Plasma endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus

Žeravica, Radmila; Ilinčić, Branislava; Čabarkapa, Velibor; Sakac, Vladimir; Crnobrnja, Veljko; Stosić, Z

doi:10.2298/mpns1606140z

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Our findings support the hypothesis that common mechanisms may cause both retinal and renal vascular changes and that there is a correlation between the degree of diabetic retinopathy, 24-h albuminuria and kidney function [11,[15][16][17].…”

Section: Discussionsupporting

confidence: 86%

Correlation between eye and renal complications of diabetes

Anišić¹,

Davidović²

2018

Med pregl

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Introduction. Complications of diabetes can affect almost all tissues and organs, causing high morbidity, disability and mortality. The aim of this study was to examine eye and kidney disorders of patients with patients with diabetes, and assess the correlation between them. Material and Methods. This retrospective study included 45 patients suffering from type 2 diabetes for more than ten years. The patients were divided into three groups of 15 subjects each: patients without diabetic retinopathy, patients with non-proliferative retinopathy, and patients with proliferative diabetic retinopathy. Results. The average levels of fasting blood glucose and glycosylated hemoglobin were highest in patients with proliferative diabetic retinopathy (11.27 mmol/l and 8.48%, respectively). Of 30 patients with diabetic eye diseases, diabetic maculopathy was found in 60% of cases; of those, 20% had non-proliferative retinopathy and 40% had proliferative retinopathy. The mean values of best corrected visual acuity, in both eyes, were 0.45 in patients with proliferative diabetic retinopathy, while mean values of serum urea and creatinine, creatinine clearance, and 24-h albuminuria in this group were 7.37 mmol/l, 106.13 ?mol/l, 72.80 ml/min, and 346.31 mg/24h, respectively. Conclusion. Severe forms of diabetic retinopathy and nephropathy were found in patients with poor metabolic regulation. A correlation between diabetic eye and kidney diseases was established, and the level of visual damage correlated with the degree of renal function impairment.

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Section: Discussionsupporting

confidence: 86%

Correlation between eye and renal complications of diabetes

Anišić¹,

Davidović²

2018

Med pregl

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“…Endothelin 1 (ET1; also known as Edn1) is a potent vasoconstrictor that acts by binding to endothelin type A (ET A ) receptor and ET B receptor, which are expressed in a wide variety of cell types 154 . Increased urinary ET1 excretion has been observed in patients with diabetic kidney disease or FSGS 155 – 157 . Variation in the regulation or expression of ET1 or ET A receptor in humans is associated with vascular diseases including coronary artery disease, hypertension, renal artery stenosis, arterial dissection and migraine, but no genetic association with disease of the GFB has been demonstrated 158 , 159 .…”

Section: Targeting Actin and Myosinmentioning

confidence: 99%

The glomerular filtration barrier: a structural target for novel kidney therapies

Daehn

Duffield

2021

Nat Rev Drug Discov

129

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Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently treated with immunosuppressive agents, antihypertensives and diuretics with partial but limited success. Most kidney disease is characterized by breakdown of the glomerular filtration barrier (GFB). Specialized podocyte cells maintain the GFB, and structure–function experiments and studies of intercellular communication between the podocytes and other GFB cells, combined with advances from genetics and genomics, have laid the groundwork for a new generation of therapies that directly intervene at the GFB. These include inhibitors of apolipoprotein L1 (APOL1), short transient receptor potential channels (TRPCs), soluble fms-like tyrosine kinase 1 (sFLT1; also known as soluble vascular endothelial growth factor receptor 1), roundabout homologue 2 (ROBO2), endothelin receptor A, soluble urokinase plasminogen activator surface receptor (suPAR) and substrate intermediates for coenzyme Q10 (CoQ 10 ). These molecular targets converge on two key components of GFB biology: mitochondrial function and the actin–myosin contractile machinery. This Review discusses therapies and developments focused on maintaining GFB integrity, and the emerging questions in this evolving field.

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“…The main members of the ET family include ET‐1–3. Among them, ET‐1 is involved in kidney disease (DKD (Zeravica et al 2016), focal segmental glomerulosclerosis (Daehn et al 2014), etc.). It has two receptor (ETR) subtypes, endothelin receptor‐A (ET‐A) and endothelin receptor‐B (ET‐B).…”

Section: Cellular Crosstalk Of Podocytesmentioning

confidence: 99%

Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease

Jiang

Luo

Bai

et al. 2022

J. Cell Commun. Signal.

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Diabetic kidney disease (DKD) is a serious microvascular complication of diabetes and is the leading cause of end-stage renal disease (ESRD). Persistent proteinuria is an important feature of DKD, which is caused by the destruction of the glomerular filtration barrier (GFB). Glomerular endothelial cells (GECs) and podocytes are important components of the GFB, and their damage can be observed in the early stages of DKD. Recently, studies have found that crosstalk between cells directly affects DKD progression, which has prospective research significance. However, the pathways involved are complex and largely unexplored. Here, we review the literature on cellular crosstalk of GECs and podocytes in the context of DKD, and highlight specific gaps in the field to propose future research directions. Elucidating the intricates of such complex processes will help to further understand the pathogenesis of DKD and develop better prevention and treatment options.

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Plasma endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus

Cited by 5 publications

References 21 publications

Correlation between eye and renal complications of diabetes

Correlation between eye and renal complications of diabetes

The glomerular filtration barrier: a structural target for novel kidney therapies

Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease

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