Plasma dopamine-?-hydroxylase activity as a measure of sympathetic activity during halothane anaesthesia in children

Planz, G.; Yılmaz, Ercan; Palm, D.

doi:10.1007/bf00644737

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…The level of circulating DBH recorded in the 10-year-old boy (mean value 14 nmoles/ minlml) was slightly higher than that reported for this age-group (Freedman et al, 1972) and much higher than that reported by Planz and co-workers for the same range of age (Planz, Yilmaz & Palm, 1973). Anaesthesia decreased serum DPH and in this connection the low levels of DPH observed during the later period of the operatian is most interesting (Fig.…”

Section: Discussioncontrasting

confidence: 45%

Circulating Dopamine-?-Hydroxylase (D?h) and Catecholamines in a Paediatric Phaeochromocytoma

Helle

Serck‐Hanssen

Søvik

et al. 1976

Clin Exp Pharmacol Physiol

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1. Circulating catecholamines and dopamine-beta-hydroxylase (DbetaH) have been studied in a child with bilateral phaeochromocytoma. 2. Venous catheterization showed a great increase in catecholamine efflux from the left adrenal vein while DbetaH activity in the latter was only slightly elevated. 3. Circulating catecholamines fluctated greatly while DbetaH activity decreased gradually during the removal of the tumours. 4. Post-operatively, circulating catecholamines declined to normal values while DbetaH activity returned to pre-operative levels. 5. It is concluded that these tumours released circulating catecholamines independent of an exocytotic secretion of DbetaH and that the circulating DbetaH reflected the activity of the sympathetic nervous system.

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Section: Discussioncontrasting

confidence: 45%

Circulating Dopamine-?-Hydroxylase (D?h) and Catecholamines in a Paediatric Phaeochromocytoma

Helle

Serck‐Hanssen

Søvik

et al. 1976

Clin Exp Pharmacol Physiol

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Drug Action, Reaction, and Interaction

Aviado

1975

The Journal of Clinical Pharma

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Correlation between increased dopamine-?- hydroxylase activity and catecholamine concentration in plasma: Determination of acute changes in sympathetic activity in man

Planz

Wiethold

Appel

et al. 1975

Eur J Clin Pharmacol

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In 11 healthy untrained volunteers the increase in plasma dopamine-beta-hydroxylase (DBH) activity during graded physical exercise has been examined as a true measure of increased activity of the sympathetic nervous system. The correlation between DBH activity, catecholamine concentration (CA) in plasma and heart rate was studied. When work on an electrically braked bicycle ergometer was gradually increased from 12.5 to 100, 200 and 300 watts there was a linear increase in DBH activity and heart rate; the increase in CA concentrations followed an exponential function. The peak values for DBH activity and CA concentration in plasma after the 300 watt work load (as percentages of the resting levels) were 130+/-3% and 820+/-71%, respectively; the adrenaline concentration in plasma increased only to 150+/-19% (p less than 0.05). There were significant correlations between heart rate and work load, DBH and work load and log CA and work load. The data imply direct correlations between heart rate and DBH, heart rate and log CA and DBH and log CA. The exponential increase in noradrenaline concentration in plasma might be due either to a greater net ""overflow'' from sympathetic nerve endings, and/or to increased secretion by the adrenal medulla. In the latter case, the release of noradrenaline would not be accompanied by secretion either of adrenaline or DBH. After work ceased there were sharp falls in heart rate and CA concentration, which indicate an immediate drop in sympathetic activity. DBH activity in plasma returned to normal very slowly; it reached half maximum values after 20-22 min. It is concluded that increased sympathetic activity in man can be estimated in vivo as changes in DBH and/or CA concentration in plasma. In contrast, a rapid decrease in sympathetic activity is directly reflected only by a rapid fall in the plasma concentrations of CA.

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Plasma dopamine-?-hydroxylase activity as a measure of sympathetic activity during halothane anaesthesia in children

Cited by 7 publications

References 25 publications

Circulating Dopamine-?-Hydroxylase (D?h) and Catecholamines in a Paediatric Phaeochromocytoma

Circulating Dopamine-?-Hydroxylase (D?h) and Catecholamines in a Paediatric Phaeochromocytoma

Drug Action, Reaction, and Interaction

Correlation between increased dopamine-?- hydroxylase activity and catecholamine concentration in plasma: Determination of acute changes in sympathetic activity in man

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