Plasma Dehydroepiandrosterone Sulphate in Hypothyroid Premenopausal Women

Bassi, Francesca; Pupi, Alberto; Giannotti, P.; Fiorelli, G; Forti, Gianni; Pinchera, Aldo; Serio, Mario

doi:10.1111/j.1365-2265.1980.tb01031.x

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…(1983) and Tagawa et al . (2000) reported similar results, and also Bassi et al . (1980) reported a marked reduction of plasma DHEA‐S in idiopathic hypothyroidism in women.…”

Section: Discussionsupporting

confidence: 69%

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Yamakita

Murai

Kokubo

et al. 2001

Clinical Endocrinology

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The balance of the conversion between DHEA-S and DHEA in the hyperthyroid state favoured DHEA-S. Similar to cortisol, the DHEA response in the CRH test in hyperthyroidism seemed to be insufficiently compensated for by increased ACTH, although the DHEA response to low-dose ACTH was similar in the hyperthyroid and euthyroid states. Increased DHEA-S might play some role in the pathological states in many organs in hyperthyroidism.

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“…(1983) and Tagawa et al . (2000) reported similar results, and also Bassi et al . (1980) reported a marked reduction of plasma DHEA‐S in idiopathic hypothyroidism in women.…”

Section: Discussionsupporting

confidence: 69%

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Yamakita

Murai

Kokubo

et al. 2001

Clinical Endocrinology

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“…Although alternative explanations for the lower levels of this anabolic hormone in HF have been offered (28,29), lower DHEAS levels in HF could also be interpreted in the light of a hypothyroid state. Lower DHEAS levels have previously been reported in hypothyroid women (30). It has been suggested that the lower concentrations of DHEA and DHEAS in hypothyroidism could be explained by decreased adrenal steroidogenesis (31).…”

Section: Discussionmentioning

confidence: 90%

Low plasma triiodothyronine levels in heart failure are associated with a reduced anabolic state and membrane damage

Brenta

Thierer

Sutton

et al. 2011

European Journal of Endocrinology

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Background: Low plasma triiodothyronine (T 3 ) levels are considered a prognostic predictor of death in heart failure (HF) patients. Aim: To study an association between plasma T 3 levels and several cardiac, neurohormonal, and metabolic markers of HF. Methods: A total of 133 ambulatory HF patients (114 males; mean age 63.2 years) with left ventricular ejection fraction !40% were enrolled. TSH, total tetraiodothyronine (T 4 ) and T 3 , N-terminal pro-brain natriuretic peptide (NT-proBNP), and other cardiac and metabolic parameters were measured. The lowest tertile of T 3 (group 1) was compared against the two upper ones (group 2). Results: In simple logistic regression, the lowest T 3 tertile was associated with more advanced HF disease status: older (age: odds ratio (OR)Z1.05; confidence interval (CI) 95% 1.01-1.09, PZ0.004), lower functional capacity (walking test: ORZ0.996; CI 95% 0.993-0.999, PZ0.008), higher NT-proBNP (ORZ1.64; CI 95% 1.19-2.27, PZ0.003) and adiponectin levels (ORZ1.07; CI 95% 1.02-1.11, PZ0.004), lower DHEAS log-transformed (ORZ0.50; CI 95% 0.31-0.80, PZ0.004), and the presence of lower phase angle values as measured by body bioelectrical impedance analysis (ORZ3.18; CI 95% 1.50-6.71, PZ0.04) and worse renal function (ORZ0.96; CI 95% 0.94-0.98, PZ0.003). T 3 levels in the lowest tertile were independently associated with low phase angle values (ORZ2.95, CI 95% 1.16-7.50, PZ0.02) and the log transformation of DHEAS (ORZ0.56; CI 95% 0.32-0.97, PZ0.04). Conclusion: We have demonstrated an association between plasma T 3 levels in the lower range and other deranged hormonal and metabolic parameters in HF patients.

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“…In 1980, Bassi and colleagues [80] reported lower DHEAS concentrations in hypothyroid patients. Three years later, Foldes et al [81] reported decreased DHEA and DHEAS in hypothyroid patients and increased DHEAS, but not DHEA, in patients with Graves' disease.…”

Section: Thyroid Hormonementioning

confidence: 97%

DHEAS as a new diagnostic tool

Leowattana

2004

Clinica Chimica Acta

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Plasma Dehydroepiandrosterone Sulphate in Hypothyroid Premenopausal Women

Cited by 12 publications

References 13 publications

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Dehydroepiandrosterone sulphate is increased and dehydroepiandrosterone‐response to corticotrophin‐releasing hormone is decreased in the hyperthyroid state compared with the euthyroid state

Low plasma triiodothyronine levels in heart failure are associated with a reduced anabolic state and membrane damage

DHEAS as a new diagnostic tool

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