Plasma Cytokeratin‐18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease

Mandelia, Chetan; Collyer, Elizabeth; Mansoor, Sana; López, Rocío; Lappe, Sara; Nobili, Valério; Alkhouri, Naim

doi:10.1097/mpg.0000000000001136

Cited by 47 publications

(41 citation statements)

References 39 publications

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“…Therefore, we used CK-18 fragment as a surrogate of the severity of liver injury and fibrosis. 23,24 In conclusion, the present study confirms PNPLA3, GCKR and…”

Section: Discussionsupporting

confidence: 87%

“…We surely cannot perform liver biopsy as a screening method in the general population. Therefore, we used CK‐18 fragment as a surrogate of the severity of liver injury and fibrosis …”

Section: Discussionmentioning

confidence: 99%

“…Caspase‐cleaved CK18 fragment has been validated as a useful biomarker of liver injury and fibrosis for NAFLD in adults and children . In the subgroup analysis, we categorized the study subjects as non‐NAFLD (negative hepatic steatosis and a value of CK‐18 fragment < 233 U/L), simple hepatic steatosis (positive hepatic steatosis and a value of CK‐18 fragment < 233 U/L), and presumed NASH (positive hepatic steatosis and a value of CK‐18 ≥ 233 U/L).…”

Section: Methodsmentioning

confidence: 99%

“…Caspase-cleaved CK18 fragment has been validated as a useful biomarker of liver injury and fibrosis for NAFLD in adults and children. [22][23][24] In the subgroup analysis, we categorized the study subjects…”

Section: Statisticalanalysismentioning

confidence: 99%

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Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Lin

Chang

et al. 2018

Liver International

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“…Therefore, we used CK-18 fragment as a surrogate of the severity of liver injury and fibrosis. 23,24 In conclusion, the present study confirms PNPLA3, GCKR and…”

Section: Discussionsupporting

confidence: 87%

“…We surely cannot perform liver biopsy as a screening method in the general population. Therefore, we used CK‐18 fragment as a surrogate of the severity of liver injury and fibrosis …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Statisticalanalysismentioning

confidence: 99%

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Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Lin

Chang

et al. 2018

Liver International

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“…CK18 M30 level is also correlated with fibrosis in children with NAFLD 32 . Other studies also found in patients with chronic hepatitis C, M30 is associated with fibrosis instead of steatosis 33 .…”

Section: Discussionmentioning

confidence: 92%

Complementary Role of Fibroblast Growth Factor 21 and Cytokeratin 18 in Monitoring the Different Stages of Nonalcoholic Fatty Liver Disease

Fang

et al. 2017

Sci Rep

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Fibroblast growth factor 21 (FGF21) and cytokeratin 18 (CK18) were previously reported to be elevated in nonalcoholic fatty liver disease (NAFLD). We aim to analyze the differential roles of FGF21, cell apoptosis marker CK18 fragment M30 and total cell death marker CK18 M65ED in monitoring the different stages of NAFLD spectrum in a population-based prospective cohort comprising 808 Chinese subjects. Predictive performances for monitoring the different stages of NAFLD were assessed by logistic regression and receiver-operating characteristic (ROC) curves. We found baseline FGF21 but not CK18 level was an independent predictor for the development of simple steatosis. NAFLD patients who had remission during follow-up had significantly lower baseline M30 levels than those who sustained NAFLD (84.74U/L [53.26–135.79] vs. 118.47U/L [87.16–188.89], P = 0.012). M65ED was independently predictive of progressing to suspected non-alcoholic steatohepatitis (NASH) in NAFLD patients. These results suggest that FGF21 can be used for early identification of hepatic steatosis. On the other hand, CK18 including M30 and M65ED, are predictive of the prognosis of NAFLD patients. FGF21 and CK18 might play differential roles and have complementary value in non-invasive identification and monitoring the outcome of NAFLD patients.

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Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children

et al. 2022

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IMPORTANCE Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture effects. Furthermore, the association between prenatal EDC exposure and hepatocellular apoptosis in children has not been studied previously.OBJECTIVE To investigate associations of prenatal exposure to EDC mixtures with liver injury risk and hepatocellular apoptosis in childhood.

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Plasma Cytokeratin‐18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease

Abstract: CK18 is a promising noninvasive biomarker for fibrosis in NAFLD in children. A fibrosis prediction model that includes CK18 and waist circumference percentile should be validated in other populations.

Cited by 47 publications

References 39 publications

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

Complementary Role of Fibroblast Growth Factor 21 and Cytokeratin 18 in Monitoring the Different Stages of Nonalcoholic Fatty Liver Disease

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children

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