 2014

Rev Bras Med Esporte

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rEsumoIntrodução: O exercício excêntrico máximo promove queda da capacidade de geração de força, aumento de dor muscular de início tardio (DMIT) e extravasamento de creatina quinase (CK) no sangue. No entanto, essas respostas ao exercício excêntrico demonstram alta variabilidade interindivíduos. Objetivos: Classificar e analisar essas respostas segundo a vulnerabilidade individual, por meio da magnitude da redução dos níveis de força após exercício excêntrico. Métodos: Dezoito sujeitos (11 homens e sete mulheres com idade entre 18 e 71 anos) saudáveis realizaram cinco séries de seis ações excêntricas máximas para flexores do cotovelo em dinamômetro isocinético (90°s -1 , amplitude de movimento de 80 a 20°). Foram analisadas contração voluntária muscular concêntrica máxima (CVM), DMIT e CK pré, pós (exceto CK), 24 h, 48 h, 72 h e 96 h após o protocolo. Os indivíduos foram classificados como "baixos" (BR) e "altos" respondedores (AR) ao pico de queda de CVM pós-exercício seguindo-se uma análise de cluster e comparação entre grupos para CVM, DMIT e CK com teste-t independente. Resultados: A comparação entre BR e AR indicou maiores valores de queda de CVM para o grupo AR (AR: -30,7 ± 3,3%; BR: -14,1 ± 2,2%, p < 0,001) e maior DMIT também para o grupo AR (AR: 33,0 ± 8,6 mm; BR: 10,2 ± 2,5 mm, p = 0,033); no entanto, os valores de pico de atividade de CK não diferiram entre os grupos (AR: 232,1 ± 54,8 UI.L , p = 0,490). Conclusão: A classificação dos indivíduos em grupos de baixos e altos respondedores foi importante para demonstrar que o grupo mais responsivo à queda de força após exercício excêntrico também evidencia maiores níveis de DMIT; contudo, para a CK essa relação não pôde ser estabelecida.Palavras-chave: exercício, força muscular, músculo esquelético, treinamento de resistência. AbstrACt

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Plasma creatine kinase activity and exercise-induced muscle damage in older men

Cited by 154 publications

References 0 publications

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

The relationship of creatine kinase variability with body composition and muscle damage markers following eccentric muscle contractions

Dor muscular e atividade de creatina quinase após ações excêntricas: uma análise de cluster

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