Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis

Morelli, Sergio; Ferri, Claudio; Polettini, E; Bellini, Cesare; Gualdi, Gian Franco; Pittoni, V.; Valesini, Guido; Santucci, A.

doi:10.1016/s0002-9343(99)80157-0

Cited by 99 publications

(42 citation statements)

References 19 publications

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“…An even simpler scoring method was published by Morelli et al [15]. They divided the lungs into three zones: apices to main carina, main carina to inferior pulmonary venous confluence, and pulmonary veins to diaphragms, representing upper, middle and lower zones respectively.…”

Section: Description Of Scoring Systems Comparative Scoringmentioning

confidence: 99%

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Assayag¹,

Kaduri²,

Hudson³

2012

Rheumatology

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Interstitial lung disease commonly develops in patients with Systemic sclerosis (SSc). High resolution computed tomography (HRCT) has become the gold standard for detection and evaluation of lung involvement in SSc. Several HRCT scoring methods have been described and used to characterize and quantify the disease. This article reviews the different scoring systems and how they have been validated clinically and applied to prognosticate patients, assess disease progression and evaluate response to treatment.

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Section: Description Of Scoring Systems Comparative Scoringmentioning

confidence: 99%

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Assayag¹,

Kaduri²,

Hudson³

2012

Rheumatology

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“…ET-1 wird aus prepro-ET und pro-ET-1 durch das "endothelin-converting enzyme" (ECE) erzeugt. Patienten mit pulmonal-arterieller Hypertonie haben erhöhte Plasmaund Gewebespiegel von ET-1 [19,20,21].…”

Section: Endothelinrezeptorantagonisten (Era)unclassified

Aktuelle Therapie der pulmonal-arteriellen Hypertonie

et al. 2010

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“…Scleroderma fibroblasts release ET-1 [45], and elevated ET-1 levels are found in patients with SSc compared with healthy control subjects [46]. Patients with diffuse SSc have higher levels of ET-1 than patients with limited SSc [47,48].…”

Section: Treatmentmentioning

confidence: 99%

Scleroderma renal crisis: New insights and developments

Rhew¹,

Barr

2004

Curr Rheumatol Rep

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Scleroderma renal crisis (SRC) was once a uniformly fatal complication of systemic sclerosis (SSc). With the introduction of angiotensin-converting enzyme inhibitors as treatment, outcomes have improved significantly, though 39% to 50% of SSc patients who develop SRC continue to have poor outcomes, including permanent dialysis and death. Early recognition and treatment with angiotensin-converting enzyme inhibitors are important in the effective management of SRC, though given the continuing morbidity and mortality caused by SRC, they are clearly not sufficient. Newer therapies based on the pathophysiologic mechanisms underlying the development and perpetuation of SRC are needed. This article reviews the epidemiology, pathogenesis, risk factors, clinical features, and treatment of SRC, with an emphasis on recent insights and developments.

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Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis

Cited by 99 publications

References 19 publications

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Aktuelle Therapie der pulmonal-arteriellen Hypertonie

Scleroderma renal crisis: New insights and developments

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