Plasma Deposition and Treatment for Biomaterial Applications

Ratner, Buddy D.; Chilkoti, Ashutosh; López, Gabriel P.

doi:10.1016/b978-0-12-200430-8.50013-0

Cited by 109 publications

(57 citation statements)

References 104 publications

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“…Plasma-based methods, ionizing radiation, and other advanced technologies have recently been applied to low-temperature sterilization and decontamination. Successful attempts were made to sterilize surfaces in low-pressure rfGD plasma operating below 1 Torr as early as the 1960s [134]. Usually, low-pressure glow discharge plasma is employed in combination with a working gas familiar to the healthcare and medical community, such as hydrogen peroxide or paracetic acid vapor.…”

Section: Plasma Sterilizationmentioning

confidence: 99%

“…Table 1 lists some of the more common research areas and applications of plasma treatment in biomaterials [14] and Table 2 shows the advantages of plasma deposited films in biomaterial applications [1]. More information can be found in the article of Ratner et al [15]. With regard to ion implantation, Table 3 lists some of the main historical events [16].…”

Section: Introductionmentioning

confidence: 99%

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Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,424

652

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Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

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Section: Plasma Sterilizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,424

652

View full text Add to dashboard Cite

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“…Other surface characteristics that can be improved by PSM are wettability, refractive index, chemical inertness, hardness and lubricity, by introducing new functional groups depending on the gas used (e.g. O 2 , N 2 ) [14][15]. N 2 -containing plasmas are often used to modify the surface of polymers due to their ability to incorporate functionalities such as amine moieties on the surface structure of materials [7][8].…”

Section: Introductionmentioning

confidence: 99%

Active screen plasma nitriding enhances cell attachment to polymer surfaces

Kaklamani

Bowen

Mehrban

et al. 2013

Applied Surface Science

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Active Screen Plasma Nitriding (ASPN) is a well-established technique used for the surface modification of materials, the result of which is often a product with enhanced functional performance. Here we report the modification of the chemical and mechanical properties of ultra-high molecular weight poly(ethylene) (UHMWPE) using 80:20 (v/v) N 2 /H 2 ASPN, followed by growth of 3T3 fibroblasts on the treated and untreated polymer surfaces. ASPN-treated UHMWPE showed extensive fibroblast attachment within three hours of seeding, whereas fibroblasts did not successfully attach to untreated UHMWPE. Fibroblast-coated surfaces were maintained for up to 28 days, monitoring their metabolic activity and morphology throughout. The chemical properties of the ASPN-treated UHMWPE surface were studied using X-ray photoelectron spectroscopy, revealing the presence of C-N, C=N, and C≡N chemical bonds. The elastic modulus, surface topography, and adhesion properties of the ASPN-treated UHMWPE surface were studied over 28 days during sample storage under ambient conditions and during immersion in two commonly used cell culture media. KeywordsActive screen plasma nitriding, atomic force microscopy, fibroblast, interferometry, nanoindentation, X-ray photoelectron spectroscopy 2 1. Introduction Biomaterials that will be used for medical applications are required to have excellent bulk and surface properties to resist mechanical deformation while providing a surface that enables tissue attachment. Designing a material that exhibits good bulk properties together with the appropriate surface characteristics to enable biological integration is often challenging [1][2][3]. Polymeric materials exhibit attractive characteristics for biomedical applications. They are of low density, are easy to process and of relatively low cost. It has also been reported that polymers can be tailored to influence the viability, growth and function of attached cells controlling the cell function by the chemical, morphological and mechanical properties of the polymeric surface [4]. The surface properties of polymers, however, do not often satisfy the requirements for biomedical applications such as scratch resistance, wettability, biocompatibility, gas permeability and friction. They often appear to have low surface energy and poor adhesive properties hence surface modification is required [5][6][7][8].

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“…one to bypass several of the just quoted shortcomings After being polished the specimens were solvent of polymer coatings on inorganic surfaces. 16,17 In parcleaned in methylethylketone for 5 min, washed in ticular, it allows the production of an adherent, pinultrapure water for 20 min, acid passivated in 30% hole, and additive-free surface layer resistant to hynitric acid for 30 min, according to the ASTM procedrolysis and delamination in humid environments. 17 dure, 22 and rinsed again in ultrapure water for 20 min.…”

Section: Introductionmentioning

confidence: 99%

Organic surface chemistry on titanium surfaces via thin film deposition

Morra¹,

Cassinelli²

1997

J. Biomed. Mater. Res.

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In order to develop a synthetic strategy for the fine tuning of the interfacial properties of titanium-based implants and implant parts, a thin polymeric film was deposited from ethylene plasma on the surfaces of Ti foils. The intended aim was to further modify the adherent, delamination-resistant organic coating using the techniques of surface modification of polymers to direct interfacial interactions at the metal foil-biological phase interface. In particular, air-plasma treatment and Ce(IV)-induced hydroxyethylmethacrylate grafting, two typical reactions of biomedical polymers surface chemistry, were used to improve cell adhesion or to impart cell resistance to the plasma-coated Ti. Results indicate that a plasma-deposited thin polymeric film effectively can act as a viable substrate for further surface chemical modifications and allow the application of a huge background of surface-modification polymers to metallic devices.

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Plasma Deposition and Treatment for Biomaterial Applications

Cited by 109 publications

References 104 publications

Plasma-surface modification of biomaterials

Plasma-surface modification of biomaterials

Active screen plasma nitriding enhances cell attachment to polymer surfaces

Organic surface chemistry on titanium surfaces via thin film deposition

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