Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy

Ernberg, Malin; Christidis, Nikolaos; Ghafouri, Bijar; Bilevičiūtė-Ljungar, Indrė; Löfgren, Monika; Bjersing, Jan; Palstam, Annie; Larsson, Anette; Mannerkorpi, Kaisa; Gerdle, Björn; Kosek, Eva

doi:10.1155/2018/3985154

Cited by 64 publications

(126 citation statements)

References 60 publications

(90 reference statements)

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“…inflammatory cytokines. 12,13 However, there have been inconsistencies in these findings with results from previous studies (i.e., plasma levels of various catecholamines have been increased, decreased, or unchanged). 14 Despite intensive research focusing on multiple biologically plausible markers to aid in the diagnosis and prognostication of disease activity in FM, further understanding of the biological perturbations is needed to better explain potential underlying mechanisms related to FM and to guide personalized health strategies for symptom management.…”

Section: Metabolomic Differentials In Fibromyalgiamentioning

confidence: 71%

“…A variety of physiological factors are purported to be involved in the pathophysiology of FM, including genetic vulnerability, altered levels of neurotransmitters, and immune system/inflammatory factors; however, no one etiologic target or set of targets has been determined . For example, researchers have suggested that chronic low‐grade systemic inflammation may contribute to both the initiation and maintenance of the centralized pain state, focusing their studies on peripheral blood markers in FM, including inflammatory cytokines . However, there have been inconsistencies in these findings with results from previous studies (i.e., plasma levels of various catecholamines have been increased, decreased, or unchanged) …”

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confidence: 99%

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Metabolomic Differentials in Women With and Without Fibromyalgia

Menzies

Starkweather

Yao

et al. 2019

Clinical Translational Sci

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A nontargeted plasma metabolomic analysis was conducted to compare differentially expressed metabolites in women with and without fibromyalgia (FM) using data and samples collected from two parent studies in women with FM (n = 20) and comparative data collected from newly recruited age‐matched women (n = 20). Blood plasma samples were analyzed for metabolite content using liquid chromatography mass spectrometry. Consolidation of positive and negative ion mode metabolomics data with fold change (>2 or <0.5) and variable importance of projection scores ≥1 revealed statistically significant metabolites comparing samples from women with and without FM. Metabolite profiles in patients with FM differed from the comparison group in energy, lipid and amino acid metabolites reflecting heightened oxidative stress, inflammation, and tryptophan degradation in patients with FM. Study results may contribute to further identification of unique metabolomic profiles enhancing understanding of the pathophysiology of FM and for the development of effective therapeutic options.

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Section: Metabolomic Differentials In Fibromyalgiamentioning

confidence: 71%

mentioning

confidence: 99%

Metabolomic Differentials in Women With and Without Fibromyalgia

Menzies

Starkweather

Yao

et al. 2019

Clinical Translational Sci

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“…As described above, there were originally 260 participants in the multi-centre study: 130 women with FM and 130 HC. Plasma levels of cytokines and chemokines for the total cohort were previously analysed (28). Plasma samples from 100 participants were available for analysis of NGF and BDNF and consequently only those subjects were included in this study; 75 out of the 100 were women with FM and 25 were HC.…”

Section: Subjectsmentioning

confidence: 99%

“…Psychometric variables and PPT were registered at baseline (both FM and HC) and after the interventions (only in FM). Data have previously been presented for the total cohort (FM: n = 130 and HC: n = 125) (28,31). Details about the variables are presented in those studies (28,31).…”

Section: Variables Registeredmentioning

confidence: 99%

“…Binding of NGF to TrkA and p75 can activate transcription factors, such as nuclear factor NF-κB and production of tumour necrosis factor alpha (TNF-α), and interleukins IL-1β, IL-2, IL-6, IL-8, and IL-12 (24). Elevated levels of IL-8 in blood and in CSF have been reported in FM (25)(26)(27), but less consistent alterations have been reported in other cytokines, such as IL-6, IL-1β, and IL-2 (28,29). More complex alterations in plasma patterns of inflammatory substances have been reported recently in FM/widespread pain (27,30).…”

