Plasma enzymes and metabolites as potential prognostic indices of ovine pregnancy toxaemia—A preliminary study

Sargison, Neil; Scott, Phil; Penny, Colin; Pirie, R. S.; Kelly, J. M.

doi:10.1016/s0007-1935(05)80007-7

Cited by 37 publications

(33 citation statements)

References 20 publications

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“…Seric activity of this enzyme did not significantly differ between groups, ranging from 38 to 197, and from 39 to 195UI/L from days 130 to 140 in Groups A and B, respectively. Alkaline phosphatase seem not to be useful for indirect assessment of liver steatosis severity in ewes undergoing pregnancy toxemia, contrary to what was suggested by Sargison et al (1994).…”

Section: Resultscontrasting

confidence: 73%

“…Ovine pregnancy toxemia is a common metabolic disorder of undernourished ewes due Recebido em 28 de outubro de 2008 Aceito em 18 de março de 2009 E-mail: luiscalper@gmail.com to increased fetal energy requirements in late pregnancy (Sargison et al, 1994). As fetal demand of glucose exceeds dietary energy intake, increased lipolysis lead to an augmented synthesis of ketone bodies (specially hydroxybutyrate) to maintain metabolic homeostasis (Pethick and Lindsay, 1982;Sargison et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…As fetal demand of glucose exceeds dietary energy intake, increased lipolysis lead to an augmented synthesis of ketone bodies (specially hydroxybutyrate) to maintain metabolic homeostasis (Pethick and Lindsay, 1982;Sargison et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…Available information about pregnancy toxemia focus mainly on pathogenic mechanisms and clinical features (Reid, 1968;Wastney et al, 1983;Marteniuk, 1988;Andrews, 1997), early diagnosis (Sargison et al, 1994;Scott et al, 1995), and therapeutic options (Wierda et al, 1985;Buswell et al, 1986;Marteniuk and Herdt, 1988;El-Hamamsy et al, 1990). …”

Section: Introductionmentioning

confidence: 99%

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Histological changes of the liver and metabolic correlates in ewes with pregnancy toxemia

Cal

Borteiro

Benech

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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The histological changes of the liver in ewes with pregnancy toxemia were characterized. Ten ewes were fed on grass ad libitum, and another ten were starved from day 130 of pregnancy for up to four days. Liver puncture biopsies were performed at days 70, 100, 130, and 140 of pregnancy, and at day 45 in postpartum. Seric hydroxybutyrate (HB), non-esterified fatty acids (NEFA), aspartate aminotransferase, and alkaline phosphatase were dosed. Histological preparations revealed similar incidence and intensity of mild liver steatosis in both groups at day 130. Starved ewes become toxemic (as indicated by HB), and at day 140 exhibited more severe injury in a higher proportion (9/9 vs. 4/10; P<0.01). Almost all of them (7/9) had large amounts of small lipid droplets in almost every hepatocyte over the whole liver acinus, and higher NEFA values. At day 45 in postpartum, both groups had mild steatotic changes as initially. A positive correlation between severity of liver damage seric and only aspartate aminotransferase was observed at day 140 in starved animals (P<0.05). This enzyme could be used to assess liver damage, but not alkaline phosphatase. All samples with degeneration corresponded to the microvesicular type. A short starvation period during late pregnancy in ewes produced reversible liver degeneration. (9/9 vs. 4/10; P<0,01)

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Section: Resultscontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological changes of the liver and metabolic correlates in ewes with pregnancy toxemia

Cal

Borteiro

Benech

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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“…As ovelhas acometidas, em geral, apresentam alterações como hipercetonemia, cetonúria, hipoglicemia, níveis elevados dos ácidos graxos não esteriϐicados (AGNE) e cortisol, além do comprometimento da função hepática e renal (Ferris et al 1969, Ortolani & Benesi 1989, Bruere & West 1993, Sargison et al 1994, Andrews et al 1996.…”

Section: Introductionunclassified

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Santos¹,

Mendonça

Filho³

et al. 2011

Pesq. Vet. Bras.

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Toxemia da prenhez é considerada um transtorno metabólico de grande impacto econômico na produção de ovinos, porém as particularidades de repercussão sistêmicas deste distúrbio ainda são pouco esclarecedoras. O presente estudo teve por objetivo avaliar o perfil bioquímico e hormonal de 77 ovelhas com diagnóstico clínico de toxemia da penhez e comparar os achados laboratoriais de acordo com a resolução clínica dos animais, alta hospitalar (G1) e aqueles que morreram (G2). A manifestação clinica da doença foi observada no período do pré-parto em 100% dos animais, destes 66,2 % (n=51) receberam alta clínica e 33,8% (n=26) morreram. Dos casos de toxemia da prenhez estudados havia gestação múltipla em 55,8%. Dentre os parâmetros estudados, cortisol, uréia, AST e CK estavam mais elevados no G2 em relação ao G1 com diferenças significativas (P<0,05). Foi encontrado aumento nas concentrações de glicose plasmática, frutosamina, albumina, creatinina, ß-hidroxubutirato, ácido graxo não esterificado e L-lactato, porém não houve diferenças entre os grupos (P>0,05). Não ocorreram alterações nas taxas de colesterol e triglicerídios. Houve redução nos índices da insulina, não havendo diferenças entre G1 e G2 (P>0,05). Todas as ovelhas apresentaram cetonúria e acidúria.

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Advances in managing pregnancy toxaemia in sheep

Crilly¹,

Phythian²,

Evans³

2021

In Practice

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Background: Ovine pregnancy toxaemia (OPT) is a metabolic disorder of ewes in late pregnancy. Cases are typically seen in ewes carrying multiple fetuses, hence the alternative name of ‘twin lamb disease’. The disease has been well known for many years. Despite this, the toll inflicted by the disease remains considerable, due both to the poor prognosis of clinically affected animals, even with appropriate treatment, and the impact of the provoking factors of under‐nutrition and concomitant disease on ewe morbidity, lamb survival and flock productivity. Cases of OPT are an indication of shortcomings in the management of late‐pregnancy ewes. Aim of the article: This article provides an update on the aetiopathogenesis, diagnosis, treatment and prevention of OPT, drawing on recently published studies.

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Plasma enzymes and metabolites as potential prognostic indices of ovine pregnancy toxaemia—A preliminary study

Cited by 37 publications

References 20 publications

Histological changes of the liver and metabolic correlates in ewes with pregnancy toxemia

Histological changes of the liver and metabolic correlates in ewes with pregnancy toxemia

Indicadores bioquímicos e hormonais de casos naturais de toxemia da prenhez em ovelhas

Advances in managing pregnancy toxaemia in sheep

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