Plasma deposited stability enhancement coating for amorphous ketoprofen

Bosselmann, Stephanie; Owens, Donald E.; Kennedy, Rachel L.; Herpin, Matthew J.; Williams, Robert O.

doi:10.1016/j.ejpb.2010.12.011

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…The second and third type of interaction can be associated with aliphatic C-C and C=O bonds. Their energy shift versus the primary spectral component is +1.0 for C–C and +3.5 eV for C=O type of bonds and highly correlates with other results found in the literature [ 41 , 42 , 43 ]. Furthermore, the XPS analysis carried out within the O1s energy region confirmed the pronounced presence of peak located at 533.1 eV, which is characteristic for carbonyl bonds.…”

Section: Resultssupporting

confidence: 89%

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Bogdanowicz

Niedziałkowski

Sobaszek

et al. 2018

Sensors

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In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.

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Section: Resultssupporting

confidence: 89%

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Bogdanowicz

Niedziałkowski

Sobaszek

et al. 2018

Sensors

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show abstract

“…Previous studies have found that coating the surface of an amorphous solid can inhibit surface crystallization . However, the coating techniques of these studies (see section Introduction ) can only be applied to the product particle size.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have found that coating the surface of an amorphous solid can inhibit surface crystallization. 7,8,[14][15][16][17][18] However, the coating techniques of these studies (see section Introduction) can only be applied to the product particle size. Although this may be suitable for amorphous solids with a relatively slow surface crystallization rate, Figure 9 readily shows the disadvantages of these types of coating processes for highly unstable amorphous solids and solid dispersions for APIs such as APAP.…”

Section: Inhibition Of Surface-enhanced Crystallizationmentioning

confidence: 99%

Enhanced Physical Stability of Amorphous Drug Formulations via Dry Polymer Coating

Capece

Davé

2015

Journal of Pharmaceutical Sciences

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“…Plasma polymerization, also known as plasmaenhanced chemical vapor deposition (PECVD), a dry coating method, was chosen to deposit thin hydrophobic polymer films on the surface of amorphous ketoprofen (KET)/ Methocel™ E5 aggregate particles 107 .…”

Section: Plasma Enhanced Chemical Vapor Deposition (Pecvd): Figure 2:mentioning

confidence: 99%

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2012

IJPSR

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Plasma deposited stability enhancement coating for amorphous ketoprofen

Cited by 10 publications

References 43 publications

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Enhanced Physical Stability of Amorphous Drug Formulations via Dry Polymer Coating

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