Plasma deposited acrylic acid coatings: Surface characterization and attachment of 3T3 murine fibroblast cell lines

Anti‐microbial coatings by agent entrapment in coatings deposited via atmospheric pressure plasma liquid deposition

“…Seventy-nine percent of CO 2 H was retained for a 10 min deposition from atmospheric-pressure glow discharge at 1.5 kV. By comparison, the time taken to deposit the ppAAc coating described in this work was 15 s. Additionally, in the work by Detomaso et al 9 the CO 2 H component is not distinguished from CO 2 X, and as such the retention may be even lower than 12%.…”

Covalent immobilization of liposomes on plasma functionalized metallic surfaces

“…PdAA coatings deposited at higher plasma power, i.e., in high monomer fragmentation conditions, maintain instead their surface composition (lower density of -COOH groups, lower wettability, etc.) unaltered after immersion in water for 50 h. Stable pdAA coatings are thus characterized by relatively low surface density of -COOH groups (<10% with respect to the total number of surface carbon atoms) still suitable though, for improving directly cell adhesion [24], and for immobilizing RGD peptides through the formation of amide bonds [35].…”

“…Increasing RF power and/or temperature, lead to pdAA coatings stable in water and DCM, but with limited surface density of -COOH groups (<8% with respect to all surface carbon atoms, according to XPS analysis), which were found in any case suitable for immobilizing liposomes. We do not present here all data relative to the effect of plasma parameters in the deposition of pdAA coatings, some of which have been previously published [21,24].…”

“…Chemical composition, hydrophilic and polar character, morphology and charge of material surfaces can be easily adjusted by properly tuning experimental plasma parameters such as input power, flow rate, composition of feed gas, and others [14,15,18]. By feeding the discharge with proper gas/vapors, e.g., with NH 3 to graft N-containing functional groups onto polymers, or with acrylic acid (AA) or other suitable mixtures to deposit coatings characterized by a certain density of -COOH groups [19][20][21][22][23], it is possible to functionalize surfaces of biomedical interest, where the chemical groups could be possibly used for optimal surface interactions of the modified material with protein and cells [24] or in further conventional surface modification reactions for the direct immobilization of biomolecules [25]. This approach allows to develop new biomedical materials characterized by drug-eluting capability, or by the ability to imitate, to some extent, the proper environment for cell adhesion and growth, as in the extracellular matrix of living tissues.…”

On the interaction of non-thermal atmospheric pressure plasma with tissues

“…Similarly, non-thermal plasma appears to kill bacteria on the surface of living tissue without histologically visible damage [2]. It has been reported that non-thermal plasma can also mediate attachment of cells to substrates [4][5][6], increase transfection efficiency [7,8] and surface sterilization [9][10][11][12]. Ability to tune nonthermal plasma effects together with the simplicity of plasma generating devices and localized nature of plasma application makes it a promising tool in medicine.…”