Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients

Mårtensson, Johan; Jönsson, Niklas; Glassford, Neil J; Bell, Max; Martling, Claes‐Roland; Bellomo, Rinaldo; Larsson, Anders

doi:10.1186/s13613-016-0108-x

Cited by 29 publications

(31 citation statements)

References 31 publications

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“…Thirty studies161718192021222324252627282930313233343536373839404142434445 finally met the inclusion criteria via full-text evaluation from 156 potentially eligible citations. Seven studies21222324252627 were selected from the previous meta-analysis (Zhang, et al .…”

Section: Resultsmentioning

confidence: 99%

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Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

Yong

Pei

Zhu

et al. 2017

Sci Rep

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The role of serum cystatin C (Scys) for the detection of acute kidney injury (AKI) has not been fully discussed. This meta-analysis was aimed to investigate the overall diagnostic accuracy of Scys for AKI in adults, and further identify factors affecting its performance. Studies before Sept. 2016 were retrieved from PubMed, Embase, Web of Science and the Cochrane Library. A total of 30 prospective cohort studies (involving 4247 adults from 15 countries, 982 patients occurring AKI) were included. The revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tools demonstrated no significant bias had influenced the methodological quality of the included studies. Scys showed a high predictive power for all-cause AKI, that the area under the receiver operating characteristic curve was 0.89. The detailed assessment parameters, such as sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio for Scys were 0.82, 0.82, 4.6, 0.22 and 21, respectively. Although Scys could be slightly influenced by the following factors: settings, AKI diagnostic criteria, ethnicity, determination method, age and gender, these factors above did not reach statistically significance. In conclusion, Scys could be a vital promising marker to screen out AKI.

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Section: Resultsmentioning

confidence: 99%

“…GaygIsIz et al 19. and Martensson et al 20. found that the predict values (AUROC) of Scys was 0.67, with low sensitivity and specificity.…”

mentioning

confidence: 99%

Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

Yong

Pei

Zhu

et al. 2017

Sci Rep

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“…However, with accumulating evidence, conflicting results have raised. Gaygısız et al [27] and Martensson et al [28] found that the predictive value (AUC) of sCyC was 0.67, with low sensitivity and specificity. In the present study, we found that a 30% increase in sCyC was highly accurate in diagnosing CSA-AKI, with AUC 0.843 (75% sensitivity and 80% specificity).…”

Section: Discussionmentioning

confidence: 99%

Use of Both Serum Cystatin C and Creatinine as Diagnostic Criteria for Cardiac Surgery-Associated Acute Kidney Injury and Its Correlation with Long-Term Major Adverse Events

Che

Wang

Xie

et al. 2019

Kidney Blood Press Res

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Background/Aims: Cardiac surgery-associated acute kidney injury (CSA-AKI) was traditionally defined as an increase in serum creatinine (sCr) after cardiac surgery. Recently, serum cystatin C (sCyC) has been proposed to be a better biomarker in the prediction of AKI. The clinical utility and performance of combining sCyC and sCr in patients with AKI, particularly for the prediction of long-term outcomes, remain unknown. Methods: We measured sCyC together with sCr in 628 patients undergoing cardiac surgery. sCyC and sCr were assessed at baseline and 24 and 48 h after surgery. CSA-AKI determined by sCr (CSA-AKI_sCr) was defined as an sCr increase greater than 0.3 mg/dL or 50% from baseline. Major adverse events (MAEs; including death of any cause and dialysis) at 3 years were assessed. Results: CSA-AKI_sCr developed in 178 patients (28.3%). Three-year follow-up was available for 621 patients; MAEs occurred in 42 patients (6.8%). An increase in sCyC concentration ≥30% within 48 h after surgery was detected in 228 patients (36.3%). This was the best sCyC cutoff for CSA-AKI_sCr detection (negative predictive value = 88.8%, positive predictive value = 58.3%). To evaluate the use of both sCyC and sCr as CSA-AKI diagnostic criteria, we stratified patients into 3 groups: non-CSA-AKI, CSA-AKI detected by a single marker, and CSA-AKI detected by both markers. By multivariable logistic regression analysis, the independent predictors of MAEs at 3 years were group 2 (non-CSA-AKI group as the reference, CSA-AKI detected by a single marker: odds ratio [OR] = 3.48, 95% confidence interval [CI]: 1.27–9.58, p = 0.016), group 3 (CSA-AKI detected by both markers: OR = 5.12, 95% CI: 2.01–13.09; p = 0.001), and baseline glomerular filtration rate (OR = 2.24; 95% CI: 1.27–3.95; p = 0.005). Conclusion: Combining sCyC and sCr to diagnose CSA-AKI would be beneficial for risk stratification and prognosis in patients after cardiac surgery.

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“…Recently, multiple other functions of endostatin have been discovered beyond its anti-angiogenic properties. For example, it can modulate androgen receptor function (Lee et al, 2015) and prevent sepsis or acute kidney injury (Peng et al, 2015;Mårtensson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Endostatin inhibits fibrosis by modulating the PDGFR/ERK signal pathway: an in vitro study

Ren

2017

J. Zhejiang Univ. Sci. B

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Accumulating evidence indicates that endostatin inhibits fibrosis. However, the mechanism is yet to be clarified. The aim of this study is to evaluate the effect of endostatin on platelet-derived growth factor-BB (PDGF-BB)-or transforming growth factor β1 (TGF-β1)-induced fibrosis in cultured human skin fibroblasts, and to further examine the molecular mechanisms involved. Human dermal fibroblasts were cultured in Dulbecco's modified Eagle's medium (DMEM) and serum-starved for 48 h before treatment. Cells were grouped as follows: "PDGF-BB", "PDGF-BB+ endostatin", "TGF-β1", "TGF-β1+endostatin", "endostatin", and "blank control". The fibroblasts were stimulated with either TGF-β1 or PDGF-BB for 72 h in order to set up the fibrosis model in vitro. The cells were co-cultured with either TGF-β1 or PDGF-BB and endostatin and were used to check the inhibiting effect of endostatin. A blank control group and an endostatin group were used as negative control groups. The biomarkers of fibrosis, including the expression of collagen I, hydroxyproline, and α-smooth muscle actin (α-SMA), were evaluated using an enzyme-linked immunosorbent assay (ELISA) and Western blot. The expression of phosphorylated PDGF receptor β (p-PDGFRβ), PDGFRβ, phosphorylated extracellular signal-regulated kinase (p-ERK), and ERK was detected using Western blot and immunofluorescent staining was used to explore the mechanisms. Both PDGF-BB and TGF-β1 significantly up-regulated the expression of collagen I, hydroxyproline, and α-SMA. Endostatin significantly attenuated both the PDGF-BB-and TGF-β1-induced over-expression of collagen I, hydroxyproline, and α-SMA. PDGF-BB and TGF-β1 both promoted the expression of PDGFR, ERK, and p-ERK. Endostatin inhibited the expression of PDGFR and p-ERK but did not affect the expression of total ERK. Endostatin inhibited hypertrophic scar by modulating the PDGFRβ/ERK pathway. Endostatin could be a promising multi-target drug in future fibrosis therapy.

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Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients

Cited by 29 publications

References 31 publications

Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

Use of Both Serum Cystatin C and Creatinine as Diagnostic Criteria for Cardiac Surgery-Associated Acute Kidney Injury and Its Correlation with Long-Term Major Adverse Events

Endostatin inhibits fibrosis by modulating the PDGFR/ERK signal pathway: an in vitro study

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