Plasma Endothelin-1 Elevation Associated With Alcohol-Induced Variant Angina

Kaku, Bunji; Mizuno, Sumio; Ohsato, Kazuo; Murakami, Tatsuaki; Moriuchi, Ikuo; Arai, Yoshiyuki; Nio, Yutaka; Ohe, Koutarou; Mabuchi, Tomohito; Takahashi, Yoshifumi; Ohnaka, Masateru

doi:10.1253/jcj.63.554

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…In the light of the above quoted experiments, and bearing in mind the results of our own research, two clinical cases of alcohol-induced angina pectoris presented by Kaku et al [14] seem especially interesting. Those authors reported the medical history of two male patients with chest pain appearing 5-7 h after alcohol consumption.…”

Section: Endothelinmentioning

confidence: 68%

Short-term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function: preliminary report of prospective randomised study

et al. 2013

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Section: Endothelinmentioning

confidence: 68%

Short-term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function: preliminary report of prospective randomised study

et al. 2013

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“…Previous studies have found that vascular endothelial growth factor (VEGF), leptin receptor (ob-R) and endothelin-1 (ET-1) interact with each other and participate in the regulation of vascular structure and function (1)(2)(3)(4). VEGF is an endothelial cell-specific mitogen and an effective angiogenic and permeability-enhancing factor (5).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

Yang

Wei

et al. 2013

International Journal of Molecular Medicine

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In the present study, we used chronic gavage administration of alcohol with gradual increases in alcohol concentration and volume to generate a rat model of chronic alcohol intoxication. We measured the changes in biological, behavioral, pathological and vascular injury-related molecular biological markers, and explored the effects of nimodipine intervention on alcohol intoxication. We found that chronic alcohol consumption induced a variety of behavioral abnormalities, accompanied by severe pathological changes in cerebral arterioles, prefrontal cortex and cerebellar tissue, as well as an upregulation of vascular endothelial growth factor (VEGF), leptin receptor (ob-R) and endothelin-1 (ET-1). Treatment with mimodipine for 15 days significantly improved behavioral abnormalities, alleviated the pathological changes in blood vessels and brain tissues, increased VEGF expression, decreased ob-R expression, reduced plasma ET-1 leakage and protected vascular and neuronal functions.

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“…Thus, drugs that can improve insulin resistance may be considered for treating medically refractory coronary spasm. Finally, the plasma concentration of endothelin-1 was elevated in two patients with CSA after they consumed alcohol (28). Although this study included only a small number of patients without any control arm, the results indicated a possible elevation of endothelin-1 endothelial dysfunction in patients with CSA, which is thought to play a role in the pathogenesis of coronary spasm.…”

Section: Endothelial Dysfunctionmentioning

confidence: 67%

“…The pathogenesis of coronary spasm may be multifactorial ( Fig. 1) (1,(6)(7)(8)(9)(10)(11)(12)(13)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), and drugs that are effective against these multiple factors may have potential for preventing medically refractory coronary spasm.…”

Section: Pharmacological Treatment For Medically Refractory Coronary mentioning

confidence: 99%

Treatment of Coronary Spastic Angina, Particularly Medically Refractory Coronary Spasm

Teragawa

Nishioka

Higashi

et al. 2008

Clinical medicine. Cardiology

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Abstract:Coronary spasm plays an important role in the pathogenesis of variant angina as well as ischaemic heart diseases. Treatment with vasodilators such as long-acting calcium channel blockers and long-acting nitrates is generally effective in preventing coronary spasm; however, in some patients coronary spasm is refractory to standard therapy. Because of endothelial dysfunction, hyper-reactivity of coronary smooth muscle cells and other triggering factors involved in the pathogenesis of coronary spasm, drugs capable of improving these conditions may be effective in preventing medically refractory coronary spasm. In addition, a spasm provocation test is frequently performed when diagnosing coronary spasms. Although intracoronary administration of nitroglycerin generally relieves the coronary spasm that results from this test, we have encountered patients who suffered haemodynamic instability during the test. Drugs that stabilize haemodynamics and dilate the coronary artery are effective in such situations. We review treatment options for coronary spasm that are refractory to the standard oral medications and to intracoronary infusion of nitroglycerin during the spasm provocation test.

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Plasma Endothelin-1 Elevation Associated With Alcohol-Induced Variant Angina

Cited by 11 publications

References 16 publications

Short-term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function: preliminary report of prospective randomised study

Short-term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function: preliminary report of prospective randomised study

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

Treatment of Coronary Spastic Angina, Particularly Medically Refractory Coronary Spasm

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