Plasma deposited APTES: A potential film for biomedical application

Chen, Zilin; Zhao, Junjie; Chen, Jin; Yuan, Yidie; Zhang, Yongping; Tatoulian, Michaël; Rao, Xi

doi:10.1016/j.matlet.2020.127350

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…One possible method to ensure this is to modify the ceramic surface by introducing functional groups that improve adhesion, e.g., -SH, -CN-COOH, -NH 2 , and -SiH 4 [14]. Due to the simplicity of applications and the possibility to obtain good adhesion between ceramics and polymers, silanization has received much attention [14][15][16][17]. Silanization is a proven way to introduce silane coupling agents that can be used to improve the surface properties and introduce reactive functional groups on ceramic surfaces [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

et al. 2021

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This paper describes the effect of calcination temperature on the phase composition, chemical composition, and morphology of ZrO2 and Al2O3 powders modified with 3-aminopropyltriethoxysilane (APTES). Both ceramic powders were modified by etching in piranha solution, neutralization in ammonia water, reaction with APTES, ultrasonication, and finally calcination at 250, 350, or 450 °C. The obtained modified powders were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, particle size distribution (PSD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), and thermogravimetric analysis (TGA).

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Section: Introductionmentioning

confidence: 99%

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

et al. 2021

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“…Despite its excellent processability and previous in vitro and in vivo applications for bone tissue engineering, PEOT/PBT demonstrates poor cell attachment upon cell seeding. , The organosilane monomers (3-aminopropyl)trimethoxysilane (APTMS) and maleic anhydride-vinyltrimethoxysilane (MA-VTMOS) were used to deposit polymer-like thin films containing amine and carboxyl functional groups, respectively, by plasma polymerization in argon on the PEOT/PBT scaffold surface. Despite being already explored to modify 2D surfaces, , these monomers were used here for the first time to treat 3D scaffolds. Compared to other precursors, organosilanes possess the advantage of providing a stable siloxane backbone to the coating, which is highly adherent and resistant to delamination in water conditions, ensuring good functional group retention under cell culture conditions. , Pristine scaffolds, plasma-polymerized scaffolds, and argon plasma-activated scaffolds were seeded with hMSCs.…”

Section: Introductionmentioning

confidence: 99%

Tuning Cell Behavior on 3D Scaffolds Fabricated by Atmospheric Plasma-Assisted Additive Manufacturing

Cámara-Torres

Sinha

Scopece³

et al. 2021

ACS Appl. Mater. Interfaces

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Three-dimensional (3D) scaffolds with optimum physicochemical properties are able to elicit specific cellular behaviors and guide tissue formation. However, cell–material interactions are limited in scaffolds fabricated by melt extrusion additive manufacturing (ME-AM) of synthetic polymers, and plasma treatment can be used to render the surface of the scaffolds more cell adhesive. In this study, a hybrid AM technology, which combines a ME-AM technique with an atmospheric pressure plasma jet, was employed to fabricate and plasma treat scaffolds in a single process. The organosilane monomer (3-aminopropyl)trimethoxysilane (APTMS) and a mixture of maleic anhydride and vinyltrimethoxysilane (MA-VTMOS) were used for the first time to plasma treat 3D scaffolds. APTMS treatment deposited plasma-polymerized films containing positively charged amine functional groups, while MA-VTMOS introduced negatively charged carboxyl groups on the 3D scaffolds’ surface. Argon plasma activation was used as a control. All plasma treatments increased the surface wettability and protein adsorption to the surface of the scaffolds and improved cell distribution and proliferation. Notably, APTMS-treated scaffolds also allowed cell attachment by electrostatic interactions in the absence of serum. Interestingly, cell attachment and proliferation were not significantly affected by plasma treatment-induced aging. Also, while no significant differences were observed between plasma treatments in terms of gene expression, human mesenchymal stromal cells (hMSCs) could undergo osteogenic differentiation on aged scaffolds. This is probably because osteogenic differentiation is rather dependent on initial cell confluency and surface chemistry might play a secondary role.

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“…Also, according to our findings, the physicochemical characteristics of coatings that were produced with this precursor remained practically unchanged after 1‐year storage in a humid environment. [ 23 ] Furthermore, as Chen et al [ 26 ] recently showed, plasma polymerization of APTES produces coatings with good stability in water that would be promising for applications, such as antibacterial materials, biosensors, drug immobilization in immobilization/release systems, and for improving the bioactivity and biocompatibility of implants. Nevertheless, to the best of our knowledge, no work has been published reporting the antibiofilm effects of plasma‐polymerized APTES functional coatings.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of biofilm formation on polystyrene substrates by atmospheric pressure plasma polymerization of siloxane‐based coatings

Múgica‐Vidal

Sainz‐García

Muro-Fraguas

et al. 2021

Plasma Processes & Polymers

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Biofilms pose important economic and health risks in biomedical applications and in food industries. In this study, coatings that reduce the biofilm formation of Pseudomonas aeruginosa on polystyrene cell culture plates are deposited by plasma polymerization of (3‐aminopropyl)triethoxysilane using an atmospheric pressure plasma jet system at three different power levels. Surface characterizations and quantification of biofilm formation during 1 week after deposition suggest that the higher concentration of oxygenated carbon groups on the coated samples than on uncoated ones can induce higher levels of oxidative stress in the bacteria in contact with the coatings. This causes an initial overproduction of extracellular polymeric substances that can avoid further bacterial attachment and biofilm formation at later cycles of biofilm development.

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Plasma deposited APTES: A potential film for biomedical application

Cited by 7 publications

References 22 publications

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

Tuning Cell Behavior on 3D Scaffolds Fabricated by Atmospheric Plasma-Assisted Additive Manufacturing

Inhibition of biofilm formation on polystyrene substrates by atmospheric pressure plasma polymerization of siloxane‐based coatings

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