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Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Jablochkova¹,

Bäckryd²,

Mannerkorpi³

et al. 2019

J Rehabil Med

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LAY ABSTRACTPatients with fibromyalgia have treatment-resistant chronic pain. More research is needed in order to understand how and why fibromyalgia develops. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia, but few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. This study compared blood levels of nerve growth factor and brain-derived neurotrophic factor in fibromyalgia with those in healthy controls, and investigated the effect of exercise on these levels. Brain-derived neurotrophic factor levels were higher and levels of nerve growth factor were lower in fibromyalgia, compared with healthy controls. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotro phins, such as nerve growth factor and brainderived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hy peralgesia. Few studies have examined circulating nerve growth factor and brainderived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these pep tides. Objectives: To compare plasma levels of nerve growth factor and brainderived neurotrophic factor in fibromyalgia and in healthy controls, to investiga te correlations between levels of nerve growth fac tor, brainderived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15week intervention, and 25 healthy controls participated at baseline. Patients were ran domized to a 15week progressive resistance exer cise intervention or a relaxation intervention. Results: Brainderived neurotrophic factor level was significantly higher (p < 0.001) and nerve growth factor level was significantly lower (p < 0.001) in fi bromyalgia than in healthy controls. Neither resis tance exercise nor relaxation interventions affec ted the levels of brainderived neurotrophic factor or nerve growth factor. No significant correlations were found between brainderived neurotrophic fac tor or nerve growth factor plasma levels in fibromy algia and cytokine levels or clinical variables. Conclusion: Changes in circulating nerve growth factor and brainderived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brainderived neuro trophic factor and nerve growth factor were not nor malized.

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Clinical relevance of resistance training in women with fibromyalgia: A systematic review and meta‐analysis

Rodríguez‐Domínguez,

Rebollo‐Salas,

Chillón‐Martínez

et al. 2023

European Journal of Pain

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Background and ObjectiveThere has been an increase in the number of papers assessing the effects of resistance training (RT) in patients with fibromyalgia. Therefore, the objective of our study was to evaluate the clinical relevance and effectiveness of RT for pain intensity, functionality and severity of the disease specifically in women with fibromyalgia through a systematic review with meta‐analysis.Databases and Data TreatmentSeven databases were searched. Randomized controlled trials conducted in women over 18 years of age with fibromyalgia were included. Fifteen trials were included in the systematic review and 14 of these studies were included in the three meta‐analyses performed. Study quality assessment was performed using the PEDro scale. In addition, the GRADE recommendations were used.ResultsThe global meta‐analysis revealed statistically significant differences in the RT group versus the control group on pain intensity (SMD = −0.49; 95% CI [−0.74, −0.24], p = 0.0001), functionality (SMD = −0.23; 95% CI [0.01, 0.45], p = 0.04) and on severity of the disease (SMD = −0.58; 95% CI [−0.90, −0.26], p = 0.0005). Clinically relevant improvements in the overall outcome of the three variables studied in favour of RT were obtained.ConclusionsRT is effective to improve pain intensity, functionality and severity of the disease in women with fibromyalgia. These improvements are clinically relevant. More clinical trials of RT are needed in women with fibromyalgia to support our results due to the low strength of evidence.SignificanceThis systematic review with meta‐analysis provides evidence that RT produces clinically relevant improvements in women with fibromyalgia. The absence of immediate benefit is often a major barrier to adherence to treatment. Our findings will help clinicians to empower patients that if they continue treatment, they will achieve improvement in their disease.

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Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy

Cited by 64 publications

References 60 publications

Metabolomic Differentials in Women With and Without Fibromyalgia

Metabolomic Differentials in Women With and Without Fibromyalgia

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Clinical relevance of resistance training in women with fibromyalgia: A systematic review and meta‐analysis

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