Plasma Endothelial Microparticles and Their Correlation With the Presence of Hypertension and Arterial Stiffness in Patients With Type 2 Diabetes

Abstract

Microparticles (MPs) are associated with several cardiovas-cular complications. As multifunction biomarkers, they may contribute to the pathogenesis of diabetes-associated vas-cular diseases. A total of 39 patients with diabetes and hypertension, 24 patients with diabetes without hyper-tension, and 20 healthy controls were enrolled. Flow cytometry was applied to detect plasma MPs, including endothelial MPs (EMPs), annexin V+MPs, platelet-derived MPs (PMPs), and leukocyte-derived MPs (LMPs). Brachial ankle pulse wave velocity (baPWV) was also performed in admission. Plasma EMPs, annexin V+MPs, PMPs, and LMPs in diabetics with or without hypertension were higher than those in control patients. Among diabetics, only EMPs in patients with hypertension was higher than in those without hypertension. Correlation analysis showed that systolic blood pressure and mean blood pressure were positively correlated with EMPs. Multivariant analysis demonstrated that EMP was an independent risk factor for the presence of hypertension in diabetics (odds ratio, 2.822; 95% confidence interval, 1.265-6.296; P=.011). Furthermore, baPWV in diabetics with hypertension (1910AE355 cm ⁄ s) was higher than that in control patients (1441AE198 cm ⁄ s) and diabetics without hypertension (1727AE2 cm ⁄ s). Multivariant analysis identified EMP as a potent contributor to the development of impaired artery elasticity in diabetics (odds ratio, 4.401; 95% confidence interval, 1.529-12.673; P=.006). Plasma EMP was associated with the presence of hypertension and impaired arterial stiffness in type 2 diabetes. J Clin Hypertens (Greenwich). 2012; 14:455-460. Ó2012 Wiley Periodicals, Inc.

Influence of a low-carbohydrate diet on endothelial microvesicles in overweight women

“…The timecourse for reductions in 2 EMV may therefore not always mirror reductions in body mass. Hypertension is 3 associated with elevated EMV (Chen et al, 2011), consistent with the mechanosensitive 4…”

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

“…These findings suggest that microparticles from EPCs and endothelial cells could be used as predictive biomarkers for ischemic stroke complication in diabetes, and targeting microparticles might offer new therapeutic avenues for diabetes and ischemic stroke. Levels of endothelial-derived, but not leukocyte-derived, microparticles are higher in hypertensive diabetic patients than in those without hypertension [23]. Endothelial-derived microparticles were shown to be an independent risk factor for the presence of hypertension in diabetic patients [23].…”

“…Levels of endothelial-derived, but not leukocyte-derived, microparticles are higher in hypertensive diabetic patients than in those without hypertension [23]. Endothelial-derived microparticles were shown to be an independent risk factor for the presence of hypertension in diabetic patients [23].…”

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

“…A recent study reported significantly higher levels of monomeric C-reactive protein (CRP)-positive MVs in patients with myocardial infarction compared with healthy controls [80] . In addition, elevated levels of circulating MVs have been associated with cardiovascular risk factors, including hyperten sion [15,32,52,100] , obesity [101,102] , cholesterol, and dyslipidemia [49,103] , as well as exposure to tobacco smoke [7] or air pollution [104,105] . An in vivo study also demonstrated that the levels of circulating endothelial-derived MVs and endothelial progenitor cell (EPC)-derived MVs are increased in diabetic animal models with ischemic stroke [106] .…”

“…Procoagulant platelet-derived MVs [47,48] , monocytederived MVs [14] , and endothelial-derived MVs [49] are significantly increased in patients with diabetes, even in wellcontrolled DM without complications [50] and newly diagnosed T2DM [51] . In addition, patients with diabetes accompanied by hyperten sion [15,16,32,[52][53][54][55][56][57] , hyperlipidemia [58][59][60] , stable coronary disease [61] , angina with [62] or without [17] symptomatic episodes, myocardial infarction [49,63] , diabetic retinopathy, and nephropathy [33,64] have significantly increased levels of procoagulant MVs compared with those without diabetic complications. Therefore, elevated levels of MVs may be associated with the increased risk of thrombo-embolic diabetic complications.…”